Serum CRP and urinary trypsin inhibitor implicate postoperative cognitive dysfunction especially in elderly patients

International Journal of Neuroscience

Volumn 125, Issue 7, 2015, Pages 501-506

  Zhang, Yan Hua ^a   Guo, Xiu Hai ^b   Zhang, Qing Ming ^a   Yan, Guang Tao ^c   Wang, Tian Long ^a  

^a CAPITAL MEDICAL UNIVERSITY   (China)

^b Department of Neurology ^*  (China)

^c CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

elderly; inflammatory cytokines; POCD; urinary trypsin inhibitor

Indexed keywords

C REACTIVE PROTEIN; CREATININE; GELATINASE B; INTERLEUKIN 10; INTERLEUKIN 6; ULINASTATIN; GLYCOPROTEIN;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; CREATININE URINE LEVEL; ENZYME INHIBITION ASSAY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; INTERVERTEBRAL DISKECTOMY; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; MONTREAL COGNITIVE ASSESSMENT; POSTOPERATIVE COGNITIVE DYSFUNCTION; PROTEIN BLOOD LEVEL; RISK FACTOR; AGING; ANALYSIS OF VARIANCE; BLOOD; COGNITION DISORDERS; MENTAL HEALTH; METABOLISM; NEUROPSYCHOLOGICAL TEST; PATHOPHYSIOLOGY; POSTOPERATIVE COMPLICATION; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; AGING; ANALYSIS OF VARIANCE; C-REACTIVE PROTEIN; COGNITION DISORDERS; FEMALE; GLYCOPROTEINS; HUMANS; INTERLEUKIN-10; INTERLEUKIN-6; MALE; MATRIX METALLOPROTEINASE 9; MENTAL STATUS SCHEDULE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; POSTOPERATIVE COMPLICATIONS;

EID: 84938697146     PISSN: 00207454     EISSN: 15635279     Source Type: Journal    
DOI: 10.3109/00207454.2014.949341     Document Type: Article

References (19)

1. Ramaiah R, Lam AM. Postoperative cognitive dysfunction in the elderly. Anesthesiol Clin 2009; 27: 485-96.
2. Kiecolt-Glaser JK, Preacher KJ, MacCallum RC, et al. Chronic stress and age-related increases in the proinflammatory cytokine IL-6. Proc Natl Acad Sci USA 2003; 100: 9090-5.
3. Hu Z, Ou Y, Duan K, Jiang X. Inflammation: a bridge between postoperative cognitive dysfunction and Alzheimer's disease. Med Hypotheses 2010; 74: 722-4.
4. Sparkman NL, Johnson RW. Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress. Neuroimmunomodulation 2008; 15: 323-30.
5. de Rooij SE, van Munster BC, Korevaar JC, Levi M. Cytokines and acute phase response in delirium. J Psychosom Res 2007; 62: 521-5.
6. Terrando N, Monaco C, Ma D, et al. Tumor necrosis factor-alpha triggers a cytokine cascade yielding postoperative cognitive decline. Proc Natl Acad Sci USA 2010; 107: 20518-22.
7. van Munster BC, Korevaar JC, Zwinderman AH, et al. Time-course of cytokines during delirium in elderly patients with hip fractures. J Am Geriatr Soc 2008; 56: 1704-9.
8. Dantzer R, Konsman JP, Bluthe RM, Kelley KW. Neural and humoral pathways of communication from the immune system to the brain: parallel or convergent? Auton Neurosci 2000; 85: 60-5.
9. McCusker RH, Kelley KW. Immune-neural connections: how the immune system's response to infectious agents influences behavior. J Exp Biol 2013; 216: 84-98.
10. Rosell A, Cuadrado E, Ortega-Aznar A, et al. MMP-9-positive neutrophil infiltration is associated to blood-brain barrier breakdown and basal lamina type IV collagen degradation during hemorrhagic transformation after human ischemic stroke. Stroke 2008; 39: 1121-6.
11. Pugia MJ, Jortani SA, Basu M, et al. Immunological evaluation of urinary trypsin inhibitors in blood and urine: role of N-& O-linked glycoproteins. Glycoconj J 2007; 24: 5-15.
12. Pugia MJ, Takemura T, Kuwajima S, et al. Clinical utility of a rapid test for uristatin. Clin Biochem 2002; 35: 105-10.
13. Monk TG, Price CC. Postoperative cognitive disorders. Curr Opin Crit Care 2011; 17: 376-81.
14. Nasreddine ZS, Phillips NA, Bedirian V, et al. The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment. J Am Geriatr Soc 2005; 53: 695-9.
15. Beloosesky Y, Hendel D, Weiss A, et al. Cytokines and C-reactive protein production in hip-fracture-operated elderly patients. J Gerontol A Biol Sci Med Sci 2007; 62: 420-6.
16. Du Clos TW, Mold C. C-reactive protein: an activator of innate immunity and a modulator of adaptive immunity. Immunol Res 2004; 30: 261-77.
17. Krenk L, Rasmussen LS. Postoperative delirium and postoperative cognitive dysfunction in the elderly-what are the differences? Minerva Anestesiol 2011; 77: 742-9.
18. Hu X, Zhang M, Leak RK, et al. Delivery of neurotherapeutics across the blood brain barrier in stroke. Curr Pharm Des 2012; 18: 3704-20.
19. Rundshagen I. Postoperative cognitive dysfunction. Dtsch Arztebl Int 111: 119-25.