Carotid arterial stiffness and risk of incident cerebral microbleeds in older people: The Age, Gene/Environment Susceptibility (AGES)-Reykjavik study

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 35, Issue 8, 2015, Pages 1889-1895

  Ding, Jie ^a   Mitchell, Gary F ^b   Bots, Michiel L ^c   Sigurdsson, Sigurdur ^d   Harris, Tamara B ^a   Garcia, Melissa ^a   Eiriksdottir, Gudny ^d   Van Buchem, Mark A ^e   Gudnason, Vilmundur ^d,f   Launer, Lenore J ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

^b CARDIOVASCULAR ENGINEERING INC   (United States)

^c UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^d ICELANDIC HEART ASSOCIATION   (Iceland)

^e LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

^f UNIVERSITY OF ICELAND   (Iceland)

Author keywords

carotid arteries; cerebral small vessel diseases; incidence; vascular stiffness

Indexed keywords

ADULT; AGED; ARTERIAL STIFFNESS; ARTICLE; BLOOD PRESSURE; BRAIN HEMORRHAGE; BRAIN INFARCTION; CARDIOVASCULAR RISK; CAROTID ARTERY; CAROTID ARTERY STIFFNESS; FEMALE; FOLLOW UP; GENOTYPE ENVIRONMENT INTERACTION; HUMAN; MAJOR CLINICAL STUDY; MALE; MEAN ARTERIAL PRESSURE; NUCLEAR MAGNETIC RESONANCE IMAGING; PRIORITY JOURNAL; PROSPECTIVE STUDY; PULSE WAVE; WHITE MATTER; YOUNG MODULUS; AGE; AGING; ARTERIAL WALL THICKNESS; CAROTID ARTERY DISEASES; CEREBRAL HEMORRHAGE; ECHOGRAPHY; GENETICS; HYPERTENSION; ICELAND; INCIDENCE; LONGITUDINAL STUDY; PATHOLOGY; PATHOPHYSIOLOGY; RISK FACTOR; TIME; VERY ELDERLY;

AGE FACTORS; AGED; AGED, 80 AND OVER; AGING; CAROTID ARTERIES; CAROTID ARTERY DISEASES; CAROTID INTIMA-MEDIA THICKNESS; CEREBRAL HEMORRHAGE; ELASTIC MODULUS; FEMALE; GENE-ENVIRONMENT INTERACTION; HUMANS; HYPERTENSION; ICELAND; INCIDENCE; LONGITUDINAL STUDIES; MAGNETIC RESONANCE IMAGING; MALE; PROSPECTIVE STUDIES; RISK FACTORS; TIME FACTORS; VASCULAR STIFFNESS;

EID: 84938061901     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.115.305451     Document Type: Article

References (30)

1. Vernooij MW, van der Lugt A, Ikram MA, Wielopolski PA, Niessen WJ, Hofman A, Krestin GP, Breteler MM., Prevalence and risk factors of cerebral microbleeds: the Rotterdam Scan Study. Neurology 2008 70 1208 1214. doi: 10.1212/01.wnl.0000307750.41970.d9
2. Sveinbjornsdottir S, Sigurdsson S, Aspelund T, Kjartansson O, Eiriksdottir G, Valtysdottir B, Lopez OL, van Buchem MA, Jonsson PV, Gudnason V, Launer LJ., Cerebral microbleeds in the population based AGES-Reykjavik study: prevalence and location. J Neurol Neurosurg Psychiatry 2008 79 1002 1006. doi: 10.1136/jnnp.2007.121913
3. Poels MM, Ikram MA, van der Lugt A, Hofman A, Niessen WJ, Krestin GP, Breteler MM, Vernooij MW., Cerebral microbleeds are associated with worse cognitive function: the Rotterdam Scan Study. Neurology 2012 78 326 333. doi: 10.1212/WNL.0b013e3182452928
4. Qiu C, Cotch MF, Sigurdsson S, Jonsson PV, Jonsdottir MK, Sveinbjrnsdottir S, Eiriksdottir G, Klein R, Harris TB, van Buchem MA, Gudnason V, Launer LJ., Cerebral microbleeds, retinopathy, and dementia: the AGES-Reykjavik Study. Neurology 2010 75 2221 2228. doi: 10.1212/WNL.0b013e3182020349
5. Vernooij MW, Heeringa J, de Jong GJ, van der Lugt A, Breteler MM., Cerebral microbleed preceding symptomatic intracerebral hemorrhage in a stroke-free person. Neurology 2009 72 763 765. doi: 10.1212/01.wnl.0000343047.74665.89
6. Charidimou A, Kakar P, Fox Z, Werring DJ., Cerebral microbleeds and recurrent stroke risk: systematic review and meta-Analysis of prospective ischemic stroke and transient ischemic attack cohorts. Stroke 2013 44 995 1001. doi: 10.1161/STROKEAHA.111.000038
7. Greenberg SM, Vernooij MW, Cordonnier C, Viswanathan A, Al-Shahi Salman R, Warach S, Launer LJ, Van Buchem MA, Breteler MM, Microbleed Study Group Cerebral microbleeds: a guide to detection and interpretation. Lancet Neurol 2009 8 165 174. doi: 10.1016/S1474-4422(09)70013-4
8. Mitchell GF, Parise H, Benjamin EJ, Larson MG, Keyes MJ, Vita JA, Vasan RS, Levy D., Changes in arterial stiffness and wave reflection with advancing age in healthy men and women: the Framingham Heart Study. Hypertension 2004 43 1239 1245. doi: 10.1161/01.HYP.0000128420.01881.aa
9. Mitchell GF, van Buchem MA, Sigurdsson S, Gotal JD, Jonsdottir MK, Kjartansson Ó Garcia M, Aspelund T, Harris TB, Gudnason V, Launer LJ., Arterial stiffness, pressure and flow pulsatility and brain structure and function: the Age, Gene/Environment Susceptibility-Reykjavik study. Brain 2011 134 Pt 11 3398 3407. doi: 10.1093/brain/awr253
10. Poels MM, Zaccai K, Verwoert GC, Vernooij MW, Hofman A, van der Lugt A, Witteman JC, Breteler MM, Mattace-Raso FU, Ikram MA., Arterial stiffness and cerebral small vessel disease: the Rotterdam Scan Study. Stroke 2012 43 2637 2642. doi: 10.1161/STROKEAHA.111.642264
11. O'Rourke MF, Safar ME., Relationship between aortic stiffening and microvascular disease in brain and kidney: cause and logic of therapy. Hypertension 2005 46 200 204. doi: 10.1161/01.HYP.0000168052.00426.65
12. Braun H, Schreiber S., Microbleeds in cerebral small vessel disease. Lancet Neurol 2013 12 735 736. doi: 10.1016/S1474-4422(13)70148-0
13. Benetos A, Laurent S, Hoeks AP, Boutouyrie PH, Safar ME., Arterial alterations with aging and high blood pressure A noninvasive study of carotid and femoral arteries. Arterioscler Thromb 1993 13 90 97
14. Yang EY, Chambless L, Sharrett AR, Virani SS, Liu X, Tang Z, Boerwinkle E, Ballantyne CM, Nambi V., Carotid arterial wall characteristics are associated with incident ischemic stroke but not coronary heart disease in the Atherosclerosis Risk in Communities (ARIC) study. Stroke 2012 43 103 108. doi: 10.1161/STROKEAHA.111.626200
15. Brisset M, Boutouyrie P, Pico F, Zhu Y, Zureik M, Schilling S, Dufouil C, Mazoyer B, Laurent S, Tzourio C, Debette S., Large-vessel correlates of cerebral small-vessel disease. Neurology 2013 80 662 669. doi: 10.1212/WNL.0b013e318281ccc2
16. Charidimou A, Werring DJ., Cerebral microbleeds and cognition in cerebrovascular disease: an update. J Neurol Sci 2012 322 50 55. doi: 10.1016/j.jns.2012.05.052
17. Song TJ, Kim J, Kim YD, Nam HS, Lee HS, Nam CM, Heo JH., The distribution of cerebral microbleeds determines their association with arterial stiffness in non-cardioembolic acute stroke patients. Eur J Neurol 2014 21 463 469. doi: 10.1111/ene.12332
18. Ochi N, Tabara Y, Igase M, Nagai T, Kido T, Miki T, Kohara K., Silent cerebral microbleeds associated with arterial stiffness in an apparently healthy subject. Hypertens Res 2009 32 255 260. doi: 10.1038/hr.2009.13
19. Agabiti-Rosei E, Mancia G, O'Rourke MF, Roman MJ, Safar ME, Smulyan H, Wang JG, Wilkinson IB, Williams B, Vlachopoulos C., Central blood pressure measurements and antihypertensive therapy: a consensus document. Hypertension 2007 50 154 160. doi: 10.1161/HYPERTENSIONAHA.107.090068
20. Ochi N, Kohara K, Tabara Y, Nagai T, Kido T, Uetani E, Ochi M, Igase M, Miki T., Association of central systolic blood pressure with intracerebral small vessel disease in Japanese. Am J Hypertens 2010 23 889 894. doi: 10.1038/ajh.2010.60
21. Vyas M, Izzo JL Jr, Lacourcière Y, Arnold JM, Dunlap ME, Amato JL, Pfeffer MA, Mitchell GF., Augmentation index and central aortic stiffness in middle-Aged to elderly individuals. Am J Hypertens 2007 20 642 647. doi: 10.1016/j.amjhyper.2007.01.008
22. van Sloten TT, Schram MT, van den Hurk K, Dekker JM, Nijpels G, Henry RM, Stehouwer CD., Local stiffness of the carotid and femoral artery is associated with incident cardiovascular events and all-cause mortality: the Hoorn study. J Am Coll Cardiol 2014 63 1739 1747. doi: 10.1016/j.jacc.2013.12.041
23. Cavalcante JL, Lima JA, Redheuil A, Al-Mallah MH., Aortic stiffness: current understanding and future directions. J Am Coll Cardiol 2011 57 1511 1522. doi: 10.1016/j.jacc.2010.12.017
24. Webb AJ, Simoni M, Mazzucco S, Kuker W, Schulz U, Rothwell PM., Increased cerebral arterial pulsatility in patients with leukoaraiosis: arterial stiffness enhances transmission of aortic pulsatility. Stroke 2012 43 2631 2636. doi: 10.1161/STROKEAHA.112.655837
25. Ong KT, Delerme S, Pannier B, Safar ME, Benetos A, Laurent S, Boutouyrie P, Investigators Aortic stiffness is reduced beyond blood pressure lowering by short-Term and long-Term antihypertensive treatment: a meta-Analysis of individual data in 294 patients. J Hypertens 2011 29 1034 1042. doi: 10.1097/HJH.0b013e328346a583
26. Wilkinson IB, Franklin SS, Hall IR, Tyrrell S, Cockcroft JR., Pressure amplification explains why pulse pressure is unrelated to risk in young subjects. Hypertension 2001 38 1461 1466
27. McEniery CM, Yasmin, Hall IR, Qasem A, Wilkinson IB, Cockcroft JR, ACCT Investigators Normal vascular aging: differential effects on wave reflection and aortic pulse wave velocity: the Anglo-Cardiff Collaborative Trial (ACCT). J Am Coll Cardiol 2005 46 1753 1760. doi: 10.1016/j.jacc.2005.07.037
28. Aribisala BS, Morris Z, Eadie E, Thomas A, Gow A, Valdés Hernández MC, Royle NA, Bastin ME, Starr J, Deary IJ, Wardlaw JM., Blood pressure, internal carotid artery flow parameters, and age-related white matter hyperintensities. Hypertension 2014 63 1011 1018. doi: 10.1161/HYPERTENSIONAHA.113.02735
29. Poels MM, Ikram MA, van der Lugt A, Hofman A, Krestin GP, Breteler MM, Vernooij MW., Incidence of cerebral microbleeds in the general population: the Rotterdam Scan Study. Stroke 2011 42 656 661. doi: 10.1161/STROKEAHA.110.607184
30. Ding J, Strachan MW, Reynolds RM, Frier BM, Deary IJ, Fowkes FG, Lee AJ, McKnight J, Halpin P, Swa K, Price JF, Edinburgh Type 2 Diabetes Study Investigators Diabetic retinopathy and cognitive decline in older people with type 2 diabetes: the Edinburgh Type 2 Diabetes Study. Diabetes 2010 59 2883 2889. doi: 10.2337/db10-0752