In vivo Antimalarial Activity of α-Mangostin and the New Xanthone δ-Mangostin

Phytotherapy Research

Volumn 29, Issue 8, 2015, Pages 1195-1201

  Upegui, Yulieth ^a   Robledo, Sara M ^a,b   Gil Romero, Juan Fernando ^a   Quiñones, Winston ^a   Archbold, Rosendo ^a   Torres, Fernando ^a   Escobar, Gustavo ^a   Nariño, Bibiana ^a   Echeverri, Fernando ^a  

^a UNIVERSIDAD DE ANTIOQUIA   (Colombia)

^b CIDEPRO Center for Development of Products Against Tropical Diseases   (Colombia)

Author keywords

antimalarial activity; Garcinia mangostana; Plasmodium berghei; Plasmodium falciparum; xanthones

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA MANGOSTIN; CHLOROQUINE; CREATININE; DELTA MANGOSTIN; UNCLASSIFIED DRUG; UREA; XANTHONE DERIVATIVE; ANTIMALARIAL AGENT; MANGOSTIN;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIMALARIAL ACTIVITY; ANTIMALARIAL DRUG RESISTANCE; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; CYTOTOXICITY; DRUG BIOAVAILABILITY; DRUG EFFICACY; DRUG STRUCTURE; GARCINIA MANGOSTANA; HEMOLYSIS; HETERONUCLEAR SINGLE QUANTUM COHERENCE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; IN VIVO STUDY; MASS SPECTROMETRY; MOUSE; NONHUMAN; PARASITEMIA; PLASMODIUM BERGHEI INFECTION; PLASMODIUM FALCIPARUM 3D7; SEED HUSK; UREA NITROGEN BLOOD LEVEL; ANIMAL; BAGG ALBINO MOUSE; CHEMISTRY; DISEASE MODEL; DRUG EFFECTS; ERYTHROCYTE; INTRAPERITONEAL DRUG ADMINISTRATION; MALARIA; PLASMODIUM FALCIPARUM; U937 CELL LINE;

GARCINIA MANGOSTANA; MURINAE; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM;

ANIMALS; ANTIMALARIALS; DISEASE MODELS, ANIMAL; ERYTHROCYTES; GARCINIA MANGOSTANA; HEMOLYSIS; HUMANS; INJECTIONS, INTRAPERITONEAL; MALARIA; MICE; MICE, INBRED BALB C; PARASITEMIA; PLASMODIUM FALCIPARUM; U937 CELLS; XANTHONES;

EID: 84938750811     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5362     Document Type: Article

References (31)

1. Al-Massarani SM, El Gamal AA, Al-Musayeib NM, et al,. 2013. Phytochemical, antimicrobial and antiprotozoal evaluation of Garcinia mangostana pericarp and α-mangostin, its major xanthone derivative. Molecules 18: 10,599-10,608.
2. Balunas MJ, Su B, Brueggemeier RW, et al,. 2008. Xanthones from the botanical dietary supplement mangosteen (Garcinia mangostana) with aromatase inhibitory activity. J Nat Prod 71: 1161-1166.
3. Barea C, Pabõn A, Pérez S,. 2013. New amide derivatives of quinoxaline 1,4-di-N-oxide with leishmanicidal and antiplasmodial activities. Molecules 18: 4718-4727.
4. Conceição K, Konno K, Richardson M, et al,. 2006. Orpotrin: a novel vasoconstrictor peptide from the venom of the Brazilian Stingray Potamotrygon gr. orbignyi. Peptides 27: 3092-3099.
5. Enserink M,. 2007. Malaria treatment: ACT two. Science 318: 560-563.
6. Finney JD,. 1978. Statistical Method in Biological Assay, 3rd edn. Academic Press: London; 508.
7. Fotie J, Nkengfack AE, Rukunga G,. 2003. In-vivo antimalarial activity of some oxygenated xanthones. Ann Trop Med Parasitol 97: 683-688.
8. Gutiérrez F, Failla ML,. 2013. Biological activities and bioavailability of mangosteen xanthones: a critical review of the current evidence. Nutrients 5: 3163-3183.
9. Han AR, Kim JA, Lantvit DD, et al,. 2009. Cytotoxic xanthone constituents of the stem bark of Garcinia mangostana (mangosteen). J Nat Prod 72: 2028-2031.
10. Hay AE, Hélesbeux JJ, Duval O, et al,. 2004. Antimalarial xanthones from Calophyllum caledonicum and Garcinia vieillardii. Life Sci 75: 3077-3085.
11. Insuasty B, Ramírez J, Becerra D, et al,. 2015. An efficient synthesis of new caffeine-based chalcones, pyrazolines and pyrazolo[3,4-b][1,4]diazepines as potential antimalarial, antitrypanosomal and antileishmanial agents. Eur J Med Chem 93: 401-413.
12. Li L, Brunner I, Han AR, et al,. 2011. Pharmacokinetics of α-mangostin in rats after intravenous and oral application. Mol Nutr Food Res 55: S67-S74.
13. Limei Y, Mouming Z, Bao Y, et al,. 2007. Phenolics from hull of Garcinia mangostana fruit and their antioxidant activities. Food Chem 104: 176-181.
14. Marques ES, Silva S, Niero R, et al,. 2012. Genotoxicity assessment of Garcinia achachairu Rusby (Clusiaceae) extract in mammalian cells in vivo. J Ethnopharmacol 142: 362-366.
15. Michel T, Destandau E, Fougére L, et al,. 2012. New "hyphenated" CPC-HPLC-DAD-MS strategy for simultaneous isolation, analysis and identification of phytochemicals: application to xanthones from Garcinia mangostana. Anal Bioanal Chem 404: 2963-2972.
16. Molinar E, Gonzalez J, Ortega E, et al,. 2006. Antiprotozoal activity against Plasmodium falciparum and Trypanosoma cruzi of xanthones isolated from Chrysochlamys tenuis. Pharm Biol 44: 550-553.
17. Murray CJ, Rosenfeld LC, Lim SS, et al,. 2012. Global malaria mortality between 1980 and 2010: a systematic analysis. Lancet 379: 413-431.
18. Obolskiy D, Pischel I, Siriwatanametanon N, et al,. 2009. Garcinia mangostana L. A phytochemical and pharmacological review. Phytother Res 23: 1047-1065.
19. Ovenden SP, Cobbe M, Kissell R, et al,. 2011. Phenolic glycosides with antimalarial activity from Grevillea "Poorinda Queen". J Nat Prod 74: 74-78.
20. Pedraza J, Cárdenas N, Orozco M, et al,. 2008. Medicinal properties of mangosteen (Garcinia mangostana). Food Chem Toxicol 46: 3227-3239.
21. Riscoe M, Kelly JX, Winter R,. 2005. Xanthones as antimalarial agents: discovery, mode of action, and optimization. Curr Med Chem 12: 2539-2549.
22. Robledo S, Osorio E, Muñoz D, et al,. 2005. In vitro and in vivo cytotoxicities and antileishmanial activities of thymol and hemisynthetic derivates. Antimicrob Agents Chemother 49: 1652-1655.
23. Ruiz L, Ruiz L, Maco M,. 2011. Plants used by native Amazonian groups from the Nanay River (Peru) for the treatment of malaria. J Ethnopharmacol 133: 917-921.
24. Ryley JF, Peters W,. 1970. The antimalarial activity of some quinolone esters. Ann Trop Med Parasitol 64: 209-222.
25. Shan T, Ma Q, Guo K, et al,. 2011. Xanthones from mangosteen extracts as natural chemopreventive agents: potential anticancer drugs. Curr Mol Med 11: 666-677.
26. Taylor VM, Cedeño DL, Muñoz DL, et al,. 2011. In vitro and in vivo studies of the utility of dimethyl and diethyl carbaporphyrin ketals in treatment of cutaneous leishmaniasis. Antimicrob Agents Chemother 55: 4755-4764.
27. Toshihiro M, Kazuyuki T,. 2012. Evolution of Plasmodium falciparum drug resistance: implications for the development and containment of artemisinin resistance. Jpn J Infect Dis 65: 465-475.
28. Trager W, Jensen JB,. 1976. Human malaria parasites in continuous culture. Science 193: 673-675.
29. World Health Organization. World malaria report 2013a. http://www.who.int/malaria/publications/world-malaria-report-2013/en/
30. World Health Organization. World health statistics 2013b. http://www.who.int/gho/publications/world-health-statistics/2013/en/
31. Zarena AS, Udaya SK,. 2011. Xanthones enriched extracts from mangosteen pericarp obtained by supercritical carbon dioxide process. Sep Purif Technol 80: 172-178.