Outpatient overnight glucose control with dual-hormone artificial pancreas, single-hormone artificial pancreas, or conventional insulin pump therapy in children and adolescents with type 1 diabetes: An open-label, randomised controlled trial

The Lancet Diabetes and Endocrinology

Volumn 3, Issue 8, 2015, Pages 595-604

  Haidar, Ahmad ^a,b   Legault, Laurent ^c   Matteau Pelletier, Laurence ^a   Messier, Virginie ^a   Dallaire, Maryse ^a   Ladouceur, Martin ^d   Rabasa Lhoret, Rémi ^a,b,e,f  

^a CLIN RESEARCH INSTITUTE OF MONTREAL   (Canada)

^b MCGILL UNIVERSITY   (Canada)

^c MONTREAL CHILDREN S HOSPITAL   (Canada)

^d CENTRE HOSPITALIER DE L UNIVERSITÉ DE MONTRÉAL   (Canada)

^e UNIVERSITÉ DE MONTRÉAL   (Canada)

^f Montreal Diabetes Research Center   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLUCAGON; GLUCOSE; INSULIN ASPART; GLUCOSE BLOOD LEVEL; INSULIN;

ADOLESCENT; AREA UNDER THE CURVE; ARTICLE; ARTIFICIAL PANCREAS; BLOOD GLUCOSE MONITORING; CANADA; CARBOHYDRATE INTAKE; CHILD; CLINICAL ARTICLE; CLINICAL EFFECTIVENESS; COMPARATIVE EFFECTIVENESS; CONTINUOUS INFUSION; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIABETES CONTROL; DUAL HORMONE ARTIFICIAL PANCREAS; HUMAN; HYPERGLYCEMIA; INSULIN DEPENDENT DIABETES MELLITUS; INSULIN PUMP; INTENTION TO TREAT ANALYSIS; NOCTURNAL HYPOGLYCEMIA; OUTCOME ASSESSMENT; OUTPATIENT CARE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SCHOOL CHILD; SINGLE HORMONE ARTIFICIAL PANCREAS; TREATMENT DURATION; BLOOD; CLINICAL TRIAL; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCOSE BLOOD LEVEL; IMPLANTABLE INFUSION PUMP; INSULIN INFUSION; MALE; OUTPATIENT; TREATMENT OUTCOME;

ADOLESCENT; BLOOD GLUCOSE; CANADA; CHILD; CROSS-OVER STUDIES; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCAGON; HUMANS; INFUSION PUMPS, IMPLANTABLE; INSULIN; INSULIN INFUSION SYSTEMS; MALE; OUTPATIENTS; PANCREAS, ARTIFICIAL; TREATMENT OUTCOME;

EID: 84938203857     PISSN: 22138587     EISSN: 22138595     Source Type: Journal    
DOI: 10.1016/S2213-8587(15)00141-2     Document Type: Article

References (23)

1. Maahs DM, West NA, Lawrence JM, et al. Epidemiology of type 1 diabetes. Endocrinol Metab Clin North Am 2010, 39:481-497.
2. White NH, Cleary PA, Dahms W, et al. Beneficial effects of intensive therapy of diabetes during adolescence: outcomes after the conclusion of the Diabetes Control and Complications Trial (DCCT). J Pediatr 2001, 139:804-812.
3. Mortensen HB Findings from the Hvidore Study Group on Childhood Diabetes: metabolic control and quality of life. Horm Res 2002, 57(suppl 1):117-120.
4. Wood JR, Miller KM, Maahs DM, et al. Most youth with type 1 diabetes in the T1D Exchange Clinic Registry do not meet American Diabetes Association or International Society for Pediatric and Adolescent Diabetes clinical guidelines. Diabetes Care 2013, 36:2035-2037.
5. Davis EA, Keating B, Byrne GC, et al. Hypoglycemia: incidence and clinical predictors in a large population-based sample of children and adolescents with IDDM. Diabetes Care 1997, 20:22-25.
6. Prolonged nocturnal hypoglycemia is common during 12 months of continuous glucose monitoring in children and adults with type 1 diabetes. Diabetes Care 2010, 33:1004-1008.
7. Monaghan MC, Hilliard ME, Cogen FR, et al. Nighttime caregiving behaviors among parents of young children with Type 1 diabetes: associations with illness characteristics and parent functioning. Fam Syst Health 2009, 27:28-38.
8. Tamborlane WV, Beck RW, Bode BW, et al. Continuous glucose monitoring and intensive treatment of type 1 diabetes. N Engl J Med 2008, 359:1464-1476.
9. Bergenstal RM, Tamborlane WV, Ahmann A, et al. Effectiveness of sensor-augmented insulin-pump therapy in type 1 diabetes. N Engl J Med 2010, 363:311-320.
10. Ly TT, Nicholas JA, Retterath A, et al. Effect of sensor-augmented insulin pump therapy and automated insulin suspension vs standard insulin pump therapy on hypoglycemia in patients with type 1 diabetes: a randomized clinical trial. JAMA 2013, 310:1240-1247.
11. Hovorka R Closed-loop insulin delivery: from bench to clinical practice. Nat Rev Endocrinol 2011, 7:385-395.
12. Hovorka R, Elleri D, Thabit H, et al. Overnight closed-loop insulin delivery in young people with type 1 diabetes: a free-living, randomized clinical trial. Diabetes Care 2014, 37:1204-1211.
13. Nimri R, Muller I, Atlas E, et al. MD-Logic overnight control for 6 weeks of home use in patients with type 1 diabetes: randomized crossover trial. Diabetes Care 2014, 37:3025-3032.
14. Phillip M, Battelino T, Atlas E, et al. Nocturnal glucose control with an artificial pancreas at a diabetes camp. N Engl J Med 2013, 368:824-833.
15. Ly TT, Breton MD, Keith-Hynes P, et al. Overnight glucose control with an automated, unified safety system in children and adolescents with type 1 diabetes at diabetes cAMP. Diabetes Care 2014, 37:2310-2316.
16. Castle JR, Engle JM, El Youssef J, et al. Novel use of glucagon in a closed-loop system for prevention of hypoglycemia in type 1 diabetes. Diabetes Care 2010, 33:1282-1287.
17. Haidar A, Legault L, Dallaire M, et al. Glucose-responsive insulin and glucagon delivery (dual-hormone artificial pancreas) in adults with type 1 diabetes: a randomized crossover controlled trial. CMAJ 2013, 185:297-305.
18. Russell SJ, El-Khatib FH, Sinha M, et al. Outpatient glycemic control with a bionic pancreas in type 1 diabetes. N Engl J Med 2014, 371:313-325.
19. Haidar A, Legault L, Messier V, et al. Comparison of dual-hormone artificial pancreas, single-hormone artificial pancreas, and conventional insulin pump therapy for glycaemic control in patients with type 1 diabetes: an open-label randomised controlled crossover trial. Lancet Diabetes Endocrinol 2015, 1:17-26.
20. Desjardins K, Brazeau AS, Strychar I, et al. Association between post-dinner dietary intakes and nocturnal hypoglycemic risk in adult patients with type 1 diabetes. Diabetes Res Clin Pract 2014, 106:420-427.
21. Kalra S, Gupta Y Ultra-fast acting insulin analogues. Recent Pat Endocr Metab Immune Drug Discov 2014, 8:117-123.
22. Nimri R, Muller I, Atlas E, et al. Night glucose control with MD-Logic artificial pancreas in home setting: a single blind, randomized crossover trial-interim analysis. Pediatr Diabetes 2014, 15:91-99.
23. Thabit H, Lubina-Solomon A, Stadler M, et al. Home use of closed-loop insulin delivery for overnight glucose control in adults with type 1 diabetes: a 4-week, multicentre, randomised crossover study. Lancet Diabetes Endocrinol 2014, 2:701-709.