Sub-lingual administration of a polyvalent mechanical bacterial lysate (PMBL) in patients with moderate, severe, or very severe chronic obstructive pulmonary disease (COPD) according to the GOLD spirometric classification: A multicentre, double-blind, randomised, controlled, phase IV study (AIACE study: Advanced Immunological Approach in COPD Exacerbation)

Pulmonary Pharmacology and Therapeutics

Volumn 33, Issue , 2015, Pages 75-80

  Braido, Fulvio ^a   Melioli, Giovanni ^a   Cazzola, Mario ^b   Fabbri, Leonardo ^c   Blasi, Francesco ^d   Moretta, Lorenzo ^e   Canonica, Giorgio Walter ^a  

^a UNIVERSITY OF GENOA   (Italy)

^b TOR VERGATA UNIVERSITY HOSPITAL   (Italy)

^c UNIVERSITY OF MODENA AND REGGIO EMILIA   (Italy)

^d UNIVERSITY OF MILAN   (Italy)

^e G GASLINI INSTITUTE   (Italy)

Author keywords

Bacterial lysate; Chronic obstructive pulmonary disease (COPD); Immune stimulation; Polyvalent mechanical bacterial lysate (PMBL)

Indexed keywords

ANTIBIOTIC AGENT; BACTERIUM LYSATE; PLACEBO; POLYVALENT MECHANICAL BACTERIAL LYSATE; UNCLASSIFIED DRUG; BRONCHO-VAXOM; CELL EXTRACT; IMMUNOLOGICAL ADJUVANT;

ADULT; AGED; ARTICLE; CHRONIC OBSTRUCTIVE LUNG DISEASE; CONTROLLED STUDY; DISEASE CLASSIFICATION; DISEASE EXACERBATION; DOUBLE BLIND PROCEDURE; FEMALE; FEVER; GOLD SPIROMETRIC CLASSIFICATION; HOSPITALIZATION; HUMAN; INTENTION TO TREAT ANALYSIS; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHASE 4 CLINICAL TRIAL; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SMOKING; SPIROMETRY; CLINICAL TRIAL; IMMUNOLOGY; MIDDLE AGED; PATHOPHYSIOLOGY; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SEVERITY OF ILLNESS INDEX; STATISTICS AND NUMERICAL DATA; TREATMENT OUTCOME;

ADJUVANTS, IMMUNOLOGIC; AGED; CELL EXTRACTS; DOUBLE-BLIND METHOD; FEMALE; FEVER; HOSPITALIZATION; HUMANS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; SEVERITY OF ILLNESS INDEX; SPIROMETRY; TREATMENT OUTCOME;

EID: 84938541217     PISSN: 10945539     EISSN: 15229629     Source Type: Journal    
DOI: 10.1016/j.pupt.2015.03.006     Document Type: Article

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