Prioritization methodology for the monitoring of active pharmaceutical ingredients in hospital effluents

Journal of Environmental Management

Volumn 160, Issue , 2015, Pages 324-332

  Daouk, Silwan ^a   Chèvre, Nathalie ^b   Vernaz, Nathalie ^a   Bonnabry, Pascal ^a,c   Dayer, Pierre ^a   Daali, Youssef ^a   Fleury Souverain, Sandrine ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

^c UNIVERSITY OF GENEVA   (Switzerland)

Author keywords

Environmental risk assessment; Hospital effluents; Pharmaceuticals; Predicted environmental concentrations; Prioritization

Indexed keywords

ANTIBIOTICS; AQUATIC ECOSYSTEMS; AQUATIC ORGANISMS; BIOCHEMISTRY; EFFLUENTS; RISK ASSESSMENT; TOXICITY;

ACTIVE PHARMACEUTICALS INGREDIENTS; ADVERSE EFFECT; ENVIRONMENTAL POLLUTIONS; ENVIRONMENTAL RISK ASSESSMENT; ENVIRONMENTAL TOXICITY; HOSPITAL EFFLUENT; LARGE VOLUMES; PREDICTED ENVIRONMENTAL CONCENTRATIONS; PRIORITIZATION; TOXICITY DATA;

HOSPITALS;

ANALGESIC AGENT; ANESTHETIC AGENT; ANTIBIOTIC AGENT; ANTICONVULSIVE AGENT; ANTIDEPRESSANT AGENT; ANTIINFLAMMATORY AGENT; ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CARDIOVASCULAR AGENT; LAXATIVE; MACROGOL; NONSTEROID ANTIINFLAMMATORY AGENT; DRUG; WASTE WATER; WATER POLLUTANT;

AQUATIC ECOSYSTEM; COMPARATIVE STUDY; CONCENTRATION (COMPOSITION); DRUG; EFFLUENT; ENVIRONMENTAL ASSESSMENT; ENVIRONMENTAL RISK; HOSPITAL SECTOR; HUMAN ACTIVITY; POLLUTION CONTROL; PRIORITIZATION;

ACTIVE PHARMACEUTICAL INGREDIENT EFFLUENT; ANTIMICROBIAL ACTIVITY; AQUATIC ENVIRONMENT; AQUATIC SPECIES; ARTICLE; BIOACCUMULATION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; EFFLUENT; ENVIRONMENTAL MONITORING; FLUID INTAKE; HOSPITAL WASTE; METHODOLOGY; NONHUMAN; POLLUTION; RISK ASSESSMENT; SENSITIVITY ANALYSIS; TOXICITY; WASTE WATER; WASTE WATER MANAGEMENT; WATER CYCLE; CHEMISTRY; HOSPITAL; HUMAN; PROCEDURES; WATER POLLUTANT;

SWITZERLAND;

ENVIRONMENTAL MONITORING; HOSPITALS; HUMANS; PHARMACEUTICAL PREPARATIONS; RISK ASSESSMENT; WASTE WATER; WATER POLLUTANTS, CHEMICAL;

EID: 84937978570     PISSN: 03014797     EISSN: 10958630     Source Type: Journal    
DOI: 10.1016/j.jenvman.2015.06.037     Document Type: Article

References (57)

1. Al Aukidy M., Verlicchi P., Voulvoulis N. A framework for the assessment of the environmental risk posed by pharmaceuticals originating from hospital effluents. Sci. Total Environ. 2014, 493(0):54-64.
2. Benotti M.J., Brownawell B.J. Microbial degradation of pharmaceuticals in estuarine and coastal seawater. Environ. Pollut. 2009, 157(3):994-1002.
3. Besse J.-P., Garric J. Human pharmaceuticals in surface waters: implementation of a prioritization methodology and application to the French situation. Toxicol. Lett. 2008, 176(2):104-123.
4. Besse J.-P., Kausch-Barreto C., Garric J. Exposure assessment of pharmaceuticals and their metabolites in the aquatic environment: application to the French situation and preliminary prioritization. Hum. Ecol. Risk Assess. 2008, 14(4):665-695.
5. Blair B.D., Crago J.P., Hedman C.J., Klaper R.D. Pharmaceuticals and personal care products found in the Great Lakes above concentrations of environmental concern. Chemosphere 2013, 93(9):2116-2123.
6. Bonnefin Y. Variabilité temporelle des rejets d'antibiotiques dans l'environnement: évaluation du risque dans la région lausannoise (In French) 2011, 126. Master Thesis, EPFL.
7. Bonvin F., Rutler R., Chèvre N., Halder J., Kohn T. Spatial and temporal presence of a wastewater-derived Micropollutant Plume in Lake Geneva. Environ. Sci. Technol. 2011, 45(11):4702-4709.
8. Bonvin F., Omlin J., Rutler R., Schweizer W.B., Alaimo P.J., Strathmann T.J., McNeill K., Kohn T. Direct photolysis of human metabolites of the antibiotic sulfamethoxazole: evidence for Abiotic Back-transformation. Environ. Sci. Technol. 2012, 47(13):6746-6755.
9. Chèvre N. Pharmaceuticals in surface waters: sources, behavior, ecological risk, and possible solutions. Case study of Lake Geneva, Switzerland. Wiley Interdiscip. Rev. Water 2014, 1(1):69-86.
10. Chèvre N., Coutu S., Margot J., Wynn H.K., Bader H.P., Scheidegger R., Rossi L. Substance flow analysis as a tool for mitigating the impact of pharmaceuticals on the aquatic system. Water Res. 2013, 47(9):2995-3005.
11. Coutu S., Rossi L., Barry D.A., Chèvre N. Methodology to account for uncertainties and tradeoffs in pharmaceutical environmental hazard assessment. J. Environ. Manag. 2012, 98(0):183-190.
12. Coutu S., Rossi L., Barry D.A., Rudaz S., Vernaz N. Temporal variability of antibiotics fluxes in wastewater and contribution from hospitals. PloS One 2013, 8(1):e53592.
13. Daughton C.G. Cradle-to-cradle stewardship of drugs for minimizing their environmental disposition while promoting human health. I. Rationale for and avenues toward a green pharmacy. Environ. Health Perspect. 2003, 111(5):757-774.
14. Daughton C.G., Ruhoy I.S. Green pharmacy and pharmEcovigilance: prescribing and the planet. Expert Rev. Clin. Pharmacol. 2011, 4(2):211-232.
15. de Jongh C.M., Kooij P.J.F., de Voogt P., ter Laak T.L. Screening and human health risk assessment of pharmaceuticals and their transformation products in Dutch surface waters and drinking water. Sci. Total Environ. 2012, 427-428(0):70-77.
16. de Voogt P., Sacher F., Janex-Habibi M., Bruchet A., Puijker L., Mons M. Development of an international priority list of pharmaceuticals relevant for the water cycle. Water Sci. Technol. 2008, 59(1):39-46.
17. EMEA Guidelines on the Environmental Risk Assessment of Medicinal Products for Human Use 2006, 12. European Medicines Agency, London.
18. Escher B.I., Baumgartner R., Koller M., Treyer K., Lienert J., McArdell C.S. Environmental toxicology and risk assessment of pharmaceuticals from hospital wastewater. Water Res. 2011, 45(1):75-92.
19. European Commision E Technical Guiduance Document on Risk Assessment. TGD Part II 2003, European Chemical Bureau, Institute for Health and Consumer Protection, Ispra, Italy.
20. Fent K., Weston A.A., Caminada D. Ecotoxicology of human pharmaceuticals. Aquat. Toxicol. 2006, 76(2):122-159.
21. Götz C., Singer H., Longrée P., Hollender J. Mikroverunreinigungen - Beurteilungskonzept für organische Spurenstoffe aus kommunalem Abwasser (In German) 2010, Studie im Auftrag des Bundesamt für Umwelt (BAFU), Dübendorf, Eawag.
22. Götz C., Stamm C., Fenner K., Singer H., Schärer M., Hollender J. Targeting aquatic microcontaminants for monitoring: exposure categorization and application to the Swiss situation. Environ. Sci. Pollut. Res. 2010, 17(2):341-354.
23. Helwig K., Hunter C., MacLachlan J., McNaughtan M., Roberts J., Cornelissen A., Dagot C., Evenblij H., Klepiszewski K., Lyko S., Nafo I., McArdell C., Venditti S., Pahl O. Micropollutant Point sources in the built Environment: identification and monitoring of priority pharmaceutical substances in hospital effluents. J. Environ. Anal. Toxicol. 2013, 3(177).
24. Hoeger B., Köllner B., Dietrich D.R., Hitzfeld B. Water-borne diclofenac affects kidney and gill integrity and selected immune parameters in brown trout (Salmo trutta f. fario). Aquat. Toxicol. 2005, 75(1):53-64.
25. Isidori M., Lavorgna M., Nardelli A., Pascarella L., Parrella A. Toxic and genotoxic evaluation of six antibiotics on non-target organisms. Sci. Total Environ. 2005, 346(1-3):87-98.
26. Jean J., Perrodin Y., Pivot C., Trepo D., Perraud M., Droguet J., Tissot-Guerraz F., Locher F. Identification and prioritization of bioaccumulable pharmaceutical substances discharged in hospital effluents. J. Environ. Manag. 2012, 103(0):113-121.
27. Johnson A.C., Oldenkamp R., Dumont E., Sumpter J.P. Predicting concentrations of the cytostatic drugs cyclophosphamide, carboplatin, 5-fluorouracil, and capecitabine throughout the sewage effluents and surface waters of europe. Environ. Toxicol. Chem. 2013, 32(9):1954-1961.
28. Kümmerer K. Drugs in the environment: emission of drugs, diagnostic aids and disinfectants into wastewater by hospitals in relation to other sources - a review. Chemosphere 2001, 45(6-7):957-969.
29. Kümmerer K. The presence of pharmaceuticals in the environment due to human use - present knowledge and future challenges. J. Environ. Manag. 2009, 90(8):2354-2366.
30. Kümmerer K. Antibiotics in the aquatic environment - a review - part I. Chemosphere 2009, 75(4):417-434.
31. Kümmerer K. Pharmaceuticals in the Environment. Annu. Rev. Environ. Resour. 2010, 35(1):57-75.
32. Kümmerer K., Al-Ahmad A., Mersch-Sundermann V. Biodegradability of some antibiotics, elimination of the genotoxicity and affection of wastewater bacteria in a simple test. Chemosphere 2000, 40(7):701-710.
33. Le Corre K.S., Ort C., Kateley D., Allen B., Escher B.I., Keller J. Consumption-based approach for assessing the contribution of hospitals towards the load of pharmaceutical residues in municipal wastewater. Environ. Int. 2012, 45:99-111.
34. Lienert J., Güdel K., Escher B.I. Screening method for ecotoxicological Hazard assessment of 42 pharmaceuticals considering human metabolism and excretory routes. Environ. Sci. Technol. 2007, 41(12):4471-4478.
35. Margot J., Kienle C., Magnet A., Weil M., Rossi L., de Alencastro L.F., Abegglen C., Thonney D., Chèvre N., Scharer M., Barry D.A. Treatment of micropollutants in municipal wastewater: ozone or powdered activated carbon?. Sci. total Environ. 2013, 461-462:480-498.
36. McArdell C., Kovalova L., Siegrist H., Kienle C., Moser R., Schwartz T. Input and Elimination of Pharmaceuticals and Disinfectants from Hospital Wastewater 2011, 95. Eawag, Duebendorf Switzerland.
37. Michael I., Rizzo L., McArdell C.S., Manaia C.M., Merlin C., Schwartz T., Dagot C., Fatta-Kassinos D. Urban wastewater treatment plants as hotspots for the release of antibiotics in the environment: a review. Water Res. 2013, 47(3):957-995.
38. Mullot J.-U. Modélisation des flux de médicaments dans les effluents hospitaliers (In French) 2009, 334. Faculté de pharmacie de Chatenay-Malabry, (1030) Paris-Sud 11, PhD Thesis.
39. Oaks J.L., Gilbert M., Virani M.Z., Watson R.T., Meteyer C.U., Rideout B.A., Shivaprasad H.L., Ahmed S., Chaudhry M.J., Arshad M., Mahmood S., Ali A., Khan A.A. Diclofenac residues as the cause of vulture population decline in Pakistan. Nature 2004, 427(6975):630-633.
40. Orias F., Perrodin Y. Characterisation of the ecotoxicity of hospital effluents: a review. Sci. Total Environ. 2013, 454-455(0):250-276.
41. Orias F., Perrodin Y. Pharmaceuticals in hospital wastewater: their ecotoxicity and contribution to the environmental hazard of the effluent. Chemosphere 2014, 115(0):31-39.
42. Ort C., Lawrence M.G., Reungoat J., Eaglesham G., Carter S., Keller J. Determining the fraction of pharmaceutical residues in wastewater originating from a hospital. Water Res. 2010, 44(2):605-615.
43. Ortelli D., Edder P., Rapin F., Ramseier S. Métaux et micropolluants organiques dans les rivières et les eaux du Léman (In French). Campagne 2009. Rapp Comm Int Prot Eaux Léman contre Pollut. CIPEL 2010, 57-76.
44. Ortelli D., Edder P., Rapin F., Ramseier S. Métaux et micropolluants organiques dans les rivières et les eaux du Léman (In French). Campagne 2010. Rapp Comm Int Prot Eaux Léman contre Pollut. CIPEL 2011, 65-86.
45. Ortiz de Garcia S., Pinto G.P., Garcia-Encina P.A., Mata R.I. Ranking of concern, based on environmental indexes, for pharmaceutical and personal care products: an application to the Spanish case. J. Environ. Manage 2013, 129c:384-397.
46. Pavan M., Worth A.P. Publicly-accessible QSAR software tools developed by the joint research Centre. SAR QSAR Environ. Res. 2008, 19(7-8):785-799.
47. Perazzolo C., Morasch B., Kohn T., Magnet A., Thonney D., Chèvre N. Occurrence and fate of micropollutants in the Vidy Bay of Lake Geneva, Switzerland. Part I: priority list for environmental risk assessment of pharmaceuticals. Environ. Toxicol. Chemistry/SETAC 2010, 29(8):1649-1657.
48. Santos L.H.M.L.M., Araújo A.N., Fachini A., Pena A., Delerue-Matos C., Montenegro M.C.B.S.M. Ecotoxicological aspects related to the presence of pharmaceuticals in the aquatic environment. J. Hazard. Mater. 2010, 175(1-3):45-95.
49. Santos L.H.M.L.M., Gros M., Rodriguez-Mozaz S., Delerue-Matos C., Pena A., Barceló D., Montenegro M.C.B.S.M. Contribution of hospital effluents to the load of pharmaceuticals in urban wastewaters: identification of ecologically relevant pharmaceuticals. Sci. Total Environ. 2013, 461-462(0):302-316.
50. Scheurer M., Sacher F., Brauch H.-J. Occurrence of the antidiabetic drug metformin in sewage and surface waters in Germany. J. Environ. Monit. 2009, 11(9):1608-1613.
51. Tauxe Würsch A. Wastewaters: Occurence of Pharmaceutical Substances and Genotoxicity 2005, 263. Section des Sciences et Ingénierie de l'Environnement, PhD thesis(3280) École Polytechnique Fédérale de Lausanne (EPFL).
52. Valcarcel Y., Gonzalez Alonso S., Rodriguez-Gil J.L., Gil A., Catala M. Detection of pharmaceutically active compounds in the rivers and tap water of the Madrid Region (Spain) and potential ecotoxicological risk. Chemosphere 2011, 84(10):1336-1348.
53. Verlicchi P., Al Aukidy M., Galletti A., Petrovic M., Barceló D. Hospital effluent: investigation of the concentrations and distribution of pharmaceuticals and environmental risk assessment. Sci. Total Environ. 2012, 430(0):109-118.
54. Verlicchi P., Al Aukidy M., Zambello E. Occurrence of pharmaceutical compounds in urban wastewater: removal, mass load and environmental risk after a secondary treatment-A review. Sci. Total Environ. 2012, 429(0):123-155.
55. Weissbrodt D., Kovalova L., Ort C., Pazhepurackel V., Moser R., Hollender J., Siegrist H., McArdell C.S. Mass flows of X-ray contrast Media and cytostatics in hospital wastewater. Environ. Sci. Technol. 2009, 43(13):4810-4817.
56. Wennmalm Å., Gunnarsson B. Pharmaceutical management through environmental product labeling in Sweden. Environ. Int. 2009, 35(5):775-777.
57. Yuan S., Jiang X., Xia X., Zhang H., Zheng S. Detection, occurrence and fate of 22 psychiatric pharmaceuticals in psychiatric hospital and municipal wastewater treatment plants in Beijing, China. Chemosphere 2013, 90(10):2520-2525.