Microlocalization of CD68+ tumor-associated macrophages in tumor stroma correlated with poor clinical outcomes in oral squamous cell carcinoma patients

Tumor Biology

Volumn 36, Issue 7, 2015, Pages 5291-5298

  Ni, Yan Hong ^a   Ding, Liang ^a   Huang, Xiao Feng ^b   Dong, Ying chun ^b   Hu, Qin Gang ^b   Hou, Ya Yi ^a  

^a NANJING UNIVERSITY   (China)

^b MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

CD68; Microlocalization; Oral squamous cell carcinoma; Prognosis; Tumor associated macrophages

Indexed keywords

CD68 ANTIGEN; CD68 ANTIGEN, HUMAN; DIFFERENTIATION ANTIGEN; LEUKOCYTE ANTIGEN; TUMOR MARKER;

ADULT; ANTIGEN EXPRESSION; ARTICLE; CANCER GRADING; CANCER GROWTH; CANCER PATIENT; CANCER PROGNOSIS; CANCER TISSUE; CARCINOGENESIS; CELL COUNT; CELL INFILTRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE FREE SURVIVAL; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; LYMPHOCYTE; MAJOR CLINICAL STUDY; MALE; MONOCYTE; MOUTH SQUAMOUS CELL CARCINOMA; OVERALL SURVIVAL; PRIORITY JOURNAL; RETROSPECTIVE STUDY; STROMA; SURVIVAL TIME; TUMOR ASSOCIATED LEUKOCYTE; TUMOR STROMA; AGED; BLOOD; MACROPHAGE; MIDDLE AGED; MOUTH TUMOR; PATHOLOGY; PROGNOSIS; PROPORTIONAL HAZARDS MODEL; SQUAMOUS CELL CARCINOMA; STROMA CELL; TREATMENT OUTCOME;

ADULT; AGED; ANTIGENS, CD; ANTIGENS, DIFFERENTIATION, MYELOMONOCYTIC; CARCINOMA, SQUAMOUS CELL; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; LYMPHATIC METASTASIS; MACROPHAGES; MALE; MIDDLE AGED; MOUTH NEOPLASMS; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; STROMAL CELLS; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 84938199238     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-015-3189-5     Document Type: Article

References (26)

1. Rao SK, Pavicevic Z, Du ZY, Kim JG, Fan MY, Jiao Y, et al. Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. J Biol Chem. 2010;285(42):32512–21. doi:10.1074/jbc.M110.150490.
2. Shi C, Pamer EG. Monocyte recruitment during infection and inflammation. Nat Rev Immunol. 2011;11(11):762–74. doi:10.1038/Nri3070.
3. Taylor PR, Martinez-Pomares L, Stacey M, Lin HH, Brown GD, Gordon S. Macrophage receptors and immune recognition. Annu Rev Immunol. 2005;23:901–44. doi:10.1146/annurev.immunol.23.021704.115816.
4. Ruffell B, Au A, Rugo HS, Esserman LJ, Hwang ES, Coussens LM. Leukocyte composition of human breast cancer. Proc Natl Acad Sci U S A. 2012;109(8):2796–801. doi:10.1073/pnas.1104303108.
5. Sica A, Schioppa T, Mantovani A, Allavena P. Tumour-associated macrophages are a distinct M2 polarised population promoting tumour progression: Potential targets of anti-cancer therapy. Eur J Cancer. 2006;42(6):717–27. doi:10.1016/j.ejca.2006.01.003.
6. Gottfried E, Kunz-Schughart LA, Weber A, Rehli M, Peuker A, Muller A, et al. Expression of CD68 in non-myeloid cell types. Scand J Immunol. 2008;67(5):453–63. doi:10.1111/j.1365-3083.2008.02091.x.
7. Chen JJW, Lin YC, Yao PL, Yuan A, Chen HY, Shun CT, et al. Tumor-associated macrophages: the double-edged sword in cancer progression. J Clin Oncol. 2005;23(5):953–64. doi:10.1200/Jco.2005.12.172. 23.
8. Koide N, Nishio A, Sato T, Sugiyama A, Miyagawa S. Significance of macrophage chemoattractant protein-1 expression and macrophage infiltration in squamous cell carcinoma of the esophagus. Am J Gastroenterol. 2004;99(9):1667–74. doi:10.1111/j.1572-0241.2004.30733.x.
9. Ryder M, Ghossein RA, Ricarte JCM, Knauf JA, Fagin JA. Increased density of tumor-associated macrophages is associated with decreased survival in advanced thyroid cancer. Endoc-Relat Cancer. 2008;15(4):1069–74. doi:10.1677/Erc-08-0036.
10. Zhu XD, Zhang JB, Zhuang PY, Zhu HG, Zhang W, Xiong YQ, et al. High expression of macrophage colony-stimulating factor in peritumoral liver tissue is associated with poor survival after curative resection of hepatocellular carcinoma. J Clin Oncol. 2008;26(16):2707–16. doi:10.1200/Jco.2007.15.6521.
11. Costa NL, Valadares MC, Souza PP, Mendonca EF, Oliveira JC, Silva TA, et al. Tumor-associated macrophages and the profile of inflammatory cytokines in oral squamous cell carcinoma. Oral Oncol. 2013;49(3):216–23. doi:10.1016/j.oraloncology.2012.09.012.
12. He KF, Zhang L, Huang CF, Ma SR, Wang YF, Wang WM, et al. CD163+ tumor-associated macrophages correlated with poor prognosis and cancer stem cells in oral squamous cell carcinoma. Bio Med Research Int. 2014;2014:838632. doi:10.1155/2014/838632.
13. Boas DS, Takiya CM, Gurgel CA, Cabral MG, Santos JN. Tumor-infiltrating macrophage and microvessel density in oral squamous cell carcinoma. Braz Dent J. 2013;24(3):194–9. doi:10.1590/0103-6440201302049.
14. Cook J, Hagemann T. Tumour-associated macrophages and cancer. Curr Opin Pharmacol. 2013;13(4):595–601. doi:10.1016/j.coph.2013.05.017.
15. Zhou J, Ding T, Pan WD, Zhu LY, Li L, Zheng LM. Increased intratumoral regulatory T cells are related to intratumoral macrophages and poor prognosis in hepatocellular carcinoma patients. Int J Cancer. 2009;125(7):1640–8. doi:10.1002/Ijc.24556.
16. Medrek C, Ponten F, Jirstrom K, Leandersson K. The presence of tumor associated macrophages in tumor stroma as a prognostic marker for breast cancer patients. BMC Cancer. 2012;12:306. doi:10.1186/1471-2407-12-306.
17. Sandel MH, Dadabayev AR, Menon AG, Morreau H, Melief CJ, Offringa R, et al. Prognostic value of tumor-infiltrating dendritic cells in colorectal cancer: role of maturation status and intratumoral localization. Clin Cancer Res Off J Am Assoc Cancer Res. 2005;11(7):2576–82. doi:10.1158/1078-0432.CCR-04-1448.
18. Jemal A, Siegel R, Ward E, Murray T, Xu JQ, Smigal C, et al. Cancer statistics, 2006. CA Cancer J Clin. 2006;56(2):106–30.
19. Boas DSV, Takiya CM, Coelho-Sampaio TL, Moncao-Ribeiro LC, Ramos EAG, Cabral MG, et al. Immunohistochemical detection of Ki-67 is not associated with tumor-infiltrating macrophages and cyclooxygenase-2 in oral squamous cell carcinoma. J Oral Pathol Med. 2010;39(7):565–70. doi:10.1111/j.1600-0714.2010.00883.x.
20. El-Rouby DH. Association of macrophages with angiogenesis in oral verrucous and squamous cell carcinomas. J Oral Pathol Med. 2010;39(7):559–64. doi:10.1111/j.1600-0714.2010.00879.x.
21. Fujii N, Shomori K, Shiomi T, Nakabayashi M, Takeda C, Ryoke K, et al. Cancer-associated fibroblasts and CD163-positive macrophages in oral squamous cell carcinoma: their clinicopathological and prognostic significance. J Oral Pathol Med. 2012;41(6):444–51. doi:10.1111/j.1600-0714.2012.01127.x.
22. Liu SY, Chang LC, Pan LF, Hung YJ, Lee CH, Shieh YS. Clinicopathologic significance of tumor cell-lined vessel and microenvironment in oral squamous cell carcinoma. Oral Oncol. 2008;44(3):277–85. doi:10.1016/j.oraloncology.2007.02.007.
23. Gollapudi K, Galet C, Grogan T, Zhang H, Said JW, Huang J, et al. Association between tumor-associated macrophage infiltration, high grade prostate cancer, and biochemical recurrence after radical prostatectomy. Am J Cancer Res. 2013;3(5):523–9.
24. Mahmoud SMA, Lee AHS, Paish EC, Macmillan RD, Ellis IO, Green AR. Tumour-infiltrating macrophages and clinical outcome in breast cancer. J Clin Pathol. 2012;65(2):159–63. doi:10.1136/jclinpath-2011-200355.
25. Pantano F, Berti P, Guida FM, Perrone G, Vincenzi B, Amato MMC, et al. The role of macrophages polarization in predicting prognosis of radically resected gastric cancer patients. J Cell Mol Med. 2013;17(11):1415–21. doi:10.1111/Jcmm.12109.
26. Xu L, Zhu Y, Chen L, An H, Zhang W, Wang G, et al. Prognostic value of diametrically polarized tumor-associated macrophages in renal cell carcinoma. Ann Surg Oncol. 2014. doi:10.1245/s10434-014-3601-1.