Richter transformation with c-MYC overexpression: Report of three cases

International Journal of Clinical and Experimental Pathology

Volumn 8, Issue 6, 2015, Pages 7540-7546

  Wang, Ling ^a   Aghel, Azadeh ^a   Peterson, Brandon ^b   Wang Rodriguez, Jessica ^a,c   Wang, Huan You ^a   Zhao, Xianfeng Frank ^a,c  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b NAVAL MEDICAL CENTER SAN DIEGO   (United States)

^c VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

Chronic lymphocytic leukemia small lymphocytic lymphoma; Diffuse large B cell lymphoma; MYC; Richter syndrome

Indexed keywords

MYC PROTEIN; MYC PROTEIN, HUMAN; TUMOR MARKER;

AGED; CASE REPORT; CELL TRANSFORMATION; CHEMISTRY; FATALITY; FEMALE; FLUORESCENCE IN SITU HYBRIDIZATION; GENE REARRANGEMENT; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOMA, LARGE B-CELL, DIFFUSE; MALE; METABOLISM; MIDDLE AGED; PATHOLOGY; TIME FACTOR; TREATMENT OUTCOME; UPREGULATION; VERY ELDERLY;

AGED; AGED, 80 AND OVER; BIOMARKERS, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; FATAL OUTCOME; FEMALE; GENE REARRANGEMENT; HUMANS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION, FLUORESCENCE; LEUKEMIA, LYMPHOCYTIC, CHRONIC, B-CELL; LYMPHOMA, LARGE B-CELL, DIFFUSE; MALE; MIDDLE AGED; PROTO-ONCOGENE PROTEINS C-MYC; TIME FACTORS; TREATMENT OUTCOME; UP-REGULATION;

EID: 84938634507     PISSN: None     EISSN: 19362625     Source Type: Journal    
DOI: None     Document Type: Article

References (18)

1. Cheson BD, Bennett JM, Grever M, Kay N, Keating MJ, O'Brien S and Rai KR. National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment. Blood 1996; 87: 4990-4997.
2. Rossi D and Gaidano G. Richter syndrome: molecular insights and clinical perspectives. Hematol Oncol 2009; 27: 1-10.
3. Tsimberidou AM and Keating MJ. Richter syndrome: biology, incidence, and therapeutic strategies. Cancer 2005; 103: 216-228.
4. Rossi D, Spina V, Deambrogi C, Rasi S, Laurenti L, Stamatopoulos K, Arcaini L, Lucioni M, Rocque GB, Xu-Monette ZY, Visco C, Chang J, Chigrinova E, Forconi F, Marasca R, Besson C, Papadaki T, Paulli M, Larocca LM, Pileri SA, Gattei V, Bertoni F, Foà R, Young KH and Gaidano G. The genetics of Richter syndrome reveals disease heterogeneity and predicts survival after transformation. Blood 2011; 117: 3391-3401.
5. Swords R, Bruzzi J and Giles F. Recent advances in the diagnosis and therapy of Richter's syndrome. Med Oncol 2007; 24: 17-32.
6. Parikh SA, Kay NE and Shanafelt TD. How we treat Richter syndrome. Blood 2014; 123: 1647-57.
7. Scandurra M, Rossi D, Deambrogi C, Rancoita PM, Chigrinova E, Mian M, Cerri M, Rasi S, Sozzi E, Forconi F, Ponzoni M, Moreno SM, Piris MA, Inghirami G, Zucca E, Gattei V, Rinaldi A, Kwee I, Gaidano G and Bertoni F. Genomic profiling of Richter's syndrome: recurrent lesions and differences with de novo diffuse large B-cell lymphomas. Hematol Oncol 2010; 28: 62-67.
8. Huh YO, Lin KI, Vega F, Schlette E, Yin CC, Keating MJ, Luthra R, Medeiros LJ and Abruzzo LV. MYC translocation in chronic lymphocytic leukaemia is associated with increased prolymphocytes and a poor prognosis. Brit J Haematol 2008; 142: 36-44.
9. Dang CV. MYC on the path to cancer. Cell 2012; 149: 22-35.
10. Lin P, Medeiros LJ. High-grade B-cell lymphoma/leukemia associated with t(14;18) and 8q24/MYC rearrangement: a neoplasm of germinal center immunophenotype with poor prognosis. Haematologica 2007; 92: 1297-1301.
11. Hao S, Sanger W, Onciu M, Lai R, Schlette EJ, Medeiros LJ. Mantle cell lymphoma with 8q24 chromosomal abnormalities: a report of 5 cases with blastoid features. Mod Pathol 2002; 15: 1266-1272.
12. Lossos IS, Alizadeh AA, Diehn M, Warnke R, Thorstenson Y, Oefner PJ, Brown PO, Botstein D and Levy R. Transformation of follicular lymphoma to diffuse large-cell lymphoma: alternative patterns with increased or decreased expression of c-myc and its regulated genes. Proc Natl Acad Sci U S A 2002; 99: 8886-8891.
13. Kuriakose P, Perveen N, Maeda K, Wiktor A, Van Dyke DL. Translocation (8;14)(q24;q32) as the sole cytogenetic abnormality in B-cell prolymphocytic leukemia. Cancer Genet Cytogenet 2004; 150: 156-158.
14. Johnson NA, Slack GW, Savage KJ, Connors JM, Ben-Neriah S, Rogic S, Scott DW, Tan KL, Steidl C, Sehn LH, Chan WC, Iqbal J, Meyer PN, Lenz G, Wright G, Rimsza LM, Valentino C, Brunhoeber P, Grogan TM, Braziel RM, Cook JR, Tubbs RR, Weisenburger DD, Campo E, Rosenwald A, Ott G, Delabie J, Holcroft C, Jaffe ES, Staudt LM and Gascoyne RD. Concurrent expression of MYC and BCL2 in diffuse large B-cell lymphoma treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone. J Clin Oncol 2012; 30: 3452-3459.
15. Seiler T, Dohner H and Stilgenbauer S. Risk stratification in chronic lymphocytic leukemia. Semin Oncol 2006; 33: 186-194.
16. Cuneo A, Bigoni R, Negrini M, Bullrich F, Veronese ML, Roberti MG, Bardi A, Rigolin GM, Cavazzini P, Croce CM and Castoldi G. Cytogenetic and interphase cytogenetic characterization of atypical chronic lymphocytic leukemia carrying BCL1 translocation. Cancer Res 1997; 57: 1144-1150.
17. Cobo F, Martínez A, Pinyol M, Hernández L, Gómez M, Beá S, Esteve J, Rozman M, Bosch F, López-Guillermo A, Montserrat E and Campo E. Multiple cell cycle regulator alterations in Richter's transformation of chronic lymphocytic leukemia. Leukemia 2002; 16: 1028-34.
18. Vela-Chavez T, Adam P, Kremer M, Bink K, Bacon CM, Menon G, Ferry JA, Fend F, Jaffe ES and Quintanilla-Martínez L. Cyclin D1 positive diffuse large B-cell lymphoma is a post-germinal center-type lymphoma without alterations in the CCND1 gene locus. Leuk Lymph 2011; 52: 458-466.