Regional patterns of grey matter atrophy and magnetisation transfer ratio abnormalities in multiple sclerosis clinical subgroups: A voxel-based analysis study

Multiple Sclerosis Journal

Volumn 21, Issue 4, 2015, Pages 423-432

  Mallik, Shahrukh ^a,b   Muhlert, Nils ^c   Samson, Rebecca S ^b   Sethi, Varun ^b   Wheeler Kingshott, Claudia Am ^b   Miller, David H ^b   Chard, Declan T ^b  

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

atrophy; demyelination; grey matter; magnetisation transfer ratio; Multiple sclerosis; voxel based analysis

Indexed keywords

ADULT; AGE DISTRIBUTION; ARTICLE; BRAIN ATROPHY; BRAIN SIZE; CONTROLLED STUDY; DATA ANALYSIS SOFTWARE; DEMYELINATION; FEMALE; GREY MATTER ATROPHY; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTIPLE SCLEROSIS; SEX DIFFERENCE; VOXEL BASED MORPHOMETRY; ATROPHY; BRAIN; COMPUTER ASSISTED DIAGNOSIS; DEMYELINATING DISEASE; GRAY MATTER; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOLOGY;

ADULT; ATROPHY; BRAIN; DEMYELINATING DISEASES; FEMALE; GRAY MATTER; HUMANS; IMAGE INTERPRETATION, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; MALE; MULTIPLE SCLEROSIS;

EID: 84938483702     PISSN: 13524585     EISSN: 14770970     Source Type: Journal    
DOI: 10.1177/1352458514546513     Document Type: Article

References (42)

1. Geurts JJG, Barkhof F. Grey matter pathology in multiple sclerosis. Lancet Neurol. 2008 ; 7: 841-851
2. Lucchinetti CF, Popescu BFG, Bunyan RF, et al. Inflammatory cortical demyelination in early multiple sclerosis. N Engl J Med. 2011 ; 365: 2188-2197
3. Kutzelnigg A, Lucchinetti CF, Stadelmann C, et al. Cortical demyelination and diffuse white matter injury in multiple sclerosis. Brain. 2005 ; 128: 2705-2712
4. Popescu BFG, Lucchinetti CF. Meningeal and cortical grey matter pathology in multiple sclerosis. BMC Neurol. 2012 ; 12: 11
5. Vercellino M, Masera S, Lorenzatti M, et al. Demyelination, inflammation, and neurodegeneration in multiple sclerosis deep gray matter. J Neuropathol Exp Neurol. 2009 ; 68: 489-502
6. Wegner C, Esiri M, Chance S.. Neocortical neuronal, synaptic, and glial loss in multiple sclerosis. Neurology. 2006 ; 67: 960-967
7. Magliozzi R, Howell OW, Reeves C, et al. A Gradient of neuronal loss and meningeal inflammation in multiple sclerosis. Ann Neurol. 2010 ; 68: 477-493
8. Choi SR, Howell OW, Carassiti D, et al. Meningeal inflammation plays a role in the pathology of primary progressive multiple sclerosis. Brain. 2012 ; 135: 2925-2937
9. Magliozzi R, Howell O, Vora A, et al. Meningeal B-cell follicles in secondary progressive multiple sclerosis associate with early onset of disease and severe cortical pathology. Brain. 2007 ; 130: 1089-104
10. Howell OW, Reeves C, Nicholas R, et al. Meningeal inflammation is widespread and linked to cortical pathology in multiple sclerosis. Brain. 2011 ; 134: 2755-2771
11. Miller DH, Barkhof F, Frank J, et al. Measurement of atrophy in multiple sclerosis: Pathological basis, methodological aspects and clinical relevance. Brain. 2002 ; 125: 1676-1695
12. Bonati U, Fisniku LK, Altmann DR, et al. Cervical cord and brain grey matter atrophy independently associate with long-term MS disability. J Neurol Neurosurg Psychiatry. 2011 ; 82: 471-472
13. Fisher E, Lee J-C, Nakamura K, et al. Gray matter atrophy in multiple sclerosis: A longitudinal study. Ann Neurol. 2008 ; 64: 255-265
14. Fisniku LK, Chard DT, Jackson JS, et al. Gray matter atrophy is related to long-term disability in multiple sclerosis. Ann Neurol. 2008 ; 64: 247-254
15. Audoin B, Zaaraoui W, Reuter F, et al. Atrophy mainly affects the limbic system and the deep grey matter at the first stage of multiple sclerosis. J Neurol Neurosurg Psychiatry. 2010 ; 81: 690-695
16. Audoin B, Davies GR, Finisku L, et al. Localization of grey matter atrophy in early RRMS: A longitudinal study. J Neurol. 2006 ; 253: 1495-1501
17. Ceccarelli A, Rocca M, Pagani E, et al. A voxel-based morphometry study of grey matter loss in MS patients with different clinical phenotypes. Neuroimage. 2008 ; 42: 315-322
18. Schmierer K, Scaravilli F, Altmann DR, et al. Magnetization transfer ratio and myelin in postmortem multiple sclerosis brain. Ann Neurol. 2004 ; 56: 407-415
19. Chen J, Easley K, Schneider C, et al. Clinically feasible MTR is sensitive to cortical demyelination in MS. Neurology. 2013 ; 80: 246-252
20. Dehmeshki J, Chard DT, Leary SM, et al. The normal appearing grey matter in primary progressive multiple sclerosis: A magnetisation transfer imaging study. J Neurol. 2003 ; 250: 67-74
21. Ranjeva J-P, Audoin B, Au Duong M, et al. Local tissue damage assessed with statistical mapping analysis of brain magnetization transfer ratio: Relationship with functional status of patients in the earliest stage of multiple sclerosis. AJNR Am J Neuroradiol. 2005 ; 26: 119-27
22. Rovaris M, Filippi M.. MRI correlates of cognitive dysfunction in multiple sclerosis patients. J Neurovirol. 2000 ; 6: S172 - S175
23. Giuliani NR, Calhoun VD, Pearlson GD, et al. Voxel-based morphometry versus region of interest: A comparison of two methods for analyzing gray matter differences in schizophrenia. Schizophr Res. 2005 ; 74: 135-147
24. Audoin B, Ranjeva J-P, Au Duong M Van, et al. Voxel-based analysis of MTR images: A method to locate gray matter abnormalities in patients at the earliest stage of multiple sclerosis. J Magn Reson Imaging. 2004 ; 20: 765-771
25. Ashburner J, Friston KJ.. Voxel-based morphometry-The methods. Neuroimage. 2000 ; 11: 805-821
26. Audoin B, Davies G, Rashid W, et al. Voxel-based analysis of grey matter magnetization transfer ratio maps in early relapsing-remitting multiple sclerosis. Mult Scler. 2007 ; 13: 483-489
27. Khaleeli Z, Cercignani M, Audoin B, et al. Localized grey matter damage in early primary progressive multiple sclerosis contributes to disability. Neuroimage. 2007 ; 37: 253-261
28. Polman CH, Reingold SC, Banwell B, et al. Diagnostic criteria for multiple sclerosis: 2010 revisions to the McDonald criteria. Ann Neurol. 2011 ; 69: 292-302
29. NiftyregModat M. Available from: http://www0.cs.ucl.ac.uk/staff/M.Modat/Marcs-Page/Software.html (2010). [Accessed 27th August 2012].
30. Chard DT, Jackson JS, Miller DH, et al. Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes. J Magn Reson Imaging. 2010 ; 32: 223-228
31. Ashburner J.. A fast diffeomorphic image registration algorithm. Neuroimage. 2007 ; 38: 95-113
32. Jenkinson M, Beckmann CF, Behrens TEJ, et al. Fsl. Neuroimage. 2012 ; 62: 782-790
33. Casanova R, Srikanth R, Baer A, et al. Biological parametric mapping: A statistical toolbox for multimodality brain image analysis. Neuroimage. 2007 ; 34: 137-143
34. Rorden C, Karnath H-O, Bonilha L.. Improving lesion-symptom mapping. J Cogn Neurosci. 2007 ; 19: 1081-1088
35. Tzourio-Mazoyer N, Landeau B, Papathanassiou D, et al. Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage. 2002 ; 15: 273-289
36. Sepulcre J, Sastre-Garriga J, Cercignani M, et al. Regional gray matter atrophy in early primary progressive multiple sclerosis: A voxel-based morphometry study. Arch Neurol. 2006 ; 63: 1175-1180
37. Vercellino M, Plano F, Votta B, et al. Grey matter pathology in multiple sclerosis. J Neuropathol Exp Neurol. 2005 ; 64: 1101-1107
38. Bø L, Vedeler C, Nyland H, et al. Intracortical multiple sclerosis lesions are not associated with increased lymphocyte infiltration. Mult Scler. 2003 ; 9: 323-331
39. Brink BP, Veerhuis R, Breij ECW, et al. The pathology of multiple sclerosis is location-dependent: No significant complement activation is detected in purely cortical lesions. J Neuropathol Exp Neurol. 2005 ; 64: 147-155
40. Van Horssen J, Brink BP, de Vries HE, et al. The blood-brain barrier in cortical multiple sclerosis lesions. J Neuropathol Exp Neurol. 2007 ; 66: 321-328
41. Haider L, Simeonidou C, Steinberger G, et al. Multiple sclerosis deep grey matter: The relation between demyelination, neurodegeneration, inflammation and iron. J Neurol Neurosurg Psychiatry. :
42. Ceccarelli A, Jackson JS, Tauhid S, et al. The impact of lesion in-painting and registration methods on voxel-based morphometry in detecting regional cerebral gray matter atrophy in multiple sclerosis. AJNR Am J Neuroradiol. 2012 ; 33: 1579-1585