Melatonin for Sleep Disorders and Cognition in Dementia: A Meta-Analysis of Randomized Controlled Trials

American Journal of Alzheimer's Disease and other Dementias

Volumn 30, Issue 5, 2015, Pages 439-447

  Xu, Jing ^a   Wang, Li Ling ^a   Dammer, Eric B ^b   Li, Chun Bo ^a   Xu, Gang ^c   Chen, Sheng Di ^a   Wang, Gang ^a  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

Author keywords

cognitive function; dementia; melatonin; meta analysis; sleep

Indexed keywords

MELATONIN; PLACEBO; CENTRAL DEPRESSANT AGENT;

ALZHEIMER DISEASE; COGNITION; DEMENTIA; DROWSINESS; DRUG EFFICACY; DRUG INDUCED HEADACHE; FOLLOW UP; GASTROINTESTINAL SYMPTOM; HUMAN; INFECTION; META ANALYSIS; MINI MENTAL STATE EXAMINATION; PAIN; PHOTOTHERAPY; RESPIRATORY TRACT DISEASE; REVIEW; SKIN TOXICITY; SLEEP DISORDER; SLEEP QUALITY; SLEEP TIME; SUSTAINED DRUG RELEASE; TREATMENT DURATION; TREMOR; COGNITION DISORDERS; COMPLICATION; DEMENTIA, VASCULAR; PSYCHOLOGY; RANDOMIZED CONTROLLED TRIAL (TOPIC); SLEEP WAKE DISORDERS;

ALZHEIMER DISEASE; CENTRAL NERVOUS SYSTEM DEPRESSANTS; COGNITION; COGNITION DISORDERS; DEMENTIA; DEMENTIA, VASCULAR; HUMANS; MELATONIN; RANDOMIZED CONTROLLED TRIALS AS TOPIC; SLEEP WAKE DISORDERS;

EID: 84937940653     PISSN: 15333175     EISSN: 19382731     Source Type: Journal    
DOI: 10.1177/1533317514568005     Document Type: Review

References (34)

1. Prince M, Bryce R, Albanese E, Wimo A, Ribeiro W, Ferri CP,. The global prevalence of dementia: a systematic review and metaanalysis. Alzheimers Dement. 2013; 9 (1): 63-75. e62.
2. Shub D, Darvishi R, Kunik ME,. Non-pharmacologic treatment of insomnia in persons with dementia. Geriatrics. 2009; 64 (2): 22-26.
3. Hart DJ, Craig D, Compton SA,. A retrospective study of the behavioural and psychological symptoms of mid and late phase Alzheimer's disease. Int J Geriatr Psychiatry. 2003; 18 (11): 1037-1042.
4. McCurry SM, Gibbons LE, Logsdon RG, Vitiello MV, Teri L,. Nighttime insomnia treatment and education for Alzheimer's disease: a randomized, controlled trial. J Am Geriatr Soc. 2005; 53 (5): 793-802.
5. Havekes R, Vecsey CG, Abel T,. The impact of sleep deprivation on neuronal and glial signaling pathways important for memory and synaptic plasticity. Cell Signal. 2012; 24 (6): 1251-1260.
6. Deuker L, Olligs J, Fell J,. Memory consolidation by replay of stimulus-specific neural activity. J. Neurosci. 2013; 33 (49): 19373-19383.
7. Xie L, Kang H, Xu Q,. Sleep drives metabolite clearance from the adult brain. Science. 2013; 342 (6156): 373-377.
8. Singer C,. Dementia in long-term care. J Am Med Dir Assoc. 2003; 4 (6 suppl): S133.
9. Tariot PN, Podgorski CA, Blazina L, Leibovici A,. Mental disorders in the nursing home: another perspective. Am J Psychiatry. 1993; 150 (7): 1063-1069.
10. Rovner BW, Kafonek S, Filipp L, Lucas MJ, Folstein MF,. Prevalence of mental illness in a community nursing home. Am J Psychiatry. 1986; 143 (11): 1446-1449.
11. Pollak CP, Perlick D, Linsner JP, Wenston J, Hsieh F,. Sleep problems in the community elderly as predictors of death and nursing home placement. J Community Health. 1990; 15 (2): 123-135.
12. Brzezinski A, Vangel MG, Wurtman RJ,. Effects of exogenous melatonin on sleep: a meta-analysis. Sleep Med Rev. 2005; 9 (1): 41-50.
13. de Jonghe A, Korevaar JC, van Munster BC, de Rooij SE,. Effectiveness of melatonin treatment on circadian rhythm disturbances in dementia. Are there implications for delirium? A systematic review. Int J Geriatr Psychiatry. 2010; 25 (12): 1201-1208.
14. Chakraborti D, Tampi DJ, Tampi RR,. Melatonin and Melatonin Agonist for Delirium in the Elderly Patients[published online June 18, 2014]. Am J Alzheimers Dis Other Demen. 2014.
15. Folstein MF, Folstein SE, McHugh PR,. "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12 (3): 189-198.
16. Rosen WG, Mohs RC, Davis KL,. A new rating scale for Alzheimer's disease. Am J Psychiatry. 1984; 141 (11): 1356-1364.
17. Higgins JPT, Green S, (eds). Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. The Cochrane Collaboration, 2011. http://www.cochrane-handbook.org. Updated March, 2011.
18. Atkins D, Best D, Briss PA,. Grading quality of evidence and strength of recommendations. BMJ. 2004; 328 (7454): 1490.
19. Serfaty M, Kennell-Webb S, Warner J, Blizard R, Raven P,. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry. 2002; 17 (12): 1120-1127.
20. Asayama K, Yamadera H, Ito T, Suzuki H, Kudo Y, Endo S,. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch. 2003; 70 (4): 334-341.
21. Singer C, Tractenberg RE, Kaye J,. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer's disease. Sleep. 2003; 26 (7): 893-901.
22. Dowling GA, Burr RL, Van Someren EJ,. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer's disease. J Am Geriatr Soc. 2008; 56 (2): 239-246.
23. Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, Van Someren EJ,. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. JAMA. 2008; 299 (22): 2642-2655.
24. Gehrman PR, Connor DJ, Martin JL, Shochat T, Corey-Bloom J, Ancoli-Israel S,. Melatonin fails to improve sleep or agitation in double-blind randomized placebo-controlled trial of institutionalized patients with Alzheimer disease. Am J Geriatr Psychiatry. 2009; 17 (2): 166-169.
25. Gao QW LY, Luo GQ, Xiang W, Peng KR,. [Effect of melatonin on mild Alzheimer's disease in elderly male patients]. Parct Geriatr. 2009; 23 (1): 56-58.
26. Furukawa TA, Barbui C, Cipriani A, Brambilla P, Watanabe N,. Imputing missing standard deviations in meta-analyses can provide accurate results. J Clin Epidemiol. 2006; 59 (1): 7-10.
27. Egger M, Davey Smith G, Schneider M, Minder C,. Bias in meta-analysis detected by a simple, graphical test. BMJ. 1997; 315 (7109): 629-634.
28. Ancoli-Israel S, Clopton P, Klauber MR, Fell R, Mason W,. Use of wrist activity for monitoring sleep/wake in demented nursing-home patients. Sleep. 1997; 20 (1): 24-27.
29. Camargos EF, Louzada FM, Nobrega OT,. Wrist actigraphy for measuring sleep in intervention studies with Alzheimer's disease patients: application, usefulness, and challenges. Sleep Med Rev. 2013; 17 (6): 475-488.
30. Jean-Louis G, von Gizycki H, Zizi F,. Melatonin effects on sleep, mood, and cognition in elderly with mild cognitive impairment. J Pineal Res. 1998; 25 (3): 177-183.
31. Cardinali DP, Vigo DE, Olivar N, Vidal MF, Furio AM, Brusco LI,. Therapeutic application of melatonin in mild cognitive impairment. Am J Neurodegener Dis. 2012; 1 (3): 280-291.
32. Furio AM, Brusco LI, Cardinali DP,. Possible therapeutic value of melatonin in mild cognitive impairment: a retrospective study. J Pineal Res. 2007; 43 (4): 404-409.
33. Wade AG, Ford I, Crawford G,. Nightly treatment of primary insomnia with prolonged release melatonin for 6 months: a randomized placebo controlled trial on age and endogenous melatonin as predictors of efficacy and safety. BMC Med. 2010; 8: 51.
34. Riley RD, Higgins JP, Deeks JJ,. Interpretation of random effects meta-analyses. BMJ. 2011; 342: d549.