Norbin ablation results in defective adult hippocampal neurogenesis and depressive-like behavior in mice

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 31, 2015, Pages 9745-9750

  Wang, Hong ^a   Warner Schmidt, Jennifer ^a   Varela, Santiago ^a   Enikolopov, Grigori ^b   Greengard, Paul ^a   Flajolet, Marc ^a  

^a ROCKEFELLER UNIVERSITY   (United States)

^b Simons Center for Quantitative Biology   (United States)

Author keywords

Glutamate; Major depressive disorder; MGluR5; Neurogenesis; Norbin

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II; CALCIUM CALMODULIN DEPENDENT PROTEIN KINASE II ALPHA; CRE RECOMBINASE; DESMOPLAKIN; DOUBLECORTIN; GLIAL FIBRILLARY ACIDIC PROTEIN; KI 67 ANTIGEN; METABOTROPIC RECEPTOR 5; NEURITE PROMOTING FACTOR; NORBIN; UNCLASSIFIED DRUG; NEUROPEPTIDE;

ADULT; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ADHESION; CELL CONTACT; CELL DENSITY; CELL FATE; CELL MATURATION; CELL MIGRATION; CELL PROLIFERATION; CELL SURVIVAL; CONTROLLED STUDY; DENTATE GYRUS; DOWN REGULATION; FORCED SWIM TEST; GENE DELETION; IMMOBILITY; LOCOMOTION; MAJOR DEPRESSION; MALE; MOUSE; NERVOUS SYSTEM DEVELOPMENT; NEURAL STEM CELL; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; SUCROSE PREFERENCE TEST; SURFACE PROPERTY; TAIL SUSPENSION TEST; UPREGULATION; AGING; ANIMAL; ANIMAL BEHAVIOR; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINEAGE; DEPRESSION; HIPPOCAMPUS; KNOCKOUT MOUSE; METABOLISM; MOTOR ACTIVITY; PATHOLOGY; PATHOPHYSIOLOGY; PHENOTYPE;

MUS;

AGING; ANIMALS; BEHAVIOR, ANIMAL; BRAIN-DERIVED NEUROTROPHIC FACTOR; CELL COMMUNICATION; CELL DIFFERENTIATION; CELL LINEAGE; CELL PROLIFERATION; DENTATE GYRUS; DEPRESSION; GENE DELETION; HIPPOCAMPUS; MICE, KNOCKOUT; MOTOR ACTIVITY; NEURAL STEM CELLS; NEUROGENESIS; NEUROPEPTIDES; PHENOTYPE; RECEPTOR, METABOTROPIC GLUTAMATE 5;

EID: 84938703728     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1510291112     Document Type: Article

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