Tumor-induced pressure in the bone microenvironment causes osteocytes to promote the growth of prostate cancer bone metastases

Cancer Research

Volumn 75, Issue 11, 2015, Pages 2151-2158

  Sottnik, Joseph L ^a   Dai, Jinlu ^a   Zhang, Honglai ^a   Campbell, Brittany ^a   Keller, Evan T ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BATIMASTAT; GELATINASE A; GELATINASE B; MATRIX METALLOPROTEINASE; RANTES; CCL5 PROTEIN, HUMAN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BONE METASTASIS; BONE PRESSURE; BONE REMODELING; CANCER GROWTH; CCL5 GENE; CELL VIABILITY; CONTROLLED STUDY; CORTICAL BONE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; GENE EXPRESSION; HYDROSTATIC PRESSURE; IN VITRO STUDY; IN VIVO STUDY; MALE; MMP2 GENE; MMP9 GENE; MOUSE; NONHUMAN; OSTEOCYTE; OSTEOLYSIS; PRESSURE; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN EXPRESSION; PROTEIN FUNCTION; TUMOR GROWTH; TUMOR INVASION; TUMOR MICROENVIRONMENT; UPREGULATION; ANIMAL; BIOSYNTHESIS; BONE TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; METASTASIS; PATHOLOGY; PHYSIOLOGY; PROSTATE TUMOR; SECONDARY;

ANIMALS; BONE NEOPLASMS; CELL PROLIFERATION; CHEMOKINE CCL5; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MALE; MATRIX METALLOPROTEINASES; MICE; NEOPLASM METASTASIS; OSTEOCYTES; PRESSURE; PROSTATIC NEOPLASMS; TUMOR MICROENVIRONMENT;

EID: 84938626000     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-14-2493     Document Type: Article

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