The SARS coronavirus papain like protease can inhibit IRF3 at a post activation step that requires deubiquitination activity

Virology Journal

Volumn 11, Issue 1, 2014, Pages

  Matthews, Krystal ^a   Schäfer, Alexandra ^b   Pham, Alissa ^c,d   Frieman, Matthew ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b IL   (United States)

^c MOUNT SINAI SCHOOL OF MEDICINE   (United States)

^d NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Coronavirus; Innate immunity; Interferon; IRF3; Severe acute respiratory syndrome

Indexed keywords

INTERFERON REGULATORY FACTOR 3; MUTANT PROTEIN; PAPAIN LIKE PROTETEASE; UNCLASSIFIED DRUG; VIRUS ENZYME; 3C-LIKE PROTEASE, SARS CORONAVIRUS; CYSTEINE PROTEINASE; IRF3 PROTEIN, HUMAN; UBIQUITIN; VIRUS PROTEIN;

ARTICLE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; DEUBIQUITINATION; DIMERIZATION; DNA BINDING; ENZYME ACTIVITY; GEL MOBILITY SHIFT ASSAY; GENETIC TRANSFECTION; IMMUNOREGULATION; INNATE IMMUNITY; INTERFERON INDUCTION; INTERFERON INDUCTION INHIBITION; MUTAGENESIS; NONHUMAN; PLASMID; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN PHOSPHORYLATION; SARS CORONAVIRUS; UBIQUITINATION; ANTAGONISTS AND INHIBITORS; CELL LINE; ENZYMOLOGY; HUMAN; METABOLISM;

CORONAVIRUS; SARS CORONAVIRUS;

CELL LINE; CHROMATIN IMMUNOPRECIPITATION; CYSTEINE ENDOPEPTIDASES; ELECTROPHORETIC MOBILITY SHIFT ASSAY; HUMANS; INTERFERON REGULATORY FACTOR-3; SARS VIRUS; TRANSFECTION; UBIQUITIN; VIRAL PROTEINS;

EID: 84938521107     PISSN: None     EISSN: 1743422X     Source Type: Journal    
DOI: 10.1186/s12985-014-0209-9     Document Type: Article

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