Incidence and Causes of Aconitum Alkaloid Poisoning in Hong Kong from 1989 to 2010

Phytotherapy Research

Volumn 29, Issue 8, 2015, Pages 1107-1111

  Chan, Thomas Y K ^a,b  

^a and Hong Kong Branch of CAS Center for Excellence in Animal Evolution and Genetics   (Hong Kong)

^b CHINESE UNIVERSITY OF HONG KONG   (Hong Kong)

Author keywords

aconite poisoning; aconite roots; Aconitum alkaloids; Hong Kong; traditional medicine

Indexed keywords

ALKALOID; HERBACEOUS AGENT; NEUROTOXIN;

ACONITE; ACONITUM ALKALOID POISONING; HEALTH PROMOTION; HONG KONG; HUMAN; INTOXICATION; MONITORING; MORBIDITY; PLANT ROOT; REVIEW; SAFETY; DRUG CONTAMINATION; EPIDEMIOLOGY; INCIDENCE;

ACONITUM;

ACONITUM; ALKALOIDS; DRUG CONTAMINATION; DRUGS, CHINESE HERBAL; HONG KONG; HUMANS; INCIDENCE; NEUROTOXINS; PLANT ROOTS;

EID: 84938747462     PISSN: 0951418X     EISSN: 10991573     Source Type: Journal    
DOI: 10.1002/ptr.5370     Document Type: Review

References (26)

1. Chan TYK,. 1994. Aconitine poisoning: a global perspective. Vet Hum Toxicol 36: 326-328.
2. Chan TYK,. 1997. Monitoring the safety of herbal medicines. Drug Saf 17: 209-215.
3. Chan TYK,. 2002. Incidence of herb-induced aconitine poisoning in Hong Kong: impact of publicity measures to promote awareness among the herbalists and the public. Drug Saf 25: 823-828.
4. Chan TYK,. 2009. Aconite poisoning. Clin Toxicol 47: 279-285.
5. Chan TYK,. 2010. Hidden aconite roots in herbal medicines [letter]. Clin Toxicol 48: 92.
6. Chan TYK,. 2011. Causes and prevention of herb-induced aconite poisonings in Asia. Hum Exp Toxicol 30: 2023-2026.
7. Chan TYK,. 2012a. Aconitum alkaloid content and the high toxicity of aconite tincture. Forensic Sci Int 222: 1-3.
8. Chan TYK,. 2012b. Aconite poisoning following the percutaneous absorption of Aconitum alkaloids. Forensic Sci Int 223: 25-27.
9. Chan TYK,. 2012c. Contributory factors in herb-induced fatal aconite poisoning. Forensic Sci Int 223: 40-43.
10. Chan TYK,. 2014. Aconitum alkaloid poisoning related to the culinary uses of aconite roots. Toxins 6: 2605-2611.
11. Chan TYK, Chan JCN, Tomlinson B, Critchley JAJH,. 1993. Chinese herbal medicines revisited: a Hong Kong perspective. Lancet 342: 1532-1534.
12. Chan TYK, Tomlinson B, Tse LKK, Chan JCN, Chan WWM, Critchley JAJH,. 1994. Aconitine poisoning due to Chinese herbal medicines: a review. Vet Hum Toxicol 36: 452-455.
13. Chan TYK, Tam HP, Lai CK, Chan AYW,. 2005. A multidisciplinary approach to the toxicological problems associated with the use of herbal medicines. Ther Drug Monit 27: 53-57.
14. Chan TYK, Wong RSM, Mak TWL, Chan JCM, Wong GWK, Chan AYW,. 2013. Aconite poisoning following the consumption of herbal soup [abstract]. Clin Toxicol 51: 268.
15. Chen SPL, Ng SW, Poon WT, et al,. 2012. Aconite poisoning over 5 years: a case series in Hong Kong and lessons towards herbal safety. Drug Saf 35: 575-587.
16. Chung KKW, Chen SPL, Ng SW, Mak TWL, Leung KSY,. 2012. Measurement of yunaconitine and crassicauline A in small-volume blood serum samples by LC-MS MS-tracing of aconite poisoning in clinical diagnosis. Talanta 97: 491-498.
17. Department of Health. 2011. Aconitine poisoning. Poisoning Watch 4: 1-7.
18. Lai CK, Poon WT, Chan YW,. 2004. Hidden aconite poisoning: identification of yunaconitine and related Aconitum alkaloids in urine by liquid chromatography-tandem mass spectrometry. J Anal Toxicol 30: 426-433.
19. Lin CC, Chan TYK, Deng JF,. 2004. Clinical features and management of herb-induced aconitine poisoning. Ann Emerg Med 43: 574-579.
20. Ou SP, Zheng Q, Wang S, Yue PF, Chen ZH, Yang M,. 2012. Study on dynamic differences of alkaloid in various tissues of Aconitum. Chinese J Exp Tradit Med Formulae 18: 83-87.
21. Poon WT, Lai CK, Ching CK, et al,. 2006. Aconite poisoning in camouflage. Hong Kong Med J 12: 456-459.
22. Sin J, Chan C,. 2004. Review of adverse events related to Chinese medicines in Hong Kong, January 2000-June 2004. Public Health Epidemiol Bul 13: 60-66.
23. Tai YT, But PPH, Young K, Lau CP,. 1992. Cardiotoxicity after accidental herb-induced aconite poisoning. Lancet 340: 1254-1256.
24. Tsoi OL, Yuen KY, Leung J, Lam R,. 2012. A six-year review of adverse events related to yunaconitine and crassicauline A (2006-2011) in Hong Kong [abstract]. Pharmacoepidemiol Drug Saf 21 (Suppl. 3): 222.
25. Wong A, Chan C,. 2005. Review of adverse events related to Chinese medicines in Hong Kong, July 2004-June 2005. Public Health Epidemiol Bull 14: 45-51.
26. Xiao PG, Wang FP, Gao F, Yan LP, Chen DL, Liu Y,. 2006. A pharmacophylogenetic study of Aconitum L. (Ranunculaceae) from China. Acta Phytotax Sin 44: 1-46.