Transient Expression of Virally Delivered Meganuclease In Planta Generates Inherited Genomic Deletions

Molecular Plant

Volumn 8, Issue 8, 2015, Pages 1292-1294

  Honig, Arik ^a   Marton, Ira ^a   Rosenthal, Michal ^a   Smith, J Jeff ^b   Nicholson, Michael G ^b   Jantz, Derek ^b   Zuker, Amir ^a   Vainstein, Alexander ^c  

^a Danziger Innovations Ltd   (Israel)

^b PRECISION BIOSCIENCES   (United States)

^c HEBREW UNIVERSITY OF JERUSALEM   (Israel)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOL DEHYDROGENASE; DEOXYRIBONUCLEASE; DIHYDROFLAVANOL 4-REDUCTASE;

GENE DELETION; GENE EXPRESSION; GENETICS; INHERITANCE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PLANT GENOME; PLANT VIRUS; TOBACCO; VIROLOGY;

ALCOHOL OXIDOREDUCTASES; BASE SEQUENCE; DEOXYRIBONUCLEASES; GENE EXPRESSION; GENOME, PLANT; INHERITANCE PATTERNS; MOLECULAR SEQUENCE DATA; PLANT VIRUSES; SEQUENCE DELETION; TOBACCO;

EID: 84938749320     PISSN: 16742052     EISSN: 17529867     Source Type: Journal    
DOI: 10.1016/j.molp.2015.04.001     Document Type: Letter

References (10)

1. N. Baltes, and D. Voytas Enabling plant synthetic biology through genome engineering Trends Biotechnol. 33 2014 120 131
2. N. Baltes, J. Gil-Humanes, T. Cermak, P. Atkins, and D. Voytas DNA replicons for plant genome engineering Plant Cell 26 2014 151 163
3. S. Kim, M. Binzel, S. Park, K. Yoo, and L. Pike Inactivation of DFR (dihydroflavonol 4-reductase) gene transcription results in blockage of anthocyanin production in yellow onions (Allium cepa) Mol. Breed. 14 2004 253 263
4. A. Knoll, F. Fauser, and H. Puchta DNA recombination in somatic plant cells: mechanisms and evolutionary consequences Chromosome Res. 22 2014 191 201
5. I. Marton, A. Zuker, E. Shklarman, V. Zeevi, A. Tovkach, S. Roffe, M. Ovadis, T. Tzfira, and A. Vainstein Nontransgenic genome modification in plant cells Plant Physiol. 154 2010 1079 1087
6. I. Marton, A. Honig, A. Omid, N. de Costa, E. Marhevka, B. Cohen, A. Zuker, and A. Vainstein From Agrobacterium to viral vectors: genome modification of plant cells by rare cutting restriction enzymes Int. J. Dev. Biol. 57 2013 639 650
7. S. Tsuda, Y. Fukui, N. Nakamura, Y. Katsumoto, K. Yonekura-Sakakibara, M. Fukuchi-Mizutani, K. Ohira, Y. Ueyama, H. Ohkawa, T.A. Holton, and et al. Flower color modification of Petunia hybrida commercial varieties by metabolic engineering Plant Biotechnol. 21 2004 377 386
8. D. Voytas, and S. Merchant Plant genome engineering with sequence-specific nucleases Annu. Rev. Plant Biol. 64 2013 327 350
9. D. Voytas, and C. Gao Precision genome engineering and agriculture: opportunities and regulatory challenges PLoS Biol. 12 2014 e1001877
10. B. Winkel-Shirley Flavonoid biosynthesis. A colorful model for genetics, biochemistry, cell biology, and biotechnology Plant Physiol. 126 2001 485 493