A method of estimating inspiratory flow rate and volume from an inhaler using acoustic measurements

Physiological Measurement

Volumn 34, Issue 8, 2013, Pages 903-914

  Holmes, Martin S ^a   Seheult, Jansen N ^b   Geraghty, Colm ^b   D'Arcy, Shona ^a   O'Brien, Ultan ^a   Crispino O'Connell, Gloria ^c   Costello, Richard W ^b   Reilly, Richard B ^a  

^a TRINITY COLLEGE DUBLIN   (Ireland)

^b ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

^c StatisticaMedica   (Ireland)

Author keywords

acoustics; asthma; COPD; inhalers; inspiratory flow rate; volume

Indexed keywords

ACOUSTIC VARIABLES MEASUREMENT; FLOW RATE; PULMONARY DISEASES;

ASTHMA; CHRONIC OBSTRUCTIVE PULMONARY DISEASE; CLINICAL OUTCOME; COPD; DRY POWDER INHALER; DRY POWDERS; INSPIRATORY FLOW; INSPIRATORY FLOW RATE; RELIABLE METHODS; VOLUME;

INTEGRATED CIRCUITS;

ACOUSTICS; ADOLESCENT; ADULT; ARTICLE; DEMOGRAPHY; EQUIPMENT; FLOW KINETICS; HUMAN; INHALATION; INSPIRATORY CAPACITY; NEBULIZER; PHYSIOLOGY; SPIROMETRY; YOUNG ADULT;

ACOUSTICS; ADOLESCENT; ADULT; DEMOGRAPHY; HUMANS; INHALATION; INSPIRATORY CAPACITY; NEBULIZERS AND VAPORIZERS; RHEOLOGY; SPIROMETRY; YOUNG ADULT;

EID: 84881488202     PISSN: 09673334     EISSN: 13616579     Source Type: Journal    
DOI: 10.1088/0967-3334/34/8/903     Document Type: Article

References (22)

1. Amirav I, Newhouse M T and Mansour Y 2005 Measurement of peak inspiratory flow with in-check dial device to simulate low-resistance (Diskus) and high-resistance (Turbohaler) dry powder inhalers in children with asthma Pediatr. Pulmonol. 39 447-51 (Pubitemid 40548287)
2. Braman S S 2006 The global burden of asthma Chest J. 130 4S-12S (Pubitemid 44107231)
3. British Standards Institution 2009 Anaesthetic and respiratory equipment. Peak expiratory flow meters for the assessment of pulmonary function in spontaneously breathing humans BS EN ISO 23747: 2009 (London: British Standards Institution)
4. Charbonneau G, Sudraud M and Soufflet G 1987 Method for the evaluation of flow rate from pulmonary sounds Bull. Eur. Physiopathol. Respir. 23 265-70 PMID: 3664016
5. Crompton G, Barnes P, Broeders M, Corrigan C, Corbetta L, Dekhuijzen R, Dubus J, Magnan A, Massone F and Sanchis J 2006 The need to improve inhalation technique in Europe: a report from the aerosol drug management improvement team Respir. Med. 100 1479-94 (Pubitemid 44109117)
6. Gavriely N and Cugell D W 1996 Airflow effects on amplitude and spectral content of normal breath sounds J. Appl. Physiol. 80 5-13 PMID: 8847331 (Pubitemid 26034839)
7. Hossain I and Moussavi Z 2004 Finding the lung sound-flow relationship in normal and asthmatic subjects IEEE 26th Annu. Int. Conf. on Engineering in Medicine and Biology Society pp 3852-5 (Pubitemid 40035498)
8. Janssens W, VandenBrande P, Hardeman E, De Langhe E, Philps T, Troosters T and Decramer M 2008 Inspiratory flow rates at different levels of resistance in elderly COPD patients Eur. Respir. J. 31 78-83
9. Jarvis S, Ind P W and Shiner R J 2007 Inhaled therapy in elderly COPD patients; time for re-evaluation? Age Ageing 36 213-8 (Pubitemid 46455403)
10. Kiyokawa H and Pasterkamp H 2002 Volume-dependent variations of regional lung sound, amplitude, and phase J. Appl. Physiol. 93 1030-8 PMID: 12183500 (Pubitemid 34919677)
11. Kraman S 1984 The relationship between airflow and lung sound amplitude in normal subjects Chest 86 225-9 (Pubitemid 14057151)
12. Magnussen H, Watz H, Zimmermann I, Macht S, Greguletz R, Falques M, Jarreta D and Garcia Gil E 2009 Peak inspiratory flow through the Genuair inhaler in patients with moderate or severe COPD Respir. Med. 103 1832-7
13. Malmberg L P, Rytilä P, Happonen P and Haahtela T 2010 Inspiratory flows through dry powder inhaler in chronic obstructive pulmonary disease: age and gender rather than severity matters Int. J. Chronic Obstruct. Pulm. Dis. 5 257
14. Mannino D M 2002 COPD epidemiology, prevalence, morbidity and mortality, and disease heterogeneity Chest J. 121 121S-6S
15. Miller M R, Hankinson J, Brusasco V, Burgos F, Casaburi R, Coates A, Crapo R, Enright P, Van Der Grinten C and Gustafsson P 2005 Standardisation of spirometry Eur. Respir. J. 26 319-38 (Pubitemid 41079078)
16. Nielsen K, Skov M, Klug B, Ifversen M and Bisgaard H 1997 Flow-dependent effect of formoterol dry-powder inhaled from the Aerolizer Eur. Respir. J. 10 2105-9 (Pubitemid 27406450)
17. Nikander K, Turpeinen M, Pelkonen A, Bengtsson T, Selroos O and Haahtela T 2011 True adherence with the Turbuhaler in young children with asthma Arch. Dis. Child. 96 168-73
18. Pauwels R, Newman S and Borgstrom L 1997 Airway deposition and airway effects of antiasthma drugs delivered from metered-dose inhalers Eur. Respir. J. 10 2127-38 (Pubitemid 27406455)
19. Shykoff B E, Ploysongsang Y and Chang H 1988 Airflow and normal lung sounds Am. J. Respir. Crit. Care Med. 137 872-6 (Pubitemid 18099301)
20. Sumby B, Cooper S and Smith I 1992 A comparison of the inspiratory effort required to operate the Diskhaler inhaler and Turbohaler inhaler in the administration of powder drug formulations Br. J. Clin. Res. 3 117-23
21. Vidgren M, Kärkkäinen A, Karjalainen P, Paronen P and Nuutinen J 1988 Effect of powder inhaler design on drug deposition in the respiratory tract Int. J. Pharm. 42 211-6 (Pubitemid 18092108)
22. Wieshammer S and Dreyhaupt J 2008 Dry powder inhalers: which factors determine the frequency of handling errors? Respiration 75 18-25