Complement membrane attack complexes activate noncanonical NF-κB by forming an Akt+NIK+ signalosome on Rab5+ endosomes

Proceedings of the National Academy of Sciences of the United States of America

Volumn 112, Issue 31, 2015, Pages 9686-9691

  Jane wit, Dan ^a   Surovtseva, Yulia V ^b   Qin, Lingfeng ^a   Li, Guangxin ^a   Liu, Rebecca ^a   Clark, Pamela ^a   Manes, Thomas D ^a   Wang, Chen ^a   Kashgarian, Michael ^a   Kirkiles Smith, Nancy C ^a   Tellides, George ^a   Pober, Jordan S ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b YALE UNIVERSITY   (United States)

Author keywords

Complement; Endothelial cell; Inflammation; Membrane attack complex; Signaling

Indexed keywords

CELL ADHESION MOLECULE; COMPLEMENT MEMBRANE ATTACK COMPLEX; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NIK PROTEIN; PROTEIN; PROTEIN KINASE B; RAB PROTEIN; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 3; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; BIRC3 PROTEIN, HUMAN; CLATHRIN; HYDRAZONE DERIVATIVE; INHIBITOR OF APOPTOSIS PROTEIN; N'-(3,4-DIHYDROXYBENZYLIDENE)-3-HYDROXY-2-NAPHTHAHYDRAZIDE; NF-KAPPA B KINASE; PROTEIN SERINE THREONINE KINASE; SMALL INTERFERING RNA; UBIQUITIN PROTEIN LIGASE;

ANIMAL EXPERIMENT; ARTICLE; CONFOCAL MICROSCOPY; CONTROLLED STUDY; CORONARY ARTERY; ENDOCYTOSIS; ENDOSOME; FEMALE; GENE INDUCTION; HUMAN; IN VITRO STUDY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; SIGNAL TRANSDUCTION; ANIMAL; CORONARY BLOOD VESSEL; DRUG EFFECTS; ENZYME STABILITY; FLOW CYTOMETRY; METABOLISM; PROTEIN SYNTHESIS; SCID MOUSE; SECRETORY VESICLE; UMBILICAL VEIN ENDOTHELIAL CELL;

ANIMALS; CLATHRIN; COMPLEMENT MEMBRANE ATTACK COMPLEX; CORONARY VESSELS; ENDOCYTOSIS; ENDOSOMES; ENZYME STABILITY; FLOW CYTOMETRY; HUMAN UMBILICAL VEIN ENDOTHELIAL CELLS; HUMANS; HYDRAZONES; INHIBITOR OF APOPTOSIS PROTEINS; MICE, SCID; NF-KAPPA B; PROTEIN BIOSYNTHESIS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS C-AKT; RAB5 GTP-BINDING PROTEINS; RNA, SMALL INTERFERING; SECRETORY VESICLES; SIGNAL TRANSDUCTION; TNF RECEPTOR-ASSOCIATED FACTOR 3; UBIQUITIN-PROTEIN LIGASES;

EID: 84938632052     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1503535112     Document Type: Article

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