Targeting Plant Ethylene Responses by Controlling Essential Protein-Protein Interactions in the Ethylene Pathway

Molecular Plant

Volumn 8, Issue 8, 2015, Pages 1165-1174

  Bisson, Melanie M A ^a   Groth, Georg ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

ethylene responses; fruit ripening; inhibitor; peptide; protein protein interactions

Indexed keywords

ARABIDOPSIS PROTEIN; CELL SURFACE RECEPTOR; EIN2 PROTEIN, ARABIDOPSIS; ETHYLENE; ETHYLENE DERIVATIVE; ETR1 PROTEIN, ARABIDOPSIS; NUCLEAR LOCALIZATION SIGNAL; PEPTIDE; PROTEIN BINDING;

AMINO ACID SEQUENCE; ARABIDOPSIS; BIOASSAY; CHEMISTRY; FRUIT; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR GENETICS; NUCLEAR LOCALIZATION SIGNAL; PROTEIN ANALYSIS; PROTEIN MOTIF; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION; TOMATO;

AMINO ACID MOTIFS; AMINO ACID SEQUENCE; ARABIDOPSIS; ARABIDOPSIS PROTEINS; BIOLOGICAL ASSAY; ETHYLENES; FRUIT; LYCOPERSICON ESCULENTUM; MOLECULAR SEQUENCE DATA; NUCLEAR LOCALIZATION SIGNALS; PEPTIDES; PROTEIN BINDING; PROTEIN INTERACTION MAPPING; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84938749068     PISSN: 16742052     EISSN: 17529867     Source Type: Journal    
DOI: 10.1016/j.molp.2015.03.014     Document Type: Article

References (29)

1. J.M. Alonso, T. Hirayama, G. Roman, S. Nourizadeh, and J.R. Ecker EIN2, a bifunctional transducer of ethylene and stress responses in Arabidopsis Science 284 1999 2148 2152
2. M.R. Arkin, and J.A. Wells Small-molecule inhibitors of protein-protein interactions: progressing towards the dream Nat. Rev. Drug Discov. 3 2004 301 317
3. M.M.A. Bisson, and G. Groth New insight in ethylene signaling: autokinase activity of ETR1 modulates the interaction of receptors and EIN2 Mol. Plant 3 2010 882 889
4. M.M.A. Bisson, and G. Groth New paradigm in ethylene signaling: EIN2, the central regulator of the signaling pathway, interacts directly with the upstream receptors Plant Signal. Behav. 6 2011 164 166
5. M.M.A. Bisson, A. Bleckmann, S. Allekotte, and G. Groth EIN2, the central regulator of ethylene signalling, is localized at the ER membrane where it interacts with the ethylene receptor ETR1 Biochem. J. 424 2009 1 6
6. A. Bleckmann, S. Weidtkamp-Peters, C.A. Seidel, and R. Simon Stem cell signaling in Arabidopsis requires CRN to localize CLV2 to the plasma membrane Plant Physiol. 152 2010 166 176
7. A.B. Bleecker, M.A. Estelle, C. Somerville, and H. Kende Insensitivity to ethylene conferred by a dominant mutation in Arabidopsis thaliana Science 241 1988 1086 1089
8. A.C. Braisted, J.D. Oslob, W.L. Delano, J. Hyde, R.S. McDowell, N. Waal, C. Yu, M.R. Arkin, and B.C. Raimundo Discovery of a potent small molecule IL-2 inhibitor through fragment assembly J. Am. Chem. Soc. 125 2003 3714 3715
9. C. Chang, S.F. Kwok, A.B. Bleecker, and E.M. Meyerowitz Arabidopsis ethylene-response gene ETR1: similarity of product to two-component regulators Science 262 1993 539 544
10. B.C. Cunningham, and J.A. Wells High-resolution epitope mapping of hGH-receptor interactions by alanine-scanning mutagenesis Science 244 1989 1081 1085
11. C. Grefen, K. Städele, K. Růzicka, P. Obrdlik, K. Harter, and J. Horák Subcellular localization and in vivo interactions of the Arabidopsis thaliana ethylene receptor family members Mol. Plant 1 2008 308 320
12. P. Guzmán, and J.R. Ecker Exploiting the triple response of Arabidopsis to identify ethylene-related mutants Plant Cell 2 1990 513 523
13. G.R. Hicks, and N.V. Raikhel Specific binding of nuclear localization sequences to plant nuclei Plant Cell 5 1993 983 994
14. J. Hua, and E.M. Meyerowitz Ethylene responses are negatively regulated by a receptor gene family in Arabidopsis thaliana Cell. 94 1998 261 271
15. J. Hua, C. Chang, Q. Sun, and E.M. Meyerowitz Ethylene insensitivity conferred by Arabidopsis ERS gene Science 269 1995 1712 1714
16. J. Hua, H. Sakai, S. Nourizadeh, Q.G. Chen, A.B. Bleecker, J.R. Ecker, and E.M. Meyerowitz EIN4 and ERS2 are members of the putative ethylene receptor gene family in Arabidopsis Plant Cell 10 1998 1321 1332
17. P.R. Johnson, and J.R. Ecker The ethylene gas signal transduction pathway: a molecular perspective Annu. Rev. Genet. 32 1998 227 254
18. C. Ju, G.M. Yoon, J.M. Shemansky, D.Y. Lin, Z.I. Ying, J. Chang, W.M. Garrett, M. Kessenbrock, G. Groth, M.L. Tucker, and et al. CTR1 phosphorylates the central regulator EIN2 to control ethylene hormone signaling from the ER membrane to the nucleus in Arabidopsis Proc. Natl. Acad. Sci. USA 109 2012 19486 19491
19. C. Ju, B. Van de Poel, E.D. Cooper, J.H. Thierer, T.R. Gibbons, C.F. Delwiche, and C. Chang Conservation of ethylene as a plant hormone over 450 million years of evolution Nat. Plants 1 2015 14004
20. S. Kosugi, M. Hasebe, N. Matsumura, H. Takashima, E. Miyamoto-Sato, M. Tomita, and H. Yanagawa Six classes of nuclear localization signals specific to different binding grooves of importin alpha J. Biol. Chem. 284 2009 478 485
21. T.G. Lonhienne, Y. Trusov, A. Young, D. Rentsch, T. Näsholm, S. Schmidt, and C. Paungfoo-Lonhienne Effects of externally supplied protein on root morphology and biomass allocation in Arabidopsis Sci. Rep. 4 2014 5055
22. N. Panchuk-Voloshina, R.P. Haugland, J. Bishop-Stewart, M.K. Bhalgat, P.J. Millard, F. Mao, W.Y. Leung, and R.P. Haugland Alexa dyes, a series of new fluorescent dyes that yield exceptionally bright, photostable conjugates J. Histochem. Cytochem. 47 1999 1179 1188
23. C. Paungfoo-Lonhienne, T.G. Lonhienne, D. Rentsch, N. Robinson, M. Christie, R.I. Webb, H.K. Gamage, B.J. Carroll, P.M. Schenk, and S. Schmidt Plants can use protein as a nitrogen source without assistance from other organisms Proc. Natl. Acad. Sci. USA 105 2008 4524 4529
24. H. Qiao, Z. Shen, S.S. Huang, R.J. Schmitz, M.A. Urich, S.P. Briggs, and J.R. Ecker Processing and subcellular trafficking of ER-tethered EIN2 control response to ethylene gas Science 338 2012 390 393
25. H. Sakai, J. Hua, Q.G. Chen, C. Chang, L.J. Medrano, A.B. Bleecker, and E.M. Meyerowitz ETR2 is an ETR1-like gene involved in ethylene signaling in Arabidopsis Proc. Natl. Acad. Sci. USA 95 1998 5812 5817
26. B. Scharein, J. Voet-van-Vormizeele, K. Harter, and G. Groth Ethylene signaling: identification of a putative ETR1-AHP1 phosphorelay complex by fluorescence spectroscopy Anal. Biochem. 377 2008 72 76
27. B. Tinland, Z. Koukolíková-Nicola, M.N. Hall, and B. Hohn The T-DNA-linked VirD2 protein contains two distinct functional nuclear localization signals Proc. Natl. Acad. Sci. USA 89 1992 7442 7746
28. J. Voet-van-Vormizeele, and G. Groth Ethylene controls autophosphorylation of the histidine kinase domain in ethylene receptor ETR1 Mol. Plant 1 2008 380 387
29. X. Wen, C. Zhang, Y. Ji, Q. Zhao, W. He, F. An, L. Jiang, and H. Guo Activation of ethylene signaling is mediated by nuclear translocation of the cleaved EIN2 carboxyl terminus Cell Res. 22 2012 1613 1616