Targeting Notch signaling by γ-secretase inhibitor I enhances the cytotoxic effect of 5-FU in gastric cancer

Clinical and Experimental Metastasis

Volumn 32, Issue 6, 2015, Pages 593-603

  Lee, Hyun Woo ^a,b   Kim, Seok Jun ^a   Choi, Il Ju ^c   Song, Jaewhan ^b   Chun, Kyung Hee ^a  

^a Yonsei University College of Medicine   (South Korea)

^b Yonsei University   (South Korea)

^c National Cancer Center   (South Korea)

Author keywords

5 FU; Combination therapy; Gastric cancer; GSI

Indexed keywords

CASPASE 3; CASPASE 8; CXCL9 CHEMOKINE; FLUOROURACIL; GAMMA INTERFERON; GAMMA SECRETASE INHIBITOR; GAMMA SECRETASE INHIBITOR I; INTERLEUKIN 2; JAGGED1; JAGGED2; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; NOTCH RECEPTOR; NOTCH2 RECEPTOR; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BCL XL; PROTEIN KINASE B; PROTEIN P42; PROTEIN P44; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIMETABOLITE; BENZYLOXYCARBONYL-LEUCYL-LEUCYL-NORLEUCINAL; MESSENGER RNA; OLIGOPEPTIDE; SECRETASE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CANCER COMBINATION CHEMOTHERAPY; CANCER INHIBITION; CANCER REGRESSION; CANCER SIZE; CELL PROLIFERATION; CELL SURVIVAL; CLINICAL ARTICLE; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DRUG EFFICACY; DRUG POTENTIATION; DRUG SAFETY; DRUG TARGETING; ENZYME PHOSPHORYLATION; FEMALE; FLUORESCENCE ACTIVATED CELL SORTING; G2 PHASE CELL CYCLE CHECKPOINT; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; HUMAN TISSUE; IN VITRO STUDY; MOUSE; NONHUMAN; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION; STOMACH CANCER; THERAPY EFFECT; TREATMENT DURATION; WESTERN BLOTTING; ANIMAL; ANTAGONISTS AND INHIBITORS; BAGG ALBINO MOUSE; CELL ADHESION; CELL CYCLE; CELL MOTION; DRUG EFFECTS; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; STOMACH NEOPLASMS; TUMOR CELL CULTURE;

AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; BLOTTING, WESTERN; CELL ADHESION; CELL CYCLE; CELL MOVEMENT; CELL PROLIFERATION; DRUG SYNERGISM; FEMALE; FLUOROURACIL; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; MICE; MICE, INBRED BALB C; MICE, NUDE; OLIGOPEPTIDES; PHOSPHORYLATION; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, NOTCH; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; TUMOR CELLS, CULTURED; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84937969377     PISSN: 02620898     EISSN: 15737276     Source Type: Journal    
DOI: 10.1007/s10585-015-9730-5     Document Type: Article

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