An Acoustic-Based Method to Detect and Quantify the Effect of Exhalation into a Dry Powder Inhaler

Journal of Aerosol Medicine and Pulmonary Drug Delivery

Volumn 28, Issue 4, 2015, Pages 247-253

  Holmes, Martin S ^a   Seheult, Jansen N ^b   O'Connell, Peter ^a   D'Arcy, Shona ^a   Ehrhardt, Carsten ^a   Healy, Anne Marie ^a   Costello, Richard W ^b   Reilly, Richard B ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

acoustics; diskus; dry powder inhalers; exhalation; humidity; signal processing

Indexed keywords

FLUTICASONE PROPIONATE; SALMETEROL XINAFOATE; AEROSOL; BRONCHODILATING AGENT; FLUTICASONE PROPIONATE PLUS SALMETEROL XINAFOATE; POWDER;

ACOUSTICS; AIR; ARTICLE; ASTHMA; CLINICAL ARTICLE; DRUG DELIVERY DEVICE; DRY POWDER INHALER; EXHALATION; FLOW RATE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMIDITY; IN VITRO STUDY; METHODOLOGY; PARTICLE SIZE; QUANTITATIVE ANALYSIS; RECORDING; SIGNAL PROCESSING; ABNORMAL RESPIRATORY SOUND; AEROSOL; ALGORITHM; CASE CONTROL STUDY; CHEMISTRY; DEVICES; DRUG DELIVERY SYSTEM; DRUG EFFECTS; EQUIPMENT DESIGN; INHALATION; INHALATIONAL DRUG ADMINISTRATION; LUNG; MULTIVARIATE ANALYSIS; PATHOPHYSIOLOGY; POWDER; REGRESSION ANALYSIS; SOUND DETECTION; TIME;

ACOUSTICS; ADMINISTRATION, INHALATION; AEROSOLS; AIR; ALGORITHMS; ASTHMA; BRONCHODILATOR AGENTS; CASE-CONTROL STUDIES; DRUG DELIVERY SYSTEMS; DRY POWDER INHALERS; EQUIPMENT DESIGN; EXHALATION; FLUTICASONE PROPIONATE, SALMETEROL XINAFOATE DRUG COMBINATION; HUMANS; HUMIDITY; INHALATION; LUNG; MULTIVARIATE ANALYSIS; POWDERS; REGRESSION ANALYSIS; RESPIRATORY SOUNDS; SIGNAL PROCESSING, COMPUTER-ASSISTED; SOUND SPECTROGRAPHY; TIME FACTORS;

EID: 84938373001     PISSN: 19412711     EISSN: 19412703     Source Type: Journal    
DOI: 10.1089/jamp.2014.1169     Document Type: Article

References (13)

1. Basheti IA, Bosnic-Anticevich SZ, Armour CL, and Reddel HK: Checklists for dry powder inhaler technique: A review and recommendations. Respir Care. 2014;59:1140-1154.
2. Basheti IA, Qunaibi E, Bosnic-Anticevich SZ, Armour CL, Khater S, Omar M, and Reddel HK: User error with Diskus and Turbuhaler by asthma patients and pharmacists in Jordan and Australia. Respir Care. 2011;56:1916-1923.
3. Melani AS, Bonavia M, Cilenti V, Cinti C, Lodi M, Martucci P, Serra M, Scichilone N, Sestini P, Aliani M, and Neri M: Inhaler mishandling remains common in real life and is associated with reduced disease control. Respir Med. 2011;105:930-938.
4. Lavorini F, Magnan A, Dubus JC, Voshaar T, Corbetta L, Broeders M, Dekhuijzen R, Sanchis J, Viejo JL, Barnes P, Corrigan C, Levy M, and Crompton GK: Effect of incorrect use of dry powder inhalers on management of patients with asthma and COPD. Respir Med. 2008;102:593-604.
5. Engel T, Scharling B, Skovsted B, and Heinig JH: Effects, side effects and plasma concentrations of terbutaline in adult asthmatics after inhaling from a dry powder inhaler device at different inhalation flows and volumes. Br J Clin Pharmacol. 1992;33:439-444.
6. Li H, Chen Y, Zhang Z, Dong X, Zhang G, and Zhang H: Handling of Diskus dry powder inhaler in Chinese chronic obstructive pulmonary disease patients. JAMP. 2014;27: 219-227.
7. D'Arcy S, MacHale E, Seheult J, Holmes MS, Hughes C, Sulaiman I, Hyland D, O'Reilly C, Glynn S, Al-Zaabi T, McCourt J, Taylor T, Keane F, Killane I, Reilly RB, and Costello RW: A method to assess adherence in inhaler use through analysis of acoustic recordings of inhaler events. PloS One. 2014;9:e98701.
8. Richardson JTE: Eta squared and partial eta squared as measures of effect size in educational research. Edu Res Rev. 2011;6:135-147.
9. Levine TR, and Hullett CR: Eta squared, partial eta squared, and misreporting of effect size in communication research. Human Commun Res. 2002;28:612-625.
10. Convention TUSP. Physical Tests and Determinations- Aerosols, Nasal Sprays, Metered-Dose Inhalers and Dry Powder Inhalers. USP. 2013;36:242-262.
11. Vitalograph. http://www.vitalograph.ie/. Accessed July 4, 2014.
12. Holmes MS, Seheult JN, Geraghty C, D'Arcy S, O'Brien U, Crispino O'Connell G, Costello RW, and Reilly RB: A method of estimating inspiratory flow rate and volume from an inhaler using acoustic measurements. Physiol Meas. 2013;34:903-914.
13. Paliwal KK: Decorrelated and liftered filter-bank energies for robust speech recognition. Eurospeech. 1999;99:85-88.