Impact of Daily Cotrimoxazole on Clinical Malaria and Asymptomatic Parasitemias in HIV-Exposed, Uninfected Infants

Clinical Infectious Diseases

Volumn 61, Issue 3, 2015, Pages 368-374

  Davis, Nicole L ^a,b   Barnett, Eric J ^b   Miller, William C ^a,b   Dow, Anna ^a   Chasela, Charles S ^c   Hudgens, Michael G ^a   Kayira, Dumbani ^d   Tegha, Gerald ^d   Ellington, Sascha R ^e   Kourtis, Athena P ^e   Van Der Horst, Charles ^b   Jamieson, Denise J ^e   Juliano, Jonathan J ^b  

^a University of North Carolina at Chapel Hill   (United States)

^b UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^d UNIVERSITY OF NORTH CAROLINA PROJECT   (Malawi)

^e NATIONAL CENTER FOR CHRONIC DISEASE PREVENTION AND HEALTH PROMOTION   (United States)

Author keywords

antifolate resistance; cotrimoxazole; HIV; infant; malaria

Indexed keywords

ARTEMETHER PLUS BENFLUMETOL; CHLOROQUINE; COTRIMOXAZOLE; DIHYDROFOLATE REDUCTASE; DIHYDROPTEROATE SYNTHASE; NEVIRAPINE; PYRIMETHAMINE PLUS SULFADOXINE; ANTIMALARIAL AGENT;

ALLELE; ASYMPTOMATIC INFECTION; BREAST FEEDING; CD4 LYMPHOCYTE COUNT; COHORT ANALYSIS; DRIED BLOOD SPOT TESTING; DRUG SUBSTITUTION; FEMALE; GENE FREQUENCY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; INFANT; INFANT DISEASE; MAJOR CLINICAL STUDY; MALARIA FALCIPARUM; MALAWI; MALE; OBSERVATIONAL STUDY; OPPORTUNISTIC INFECTION; PLASMODIUM FALCIPARUM; PRIORITY JOURNAL; REVIEW; RISK REDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; DRUG EFFECTS; DRUG RESISTANCE; GENETICS; MALARIA; PARASITEMIA; PARASITOLOGY; RANDOMIZATION;

ANTIMALARIALS; ASYMPTOMATIC INFECTIONS; DRUG RESISTANCE; FEMALE; HIV INFECTIONS; HUMANS; INFANT; MALARIA; MALAWI; MALE; PARASITEMIA; PLASMODIUM FALCIPARUM; RANDOM ALLOCATION; TRIMETHOPRIM, SULFAMETHOXAZOLE DRUG COMBINATION;

EID: 84938585983     PISSN: 10584838     EISSN: 15376591     Source Type: Journal    
DOI: 10.1093/cid/civ309     Document Type: Review

References (30)

1. World Health Organization, United Nations Children's Fund. Cotrimoxazole prophylaxis for HIV-exposed and HIV-infected infants and children: practical approaches to implementation and scale up. Geneva, Switzerland: WHO/UNICEF, 2009.
2. Anglaret X, Chene G, Attia A, et al. Early chemoprophylaxis with trimethoprim-sulphamethoxazole for HIV-1-infected adults in Abidjan, Cote D'Ivoire: a randomised trial. Cotrimo-CI Study Group. Lancet 1999; 353:1463-8.
3. Mermin J, Ekwaru JP, Liechty CA, et al. Effect of co-trimoxazole prophylaxis, antiretroviral therapy, and insecticide-treated bednets on the frequency of malaria in HIV-1-infected adults in Uganda: a prospective cohort study. Lancet 2006; 367:1256-61.
4. Kamya MR, Gasasira AF, Achan J, et al. Effects of trimethoprimsulfamethoxazole and insecticide-treated bednets on malaria among HIV-infected Ugandan children. AIDS 2007; 21:2059-66.
5. Dow A, Kayira D, Hudgens M, et al. Effects of cotrimoxazole prophylactic treatment on adverse health outcomes among HIV-exposed, uninfected infants. Pediatr Infect Dis J 2012; 31:842-7.
6. Kamya MR, Kapisi J, Bigira V, et al. Efficacy and safety of three regimens for the prevention of malaria in young HIV-exposed Ugandan children: a randomized controlled trial. AIDS 2014; 28:2701-9.
7. Mbeye NM, ter Kuile FO, Davies MA, et al. Cotrimoxazole prophylactic treatment prevents malaria in children in sub-Saharan Africa: systematic review and meta-analysis. Trop Med Int Health 2014; 19:1057-67.
8. Lin JT, Saunders DL, Meshnick SR. The role of submicroscopic parasitemia in malaria transmission: what is the evidence? Trends Parasitol 2014; 30:183-90.
9. Beshir KB, Sutherland CJ, Sawa P, et al. Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence. J Infect Dis 2013; 208:2017-24.
10. Chasela CS, Hudgens MG, Jamieson DJ, et al. Maternal or infant antiretroviral drugs to reduce HIV-1 transmission. N Engl J Med 2010; 362:2271-81.
11. van der Horst C, Chasela C, Ahmed Y, et al. Modifications of a large HIV prevention clinical trial to fit changing realities: a case study of the Breastfeeding, Antiretroviral, and Nutrition (BAN) protocol in Lilongwe, Malawi. Contemp Clin Trials 2009; 30:24-33.
12. Taylor SM, Juliano JJ, Trottman PA, et al. High-throughput pooling and real-time PCR-based strategy for malaria detection. J Clin Microbiol 2010; 48:512-9.
13. Bejon P, Williams TN, Nyundo C, et al. A micro-epidemiological analysis of febrile malaria in coastal Kenya showing hotspots within hotspots. Elife 2014; 3:e02130.
14. Sturrock HJ, Hsiang MS, Cohen JM, et al. Targeting asymptomatic malaria infections: active surveillance in control and elimination. PLoS Med 2013; 10:e1001467.
15. Greenland S, Pearl J, Robins JM. Causal diagrams for epidemiologic research. Epidemiology 1999; 10:37-48.
16. Pickard AL, Wongsrichanalai C, Purfield A, et al. Resistance to antimalarials in Southeast Asia and genetic polymorphisms in pfmdr1. Antimicrob Agents Chemother 2003; 47:2418-23.
17. World Health Organization. Recommended genotyping procedures (RGPs) to identify parasite populations. Available at: http://www.who. int/malaria/publications/atoz/rgptext-sti.pdf. Accessed 28 April 2015.
18. Taylor SM, Parobek CM, Aragam N, et al. Pooled deep sequencing of Plasmodium falciparum isolates: an efficient and scalable tool to quantify prevailing malaria drug-resistance genotypes. J Infect Dis 2013; 208:1998-2006.
19. Taylor SM, Parobek CM, DeConti DK, et al. Absence of putative Plasmodium falciparum artemisinin resistance mutations in sub-Saharan Africa: a molecular epidemiologic study. J Infect Dis 2015; 211:680-8.
20. World Health Organization. World malaria report 2014. Geneva, Switzerland: WHO, 2014.
21. Kourtis AP,Wiener J, Kayira D, et al. Health outcomes of HIV-exposed uninfected African infants. AIDS 2013; 27:749-59.
22. Nsobya SL, Parikh S, Kironde F, et al. Molecular evaluation of the natural history of asymptomatic parasitemia in Ugandan children. J Infect Dis 2004; 189:2220-6.
23. Magesa SM, Mdira KY, Babiker HA, et al. Diversity of Plasmodium falciparum clones infecting children living in a holoendemic area in northeastern Tanzania. Acta Trop 2002; 84:83-92.
24. Gudo ES, Prista A, Jani IV. Impact of asymptomatic Plasmodium falciparum parasitemia on the imunohematological indices among school children and adolescents in a rural area highly endemic for malaria in southern Mozambique. BMC Infect Dis 2013; 13:244.
25. Matangila JR, Lufuluabo J, Ibalanky AL, Inocencio da Luz RA, Lutumba P, Van Geertruyden JP. Asymptomatic Plasmodium falciparum infection is associated with anaemia in pregnancy and can be more costeffectively detected by rapid diagnostic test than by microscopy in Kinshasa, Democratic Republic of the Congo. Malar J 2014; 13:132.
26. Nwali MI, Umeora OU, Ozumba BC, Onoh RC, Agwu UM, Agboeze J. Outcomes of asymptomatic malaria parasitaemia in neonates in a tertiary hospital, southeast Nigeria. Niger Med J 2014; 55:250-3.
27. Khan WA, Galagan SR, Prue CS, et al. Asymptomatic Plasmodium falciparum malaria in pregnant women in the Chittagong Hill Districts of Bangladesh. PLoS One 2014; 9:e98442.
28. Lindblade KA, Steinhardt L, Samuels A, Kachur SP, Slutsker L. The silent threat: asymptomatic parasitemia and malaria transmission. Expert Rev Anti Infect Ther 2013; 11:623-39.
29. White NJ. The role of anti-malarial drugs in eliminating malaria. Malar J 2008; 7(suppl 1):S8.
30. Alves FP, Gil LH, Marrelli MT, Ribolla PE, Camargo EP, Da Silva LH. Asymptomatic carriers of Plasmodium spp. as infection source for malaria vector mosquitoes in the Brazilian Amazon. J Med Entomol 2005; 42:777-9.