Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model

Pharmacological Research

Volumn 99, Issue , 2015, Pages 370-376

  Straiker, Alex ^a   Mitjavila, José ^a   Yin, Danielle ^a   Gibson, Anne ^a   Mackie, Ken ^a  

^a INDIANA UNIVERSITY   (United States)

Author keywords

Allosteric; Allosterism; Cannabinoid; Depolarization induced suppression of excitation; Excitatory postsynaptic current; Orthosteric; Tetrahydrocannabinol

Indexed keywords

4 (1,1 DIMETHYLHEPTYL) 1',2',3',4',5',6' HEXAHYDRO 2,3' DIHYDROXY 6' (3 HYDROXYPROPYL)BIPHENYL; CANNABINOID 1 RECEPTOR; CANNABINOID 1 RECEPTOR AGONIST; CANNABINOID 1 RECEPTOR ANTAGONIST; LIGAND; LIPOXIN A; PEPCAN12 PROTEIN; PREGNENOLONE; PROTEIN; PSNCBAM 1 PROTEIN; UNCLASSIFIED DRUG; 1-(4-CHLOROPHENYL)-3-(3-(6-PYRROLIDIN-1-YLPYRIDIN-2-YL)PHENYL)UREA; 5-CHLORO-3-ETHYL-1H-INDOLE-2-CARBOXYLIC ACID (2-(4-PIPERIDIN-1-YL-PHENYL)ETHYL)AMIDE; ACYLGLYCEROL; ARACHIDONIC ACID DERIVATIVE; CANNABINOID; CANNABINOID RECEPTOR AFFECTING AGENT; CARBANILAMIDE DERIVATIVE; ENDOCANNABINOID; GLYCERYL 2-ARACHIDONATE; INDOLE DERIVATIVE; PIPERIDINE DERIVATIVE; PYRIDINE DERIVATIVE;

ALLOSTERISM; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEPOLARIZATION; DRUG MECHANISM; EXCITATORY POSTSYNAPTIC POTENTIAL; HIPPOCAMPAL NEURONAL CULTURE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RECEPTOR BINDING; SYNAPTIC TRANSMISSION; ANIMAL; DRUG EFFECTS; HIPPOCAMPUS; METABOLISM; NERVE CELL; SIGNAL TRANSDUCTION;

ALLOSTERIC REGULATION; ANIMALS; ARACHIDONIC ACIDS; CANNABINOID RECEPTOR MODULATORS; CANNABINOIDS; ENDOCANNABINOIDS; EXCITATORY POSTSYNAPTIC POTENTIALS; GLYCERIDES; HIPPOCAMPUS; INDOLES; MICE; NEURONS; PHENYLUREA COMPOUNDS; PIPERIDINES; PYRIDINES; RECEPTOR, CANNABINOID, CB1; SIGNAL TRANSDUCTION; SYNAPTIC TRANSMISSION;

EID: 84938361168     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2015.07.017     Document Type: Article

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