A type i interferon signature characterizes chronic antibody-mediated rejection in kidney transplantation

Journal of Pathology

Volumn 237, Issue 1, 2015, Pages 72-84

  Rascio, Federica ^a   Pontrelli, Paola ^b   Accetturo, Matteo ^b   Oranger, Annarita ^b   Gigante, Margherita ^b   Castellano, Giuseppe ^b   Gigante, Maddalena ^a   Zito, Anna ^b   Zaza, Gianluigi ^c   Lupo, Antonio ^c   Ranieri, Elena ^a   Stallone, Giovanni ^a   Gesualdo, Loreto ^b   Grandaliano, Giuseppe ^a  

^a UNIVERSITY OF FOGGIA   (Italy)

^b UNIVERSITY OF BARI   (Italy)

^c UNIVERSITY OF VERONA   (Italy)

Author keywords

chronic antibody mediated rejection; immunology; kidney transplantation; messenger RNA and microRNA profiling; peripheral blood mononuclear cells; T lymphocytes; type I interferon

Indexed keywords

ALPHA INTERFERON; BETA INTERFERON; CXCL9 CHEMOKINE; EXCITATORY AMINO ACID TRANSPORTER 5; GAMMA INTERFERON; INTERFERON; INTERFERON INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 1; INTERFERON INDUCED PROTEIN WITH TETRATRICOPEPTIDE REPEATS 3; LET 7A; MESSENGER RNA; MICRORNA; MICRORNA 148B 3P; MICRORNA 16 5P; MICRORNA 29B; MICRORNA 29B 3P; MICRORNA 769 5P; MYXOVIRUS RESISTANCE PROTEIN A; STAT1 PROTEIN; STAT2 PROTEIN; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; TRANSCRIPTOME;

ADULT; ANTIBODY MEDIATED REJECTION; ARTICLE; CD4+ T LYMPHOCYTE; CLINICAL ARTICLE; COMPUTER MODEL; CONTROLLED STUDY; DENDRITIC CELL; DOWN REGULATION; FEMALE; GENE EXPRESSION; GENE EXPRESSION PROFILING; GENETIC ASSOCIATION; GRAFT RECIPIENT; HUMAN; HUMAN CELL; KIDNEY BIOPSY; KIDNEY FIBROSIS; KIDNEY GRAFT REJECTION; KIDNEY TRANSPLANTATION; KIDNEY TUBULE DISORDER; MALE; MICROARRAY ANALYSIS; MIDDLE AGED; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE SUBPOPULATION; TRANSCRIPTOMICS; UPREGULATION; ADVERSE EFFECTS; AGED; BIOPSY; BLOOD; CASE CONTROL STUDY; CHRONIC DISEASE; DNA MICROARRAY; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORK; GENETIC TRANSCRIPTION; GENETICS; GRAFT REJECTION; IMMUNOLOGY; KIDNEY; METABOLISM; MONONUCLEAR CELL; PATHOLOGY; PROCEDURES; SURGERY; TREATMENT OUTCOME;

ADULT; AGED; BIOLOGICAL MARKERS; BIOPSY; CASE-CONTROL STUDIES; CD4-POSITIVE T-LYMPHOCYTES; CHRONIC DISEASE; FEMALE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENE REGULATORY NETWORKS; GENETIC ASSOCIATION STUDIES; GRAFT REJECTION; HUMANS; INTERFERON TYPE I; KIDNEY; KIDNEY TRANSPLANTATION; LEUKOCYTES, MONONUCLEAR; MALE; MICRORNAS; MIDDLE AGED; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; RNA, MESSENGER; SIGNAL TRANSDUCTION; TRANSCRIPTION, GENETIC; TRANSCRIPTOME; TREATMENT OUTCOME;

EID: 84938769719     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.4553     Document Type: Article

References (34)

1. Pascual M, Theruvath T, Kawai T, et al., Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 2002; 346: 580-590.
2. Einecke G, Sis B, Reeve J, et al., Antibody-mediated microcirculation injury is the major cause of late kidney transplant failure. Am J Transplant 2009; 9: 2520-2531.
3. Sellarés J, de Freitas DG, Mengel M, et al., Understanding the causes of kidney transplant failure: the dominant role of antibody-mediated rejection and non-adherence. Am J Transplant 2012; 12: 388-399.
4. Smith RN, Colvin RB,. Chronic alloantibody mediated rejection. Semin Immunol 2012; 24: 115-121.
5. Kohei N, Hirai T, Omoto K, et al., Chronic antibody-mediated rejection is reduced by targeting B-cell immunity during an introductory period. Am J Transplant 2012; 12: 469-476.
6. Singh N, Pirsch J, Samaniego M,. Antibody-mediated rejection: treatment alternatives and outcomes. Transplant Rev 2009; 23: 34-46.
7. Sarwal M, Chua MS, Kambham N, et al., Molecular heterogeneity in acute renal allograft rejection identified by DNA microarray profiling. N Engl J Med 2003; 349: 125-138.
8. Flechner SM, Kurian SM, Head SR, et al., Kidney transplant rejection and tissue injury by gene profiling of biopsies and peripheral blood lymphocytes. Am J Transplant 2004; 4: 1475-1489.
9. Sagoo P, Perucha E, Sawitzki B, et al., Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest 2010; 120: 1848-1861.
10. Newell KA, Asare A, Kirk AD, et al., Identification of a B cell signature associated with renal transplant tolerance in humans. J Clin Invest 2010; 120: 1836-1847.
11. Scherer A, Krause A, Walker JR, et al., Early prognosis of the development of renal chronic allograft rejection by gene expression profiling of human protocol biopsies. Transplantation 2003; 75: 1323-1330.
12. Horwitz PA, Tsai EJ, Putt ME, et al., Detection of cardiac allograft rejection and response to immunosuppressive therapy with peripheral blood gene expression. Circulation 2004; 110: 3815-3821.
13. Tili E, Michaille JJ, Gandhi V, et al., miRNAs and their potential for use against cancer and other diseases. Future Oncol 2007; 5: 521-537.
14. Lewis BP, Shih IH, Jones-Rhoades MW, et al., Prediction of mammalian microRNA targets. Cell 2003; 115: 787-798.
15. Mengel M, Sis B, Haas M, et al., Banff 2011 Meeting report: new concepts in antibody-mediated rejection. Am J Transplant 2012; 12: 563-570.
16. Dell'Oglio MP, Zaza G, Rossini M, et al., The anti-fibrotic effect of mycophenolic acid-induced neutralendopeptidase. J Am Soc Nephrol 2010; 21: 2157-2168.
17. Gigante M, Blasi A, Loverre A, et al., Dysfunctional DC subsets in RCC patients: ex vivo correction to yield an effective anti-cancer vaccine. Mol Immunol 2009; 46: 893-901.
18. Fiore N, Castellano G, Blasi A, et al., Immature myeloid and plasmacytoid dendritic cells infiltrate renal tubulointerstitium in patients with lupus nephritis. Mol Immunol 2008, 45: 259-265.
19. Kirou KA, Lee C, George S, et al., Coordinate overexpression of interferon-alpha-induced genes in systemic lupus erythematosus. Arthritis Rheum 2004; 50: 3958-3967.
20. Naesens M, Khatri P, Li Li, et al., Progressive histological damage in renal allografts is associated with expression of innate and adaptive immunity genes. Kidney Int 2011; 80: 1364-1376.
21. Sis B, Jhangri GS, Bunnag S, et al., Endothelial gene expression in kidney transplants with alloantibody indicates antibody mediated damage despite lack of C4d staining. Am J Transplant 2009; 9: 2312-2323.
22. Famulski KS, Einecke G, Reeve J, et al., Changes in the transcriptome in allograft rejection: IFN-gamma induced transcripts in mouse kidney allografts. Am J Transplant 2006; 6: 1342-1354.
23. Reeve J, Einecke G, Mengel M, et al., Diagnosing rejection in renal transplants: a comparison of molecular- and histopathology-based approaches. Am J Transplant 2009; 9: 1802-1810.
24. Harris A, Krams SM, Martinez OM,. MicroRNAs as immune regulators: implications for transplantation. Am J Transplant 2010; 10: 713-719.
25. Danger R, Paul C, Giral M, et al., Expression of miR-142-5p in peripheral blood mononuclear cells from renal transplant patients with chronic antibody-mediated rejection. PLoS One 2013; 8: e60702.
26. Dauer M, Schad K, Junkmann J, et al., IFN-alpha promotes definitive maturation of dendritic cells generated by short-term culture of monocytes with GM-CSF and IL-4. J Leukoc Biol 2006; 80: 278-286.
27. Carbonneil C, Saidi H, Donkova-Petrini V, et al., Dendritic cells generated in the presence of interferon-alpha stimulate allogeneic CD4+ T-cell proliferation: modulation by autocrine IL-10, enhanced T-cell apoptosis and T regulatory type 1 cells. Int Immunol 2004; 16: 1037-1052.
28. Gujer C, Sandgren KJ, Douagi I, et al., IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naïve B cell differentiation. J Leukoc Biol 2011; 89: 811-821.
29. Baechler EC, Batliwalla FM, Karypis G, et al., Interferon-inducible gene expression signature in peripheral blood cells of patients with severe lupus. Proc Natl Acad Sci U S A 2003; 100: 2610-2615.
30. Thaunat O, Graff-Dubois S, Fabien N, et al., A stepwise breakdown of B-cell tolerance occurs within renal allografts during chronic rejection. Kidney Int 2012; 81: 207-219.
31. Hagberg N, Berggren O, Leonard D, et al., IFN-alpha production by plasmacytoid dendritic cells stimulated with RNA-containing immune complexes is promoted by NK cells via MIP-1b and LFA-1. J Immunol 2011; 186: 5085-5094.
32. Hidalgo LG, Sis B, Sellares J, et al., NK cell transcripts and NK cells in kidney biopsies from patients with donor-specific antibodies: evidence for NK cell involvement in antibody-mediated rejection. Am J Transplant 2010; 10: 1812-1822.
33. Niewold TB,. Interferon alpha as a primary pathogenic factor in human lupus. J Interferon Cytokine Res 2011; 31: 887-892.
34. Haas M, Sis B, Racusen LC, et al., Banff 2013 meeting report: inclusion of C4d-negative antibody-mediated rejection and antibody-associated arterial lesions. Am J Transplant 2014; 14: 272-283.