Towards host-directed therapies for tuberculosis

Nature Reviews Drug Discovery

Volumn 14, Issue 8, 2015, Pages 511-512

  Zumla, Alimuddin ^a,b   Maeurer, Markus ^c   Chakaya, Jeremiah ^d   Hoelscher, Michael ^e   Ntoumi, Francine ^f,g   Rustomjee, Roxana ^h   Vilaplana, Cristina ⁱ   Yeboah Manu, Dorothy ^j   Rasolofo, Voahangy ^k   Munderi, Paula ^l   Singh, Nalini ^m   Aklillu, Eleni ⁿ   Padayatchi, Nesri ^o   Macete, Eusebio ^p   Kapata, Nathan ^q   Mulenga, Modest ^r   Kibiki, Gibson ^s   Mfinanga, Sayoki ^t   Nyirenda, Thomas ^u   Maboko, Leonard ^v   Garcia Basteiro, Alberto ^p   Rakotosamimanana, Niaina ^k   Bates, Matthew ^q   Mwaba, Peter ^q   Reither, Klaus ^w   Gagneux, Sebastien ^w   Edwards, Sarah ^b   Mfinanga, Elirehema ^x   Abdulla, Salim ^x   Cardona, Pere Joan ⁱ   Russell, James B W ^y   Gant, Vanya ^b   Noursadeghi, Mahdad ^a,b   Elkington, Paul ^z   Bonnet, Maryline ^aa   Menendez, Clara ^ab,ac   Dieye, Tandakha N ^ad   Diarra, Bassirou ^ae   Maiga, Almoustapha ^ae   Aseffa, Abraham ^af   Parida, Shreemanta ^c   Wejse, Christian ^ag   Petersen, Eskild ^ag   Kaleebu, Pontiano ^l   Oliver, Matt ^ah   Craig, Gill ^ai   Corrah, Tumena ^aj   Tientcheu, Leopold ^ak   Antonio, Martin ^ak   Rao, Martin ^c   McHugh, Timothy D ^a,b   Sheikh, Aziz ^al   Ippolito, Giuseppe ^am   Ramjee, Gita ^h   Kaufmann, Stefan H E ^an   Churchyard, Gavin ^ao   Steyn, Andrie ^ap   Grobusch, Martin ^aq   Sanne, Ian ^ar   Martinson, Neil ^as   Madansein, Rajhmun ^at   Wilkinson, Robert J ^au,av   Mayosi, Bongani ^aw   Schito, Marco ^ax   Wallis, Robert S ^ao   more..

^a UNIVERSITY COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY COLLEGE LONDON HOSPITALS   (United Kingdom)

^c KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^d KENYA MEDICAL RESEARCH INSTITUTE   (Kenya)

^e UNIVERSITY OF MUNICH   (Germany)

^f Fondation Congolaise Pour la Recherche Medicale   (Congo)

^g UNIVERSITY OF TÜBINGEN   (Germany)

^h SOUTH AFRICAN MEDICAL RESEARCH COUNCIL   (South Africa)

ⁱ FUNDACIÓ INSTITUT D INVESTIGACIÓ EN CIÈNCIES DE LA SALUT GERMANS TRIAS I PUJOL   (Spain)

^j University of Ghana   (Ghana)

^k INSTITUT PASTEUR DE MADAGASCAR   (Madagascar)

^l UGANDA VIRUS RESEARCH INSTITUTE   (Uganda)

^m INKOSI ALBERT LUTHULI CENTRAL HOSPITAL   (South Africa)

ⁿ KAROLINSKA INSTITUTE   (Sweden)

^o UNIVERSITY OF KWAZULU NATAL   (South Africa)

^p Ministérioda Saúde   (Mozambique)

^q UNIVERSITY TEACHING HOSPITAL   (Zambia)

^r TROPICAL DISEASES RESEARCH CENTRE   (Zambia)

^s KILIMANJARO CLINICAL RESEARCH INSTITUTE   (Tanzania)

^t NATIONAL INSTITUTE OF MEDICAL RESEARCH   (Tanzania)

^u European Developing Countries Clinical Trials Partnership   (South Africa)

^v Mbeya Medical Research Centre   (Tanzania)

^w SWISS TROPICAL AND PUBLIC HEALTH INSTITUTE   (Switzerland)

^x IFAKARA HEALTH INSTITUTE   (Tanzania)

^y UNIVERSITY OF SIERRA LEONE   (Sierra Leone)

^z UNIVERSITY OF SOUTHAMPTON   (United Kingdom)

^aa EPICENTRE   (France)

^ab CENTRE FOR RESEARCH IN ENVIRONMENTAL EPIDEMIOLOGY CREAL   (Spain)

^ac Immunology Unit Laboratoire Bactériologie Virologie   (Senegal)

^ad Laboratories of the National Blood Transfusion Center   (Senegal)

^ae HIV TB Research and Training Center   (Mali)

^af ARMAUER HANSEN RESEARCH INSTITUTE   (Ethiopia)

^ag AARHUS UNIVERSITY   (Denmark)

^ah Resultancy   (United Kingdom)

^ai CITY UNIVERSITY   (United Kingdom)

^aj NORTHWICK PARK HOSPITAL   (United Kingdom)

^ak MEDICAL RESEARCH COUNCIL LABORATORIES   (Gambia)

^al UNIVERSITY OF EDINBURGH   (United Kingdom)

^am NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^an MAX PLANCK INSTITUTE   (Germany)

^ao AURUM INSTITUTE   (South Africa)

^ap UNIVERSITY OF KWAZULU NATAL   (South Africa)

^aq UNIVERSITY OF AMSTERDAM   (Netherlands)

^ar UNIVERSITY OF THE WITWATERSRAND   (South Africa)

^as Public Health Research Unit   (South Africa)

^at UNIVERSITY OF KWAZULU NATAL   (South Africa)

^au UNIVERSITY OF CAPE TOWN   (South Africa)

^av THE FRANCIS CRICK INSTITUTE   (United Kingdom)

^aw UNIVERSITY OF CAPE TOWN   (South Africa)

^ax CRITICAL PATH INSTITUTE   (United States)

more..

Author keywords

[No Author keywords available]

Indexed keywords

VITAMIN D; TUBERCULOSTATIC AGENT;

ANTIMICROBIAL THERAPY; BIOLOGICAL THERAPY; CELL THERAPY; CLINICAL EVALUATION; DRUG SENSITIVITY; HOST DIRECTED THERAPY; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOMODULATION; MESENCHYMAL STEM CELL TRANSPLANTATION; MIXED INFECTION; MULTIDRUG RESISTANT TUBERCULOSIS; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; PRIORITY JOURNAL; REVIEW; TUBERCULOSIS; DRUG COMBINATION; DRUG DESIGN; DRUG EFFECTS; MOLECULARLY TARGETED THERAPY;

ANTITUBERCULAR AGENTS; DRUG DESIGN; DRUG THERAPY, COMBINATION; HUMANS; MOLECULAR TARGETED THERAPY; MYCOBACTERIUM TUBERCULOSIS; TUBERCULOSIS;

EID: 84938418174     PISSN: 14741776     EISSN: 14741784     Source Type: Journal    
DOI: 10.1038/nrd4696     Document Type: Review

References (5)

1. Zumla, A., Nahid, P. & Cole, S. T. Advances in the development of new tuberculosis drugs and treatment regimens. Nat. Rev. Drug Discov. 12, 388-404 (2013).
2. Zumla, A. et al. Tuberculosis treatment and management - an update on treatment regimens, trials, new drugs, and adjunct therapies. Lancet Respir. Med. 3, 220-234 (2015).
3. Wallis, R. S.& Hafner, R. Advancing host-directed therapy for tuberculosis. Nat. Rev. Immunol.15, 255-263 (2015).
4. Bento, C. F., Empadinhas, N. & Mendes, V. Autophagy in the fight against tuberculosis. DNA Cell Biol. 34, 228-242 (2015).
5. Stanley, S. A. et al. Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth. PLoS Pathog. 10, e1003946 (2014