The effect of menopause on the innate antiviral activity of cervicovaginal lavage

American Journal of Obstetrics and Gynecology

Volumn 213, Issue 2, 2015, Pages 204.e1-204.e6

  Chappell, Catherine A ^a   Isaacs, Charles E ^c   Xu, Weimin ^c   Meyn, Leslie A ^b   Uranker, Kevin ^b   Dezzutti, Charlene S ^a,b   Moncla, Bernard J ^a,b   Hillier, Sharon L ^a,b  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF PITTSBURGH   (United States)

^c NEW YORK STATE INSTITUTE FOR BASIC RESEARCH IN DEVELOPMENTAL DISABILITIES   (United States)

Author keywords

contraception; herpes simplex virus; human immunodeficiency virus; innate mucosal immunity; menopause

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; ANTIVIRUS AGENT; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; ORAL CONTRACEPTIVE AGENT; CONTRACEPTIVE AGENT;

ADULT; ANTIVIRAL ACTIVITY; ARTICLE; FEMALE; HERPES SIMPLEX VIRUS 1; HERPES SIMPLEX VIRUS 2; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; INNATE IMMUNITY; INTRAUTERINE CONTRACEPTIVE DEVICE; JURKAT CELL LINE; MAJOR CLINICAL STUDY; MENOPAUSE; MENSTRUAL CYCLE; NONHUMAN; PLAQUE ASSAY; POSTMENOPAUSE; PREMENOPAUSE; PRIORITY JOURNAL; PROTEIN CONTENT; VAGINAL LAVAGE; DISEASE PREDISPOSITION; HERPES SIMPLEX; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; MIDDLE AGED; UTERINE CERVIX; VAGINA; VIRAL PLAQUE ASSAY; YOUNG ADULT;

ADULT; CERVIX UTERI; CONTRACEPTIVE AGENTS, FEMALE; CONTRACEPTIVES, ORAL, COMBINED; DISEASE SUSCEPTIBILITY; FEMALE; HERPES SIMPLEX; HERPESVIRUS 1, HUMAN; HERPESVIRUS 2, HUMAN; HIV INFECTIONS; HIV-1; HUMANS; IMMUNITY, INNATE; INTRAUTERINE DEVICES, MEDICATED; LEVONORGESTREL; MEDROXYPROGESTERONE ACETATE; MENSTRUAL CYCLE; MIDDLE AGED; POSTMENOPAUSE; PREMENOPAUSE; VAGINA; VAGINAL DOUCHING; VIRAL PLAQUE ASSAY; YOUNG ADULT;

EID: 84937977837     PISSN: 00029378     EISSN: 10976868     Source Type: Journal    
DOI: 10.1016/j.ajog.2015.03.045     Document Type: Article

References (29)

1. K.A. Gebo, and R.D. Moore Treatment of HIV infection in the older patient Expert Rev Anti Infect Ther 2 2004 733 743
2. J. Prejean, R. Song, A. Hernandez, and et al. Estimated HIV incidence in the United States, 2006-2009 PLoS One 6 2011 e17502
3. G. Prati, D. Mazzoni, and B. Zani Psychosocial predictors and HIV-related behaviors of older adults verses middle-aged and younger adults J Aging Health 27 2015 123 139
4. J.A. Levy, M.G. Ory, and S. Crystal HIV/AIDS interventions for midlife and older adults: current status and challenges J Acquir Immune Defic Syndr 33 2003 S59 S67
5. C. Wira, M. Patel, M. Ghosh, L. Mukura, and J. Fahey Innate immunity in the human female reproductive tract: endocrine regulation of endogenous antimicrobial protection against HIV and other sexually transmitted infections Am J Reprod Immunol 65 2011 196 211
6. M. Ghosh, J.V. Fahey, Z. Shen, and et al. Anti-HIV activity in cervical-vaginal secretions from HIV-positive and -negative women correlate with innate antimicrobial levels and IgG antibodies PLoS One 5 2010 e11366
7. T. Lahey, M. Ghosh, J.V. Fahey, and et al. Selective impact of HIV disease progression on the innate immune system in the human female reproductive tract PLoS One 7 2012 e38100
8. B.L. Anderson, M. Ghosh, C. Raker, and et al. In vitro anti-HIV-1 activity in cervicovaginal secretions from pregnant and nonpregnant women Am J Obstet Gynecol 207 2012 65.e1 65.e10
9. C.S. Dezzutti, C.W. Hendrix, Marrazzo, and et al. Performance of swabs, lavage, and diluents to quantify biomarkers of female genital tract soluble mucosal mediators PLoS One 6 2011 e23136
10. G.F. Shust, S. Cho, M. Kim, and et al. Female genital tract secretions inhibit herpes simplex virus infection: correlation with soluble mucosal immune mediators and impact of hormonal contraception Am J Reprod Immunol 63 2010 110 119
11. C.R. Wira, J.V. Fahey, M. Rodriguez-Garcia, Z. Shen, and M.V. Patel Regulation of mucosal immunity in the female reproductive tract: the role of sex hormones in immune protection against sexually transmitted pathogens Am J Reprod Immunol 72 2014 236 258
12. M.J. Keller, E. Guzman, E. Hazrati, and et al. PRO 2000 elicits a decline in genital tract immune mediators without compromising intrinsic antimicrobial activity AIDS 21 2007 467 476
13. E.V. Valore, C.H. Park, S.L. Igreti, and T. Ganz Antimicrobial components of vaginal fluid Am J Obstet Gynecol 187 2002 561 568
14. M.V. Patel, M. Ghosh, J.V. Fahey, C. Ochsenbauer, R.M. Rossoll, and C.R. Wira Innate immunity in the vagina (part II): anti-HIV activity and antiviral content of human vaginal secretions Am J Reprod Immunol 72 2014 22 33
15. P.L. Ogra Aging and its possible impact on mucosal immune responses Aging Res Rev 9 2010 101 106
16. E.J. Goetz, M.C. Huang, J. Don, and et al. Gender specificity of altered human immune cytokine profiles in aging FASEB J 24 2010 3580 3589
17. J.L. Shaw, C. Petraki, C. Watson, A. Bocking, and E.P. Diamandis Role of tissue kallikrein-related peptidases in cervical mucus remodeling and host defense Biol Chem 389 2008 1513 1522
18. C.A. Chappell, L.C. Rohan, B.J. Moncla, and et al. The effects of reproductive hormones on the physical properties of cervicovaginal fluid Am J Obstet Gynecol 211 2014 226.e1 226.e7
19. + T cells in healthy postmenopausal women J Acquir Immune Defic Syndr 59 2012 221 228
20. C.R. Wira, M. Ghosh, J.M. Smith, and et al. Epithelial cell secretions from the human female reproductive tract inhibit sexually transmitted pathogens and Candida albicans but not Lactobacillus Mucosal Immunol 4 2011 335 342
21. C.R. Wira, J.V. Fahey, M. Ghosh, M.V. Patel, D.K. Hickey, and D.O. Ochiel Sex hormone regulation of innate immunity in the female reproductive tract: the role of epithelial cells in balancing reproductive potential with protection against sexually transmitted pathogens Am J Reprod Immunol 63 2010 544 565
22. A. Li, J.C. Felix, W. Yang, and J.K. Jain Effect of mifepristone on the expression of endometrial secretory leukocyte protease inhibitor in new medroxyprogesterone acetate users Fertil Steril 90 2008 872 875
23. D.C. Fleming, A.E. King, A.R. Williams, H.O. Critchley, and R.W. Kelly Hormonal contraception can suppress natural antimicrobial gene transcription in human endometrium Fertil Steril 79 2003 856 863
24. L. Miller, D.L. Patton, A. Meier, S.S. Thwin, T.M. Hooton, and D.A. Eschenbach Depomedroxyprogesterone-induced hypoestrogenism and changes in vaginal flora and epithelium Obstet Gynecol 96 2000 431 439
25. C.B. Polis, and K.M. Curtis Use of hormonal contraceptives and HIV acquisition in women: a systematic review of the epidemiological evidence Lancet Infect Dis 13 2013 797 808
26. R. Heffron, D. Donnell, H. Rees, and et al. Use of hormonal contraceptives and risk of HIV-1 transmission: a prospective cohort study Lancet Infect Dis 12 2012 19 26
27. J.M. Baeten, S. Benki, V. Chohan, and et al. Hormonal contraceptive use, herpes simplex virus infection, and risk of HIV-1 acquisition among Kenyan women AIDS 21 2007 1771 1777
28. C.S. Morrison, P.L. Chen, C. Kwok, and et al. Hormonal contraception and HIV acquisition: reanalysis using marginal structural modeling AIDS 24 2010 1778 1781
29. C.S. Morrison, P.L. Chen, C. Kwok, and et al. Hormonal contraception and the risk of HIV acquisition: an individual participant data meta-analysis PLoS Med 12 2015 e1001778