The Regulatory Factor ZFHX3 Modifies Circadian Function in SCN via an at Motif-Driven Axis

Cell

Volumn 162, Issue 3, 2015, Pages 607-621

  Parsons, Michael J ^a   Brancaccio, Marco ^b   Sethi, Siddharth ^a   Maywood, Elizabeth S ^b   Satija, Rahul ^c,d   Edwards, Jessica K ^a   Jagannath, Aarti ^e   Couch, Yvonne ^e   Finelli, Mattéa J ^e   Smyllie, Nicola J ^b   Esapa, Christopher ^a   Butler, Rachel ^e   Barnard, Alun R ^e   Chesham, Johanna E ^b   Saito, Shoko ^f,g   Joynson, Greg ^a   Wells, Sara ^a   Foster, Russell G ^e   Oliver, Peter L ^e   Simon, Michelle M ^a   Mallon, Ann Marie ^a   Hastings, Michael H ^b   Nolan, Patrick M ^a   more..

^a MRC MAMMALIAN GENETICS UNIT   (United Kingdom)

^b MRC LABORATORY OF MOLECULAR BIOLOGY   (United Kingdom)

^c NEW YORK GENOME CENTER   (United States)

^d NEW YORK UNIVERSITY   (United States)

^e UNIVERSITY OF OXFORD   (United Kingdom)

^f ERASMUS MEDICAL CENTER   (Netherlands)

^g UNIVERSITY OF TSUKUBA   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ARGIPRESSIN; GASTRIN RELEASING PEPTIDE; HOMEODOMAIN PROTEIN; NEUROPEPTIDE; PROKINETICIN 2; SMALL INTERFERING RNA; UNCLASSIFIED DRUG; ZINC FINGER HOMEOBOX 3 PROTEIN; ZFHX3 PROTEIN, MOUSE;

ADULT; ANIMAL TISSUE; ARTICLE; BIOLUMINESCENCE; CELL LYSATE; CHROMOSOME 8; CIRCADIAN RHYTHM; COMPARATIVE STUDY; CONTROLLED STUDY; DOWN REGULATION; EX VIVO STUDY; GENE EXPRESSION; GENETIC TRANSFECTION; GENOTYPE; HEK293 CELL LINE; HEREDITY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; IN VITRO STUDY; LIGHT DARK CYCLE; LOCOMOTION; MISSENSE MUTATION; MOUSE; NONHUMAN; OSCILLATION; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN EXPRESSION; RNA SEQUENCE; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION INITIATION; TRANSCRIPTION INITIATION SITE; ZINC FINGER MOTIF; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; GENETICS; METABOLISM; MOLECULAR GENETICS; MUTATION; NUCLEOTIDE MOTIF; SEQUENCE ALIGNMENT;

MUS;

AMINO ACID SEQUENCE; ANIMALS; CIRCADIAN RHYTHM; DOWN-REGULATION; GENE EXPRESSION REGULATION; HOMEODOMAIN PROTEINS; IN VITRO TECHNIQUES; MICE; MICE, INBRED C57BL; MOLECULAR SEQUENCE DATA; MUTATION; NEUROPEPTIDES; NUCLEOTIDE MOTIFS; PROMOTER REGIONS, GENETIC; SEQUENCE ALIGNMENT; SUPRACHIASMATIC NUCLEUS; TRANSCRIPTION, GENETIC;

EID: 84938241496     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.06.060     Document Type: Article

References (48)

1. A. Acevedo-Arozena, S. Wells, P. Potter, M. Kelly, R.D. Cox, and S.D. Brown ENU mutagenesis, a way forward to understand gene function Annu. Rev. Genomics Hum. Genet. 9 2008 49 69
2. H.E. Albers, C.F. Gillespie, T.O. Babagbemi, and K.L. Huhman Analysis of the phase shifting effects of gastrin releasing peptide when microinjected into the suprachiasmatic region Neurosci. Lett. 191 1995 63 66
3. U. Albrecht Timing to perfection: the biology of central and peripheral circadian clocks Neuron 74 2012 246 260
4. S. An, R. Harang, K. Meeker, D. Granados-Fuentes, C.A. Tsai, C. Mazuski, J. Kim, F.J. Doyle III, L.R. Petzold, and E.D. Herzog A neuropeptide speeds circadian entrainment by reducing intercellular synchrony Proc. Natl. Acad. Sci. USA 110 2013 E4355 E4361
5. S.J. Aton, and E.D. Herzog Come together, right. now: synchronization of rhythms in a mammalian circadian clock Neuron 48 2005 531 534
6. S.J. Aton, C.S. Colwell, A.J. Harmar, J. Waschek, and E.D. Herzog Vasoactive intestinal polypeptide mediates circadian rhythmicity and synchrony in mammalian clock neurons Nat. Neurosci. 8 2005 476 483
7. Y. Bacon, A. Ooi, S. Kerr, L. Shaw-Andrews, L. Winchester, S. Breeds, Z. Tymoska-Lalanne, J. Clay, A.G. Greenfield, and P.M. Nolan Screening for novel ENU-induced rhythm, entrainment and activity mutants Genes Brain Behav. 3 2004 196 205
8. G.D. Bader, and C.W. Hogue An automated method for finding molecular complexes in large protein interaction networks BMC Bioinformatics 4 2003 2
9. T.L. Bailey, and C. Elkan Fitting a mixture model by expectation maximization to discover motifs in biopolymers Proc. Int. Conf. Intell. Syst. Mol. Biol. 2 1994 28 36
10. J.L. Bedont, T.A. LeGates, E.A. Slat, M.S. Byerly, H. Wang, J. Hu, A.C. Rupp, J. Qian, G.W. Wong, E.D. Herzog, and et al. Lhx1 controls terminal differentiation and circadian function of the suprachiasmatic nucleus Cell Rep. 7 2014 609 622
11. F.B. Berry, Y. Miura, K. Mihara, P. Kaspar, N. Sakata, T. Hashimoto-Tamaoki, and T. Tamaoki Positive and negative regulation of myogenic differentiation of C2C12 cells by isoforms of the multiple homeodomain zinc finger transcription factor ATBF1 J. Biol. Chem. 276 2001 25057 25065
12. K. Bozek, A. Relógio, S.M. Kielbasa, M. Heine, C. Dame, A. Kramer, and H. Herzel Regulation of clock-controlled genes in mammals PLoS ONE 4 2009 e4882
13. K. Bozek, A.L. Rosahl, S. Gaub, S. Lorenzen, and H. Herzel Circadian transcription in liver Biosystems 102 2010 61 69
14. M. Brancaccio, E.S. Maywood, J.E. Chesham, A.S. Loudon, and M.H. Hastings A Gq-Ca2+ axis controls circuit-level encoding of circadian time in the suprachiasmatic nucleus Neuron 78 2013 714 728
15. T.M. Brown, A.T. Hughes, and H.D. Piggins Gastrin-releasing peptide promotes suprachiasmatic nuclei cellular rhythmicity in the absence of vasoactive intestinal polypeptide-VPAC2 receptor signaling J. Neurosci. 25 2005 11155 11164
16. T.M. Brown, C.S. Colwell, J.A. Waschek, and H.D. Piggins Disrupted neuronal activity rhythms in the suprachiasmatic nuclei of vasoactive intestinal polypeptide-deficient mice J. Neurophysiol. 97 2007 2553 2558
17. J.P. DeBruyne, E. Noton, C.M. Lambert, E.S. Maywood, D.R. Weaver, and S.M. Reppert A clock shock: mouse CLOCK is not required for circadian oscillator function Neuron 50 2006 465 477
18. D. Feng, T. Liu, Z. Sun, A. Bugge, S.E. Mullican, T. Alenghat, X.S. Liu, and M.A. Lazar A circadian rhythm orchestrated by histone deacetylase 3 controls hepatic lipid metabolism Science 331 2011 1315 1319
19. S.I. Godinho, E.S. Maywood, L. Shaw, V. Tucci, A.R. Barnard, L. Busino, M. Pagano, R. Kendall, M.M. Quwailid, M.R. Romero, and et al. The after-hours mutant reveals a role for Fbxl3 in determining mammalian circadian period Science 316 2007 897 900
20. D.A. Gold, P.M. Gent, and B.A. Hamilton ROR alpha in genetic control of cerebellum development: 50 staggering years Brain Res. 1140 2007 19 25
21. M. Hatori, S. Gill, L.S. Mure, M. Goulding, D.D. O'Leary, and S. Panda Lhx1 maintains synchrony among circadian oscillator neurons of the SCN eLife 3 2014 e03357
22. Y. Ishii, M. Kawaguchi, K. Takagawa, T. Oya, S. Nogami, A. Tamura, Y. Miura, A. Ido, N. Sakata, T. Hashimoto-Tamaoki, and et al. ATBF1-A protein, but not ATBF1-B, is preferentially expressed in developing rat brain J. Comp. Neurol. 465 2003 57 71
23. N. Koike, S.H. Yoo, H.C. Huang, V. Kumar, C. Lee, T.K. Kim, and J.S. Takahashi Transcriptional architecture and chromatin landscape of the core circadian clock in mammals Science 338 2012 349 354
24. R.J. Konopka, and S. Benzer Clock mutants of Drosophila melanogaster Proc. Natl. Acad. Sci. USA 68 1971 2112 2116
25. C. Lee, J.P. Etchegaray, F.R. Cagampang, A.S. Loudon, and S.M. Reppert Posttranslational mechanisms regulate the mammalian circadian clock Cell 107 2001 855 867
26. I.T. Lee, A.S. Chang, M. Manandhar, Y. Shan, J. Fan, M. Izumo, Y. Ikeda, T. Motoike, S. Dixon, J.E. Seinfeld, and et al. Neuromedin s-producing neurons act as essential pacemakers in the suprachiasmatic nucleus to couple clock neurons and dictate circadian rhythms Neuron 85 2015 1086 1102
27. E.S. Lein, M.J. Hawrylycz, N. Ao, M. Ayres, A. Bensinger, A. Bernard, A.F. Boe, M.S. Boguski, K.S. Brockway, E.J. Byrnes, and et al. Genome-wide atlas of gene expression in the adult mouse brain Nature 445 2007 168 176
28. J.D. Li, W.P. Hu, L. Boehmer, M.Y. Cheng, A.G. Lee, A. Jilek, J.M. Siegel, and Q.Y. Zhou Attenuated circadian rhythms in mice lacking the prokineticin 2 gene J. Neurosci. 26 2006 11615 11623
29. A.C. Liu, D.K. Welsh, C.H. Ko, H.G. Tran, E.E. Zhang, A.A. Priest, E.D. Buhr, O. Singer, K. Meeker, I.M. Verma, and et al. Intercellular coupling confers robustness against mutations in the SCN circadian clock network Cell 129 2007 605 616
30. E.S. Maywood, A.B. Reddy, G.K. Wong, J.S. O'Neill, J.A. O'Brien, D.G. McMahon, A.J. Harmar, H. Okamura, and M.H. Hastings Synchronization and maintenance of timekeeping in suprachiasmatic circadian clock cells by neuropeptidergic signaling Curr. Biol. 16 2006 599 605
31. E.S. Maywood, J.E. Chesham, J.A. O'Brien, and M.H. Hastings A diversity of paracrine signals sustains molecular circadian cycling in suprachiasmatic nucleus circuits Proc. Natl. Acad. Sci. USA 108 2011 14306 14311
32. E.S. Maywood, L. Drynan, J.E. Chesham, M.D. Edwards, H. Dardente, J.M. Fustin, D.G. Hazlerigg, J.S. O'Neill, G.F. Codner, N.J. Smyllie, and et al. Analysis of core circadian feedback loop in suprachiasmatic nucleus of mCry1-luc transgenic reporter mouse Proc. Natl. Acad. Sci. USA 110 2013 9547 9552
33. Q.J. Meng, E.S. Maywood, D.A. Bechtold, W.Q. Lu, J. Li, J.E. Gibbs, S.M. Dupré, J.E. Chesham, F. Rajamohan, J. Knafels, and et al. Entrainment of disrupted circadian behavior through inhibition of casein kinase 1 (CK1) enzymes Proc. Natl. Acad. Sci. USA 107 2010 15240 15245
34. Y. Mori, H. Kataoka, Y. Miura, M. Kawaguchi, E. Kubota, N. Ogasawara, T. Oshima, S. Tanida, M. Sasaki, H. Ohara, and et al. Subcellular localization of ATBF1 regulates MUC5AC transcription in gastric cancer Int. J. Cancer 121 2007 241 247
35. H.M. Prosser, A. Bradley, J.E. Chesham, F.J. Ebling, M.H. Hastings, and E.S. Maywood Prokineticin receptor 2 (Prokr2) is essential for the regulation of circadian behavior by the suprachiasmatic nuclei Proc. Natl. Acad. Sci. USA 104 2007 648 653
36. Y. Qi, J.A. Ranish, X. Zhu, A. Krones, J. Zhang, R. Aebersold, D.W. Rose, M.G. Rosenfeld, and C. Carrière Atbf1 is required for the Pit1 gene early activation Proc. Natl. Acad. Sci. USA 105 2008 2481 2486
37. M.R. Ralph, R.G. Foster, F.C. Davis, and M. Menaker Transplanted suprachiasmatic nucleus determines circadian period Science 247 1990 975 978
38. N. Sakata, S. Kaneko, S. Ikeno, Y. Miura, H. Nakabayashi, X.Y. Dong, J.T. Dong, T. Tamaoki, N. Nakano, and S. Itoh TGF-β signaling cooperates with AT motif-binding factor-1 for repression of the α-fetoprotein promoter J. Signal Transduct. 2014 2014 970346
39. K. Shinohara, K. Tominaga, Y. Isobe, and S.T. Inouye Photic regulation of peptides located in the ventrolateral subdivision of the suprachiasmatic nucleus of the rat: daily variations of vasoactive intestinal polypeptide, gastrin-releasing peptide, and neuropeptide Y J. Neurosci. 13 1993 793 800
40. X. Sun, X. Fu, J. Li, C. Xing, D.W. Martin, H.H. Zhang, Z. Chen, and J.T. Dong Heterozygous deletion of Atbf1 by the Cre-loxP system in mice causes preweaning mortality Genesis 50 2012 819 827
41. H. Ukai, and H.R. Ueda Systems biology of mammalian circadian clocks Annu. Rev. Physiol. 72 2010 579 603
42. C. VanDunk, L.A. Hunter, and P.A. Gray Development, maturation, and necessity of transcription factors in the mouse suprachiasmatic nucleus J. Neurosci. 31 2011 6457 6467
43. M.H. Vitaterna, D.P. King, A.M. Chang, J.M. Kornhauser, P.L. Lowrey, J.D. McDonald, W.F. Dove, L.H. Pinto, F.W. Turek, and J.S. Takahashi Mutagenesis and mapping of a mouse gene, Clock, essential for circadian behavior Science 264 1994 719 725
44. Y. Yamaguchi, T. Suzuki, Y. Mizoro, H. Kori, K. Okada, Y. Chen, J.M. Fustin, F. Yamazaki, N. Mizuguchi, J. Zhang, and et al. Mice genetically deficient in vasopressin V1a and V1b receptors are resistant to jet lag Science 342 2013 85 90
45. H. Yasuda, A. Mizuno, T. Tamaoki, and T. Morinaga ATBF1, a multiple-homeodomain zinc finger protein, selectively down-regulates AT-rich elements of the human alpha-fetoprotein gene Mol. Cell. Biol. 14 1994 1395 1401
46. F. Zambelli, G. Pesole, and G. Pavesi Pscan: finding over-represented transcription factor binding site motifs in sequences from co-regulated or co-expressed genes Nucleic Acids Res. 37 2009 W247 W252
47. E.E. Zhang, and S.A. Kay Clocks not winding down: unravelling circadian networks Nat. Rev. Mol. Cell Biol. 11 2010 764 776
48. E.E. Zhang, A.C. Liu, T. Hirota, L.J. Miraglia, G. Welch, P.Y. Pongsawakul, X. Liu, A. Atwood, J.W. Huss III, J. Janes, and et al. A genome-wide RNAi screen for modifiers of the circadian clock in human cells Cell 139 2009 199 210