Cross-talk between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis

Antioxidants and Redox Signaling

Volumn 23, Issue 4, 2015, Pages 295-306

  Carlström, Mattias ^a,b   Liu, Ming ^a   Yang, Ting ^a   Zollbrecht, Christa ^a   Huang, Liyue ^a,b   Peleli, Maria ^a   Borniquel, Sara ^a   Kishikawa, Hiroaki ^a   Hezel, Michael ^a   Persson, A Erik G ^b   Weitzberg, Eddie ^a   Lundberg, Jon O ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b UPPSALA UNIVERSITY   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ARGININE; CITRULLINE; CYCLIC GMP; NITRATE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRITE; SODIUM NITRATE; ENDOTHELIAL NITRIC OXIDE SYNTHASE; NITRIC ACID DERIVATIVE; NOS3 PROTEIN, MOUSE;

AMINO ACID BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL TISSUE; AORTA; ARTICLE; BLOOD PRESSURE; BLOOD VESSEL REACTIVITY; CONTROLLED STUDY; DIET SUPPLEMENTATION; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; MALE; MOLECULAR INTERACTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN HOMEOSTASIS; RAT; TELEMETRY; ANIMAL; BLOOD; C57BL MOUSE; CARDIOVASCULAR SYSTEM; CHEMISTRY; DIETARY SUPPLEMENT; GENETICS; HOMEOSTASIS; KNOCKOUT MOUSE; METABOLISM; PHOSPHORYLATION; SPRAGUE DAWLEY RAT;

ANIMALS; AORTA; ARGININE; BLOOD PRESSURE; CARDIOVASCULAR SYSTEM; CITRULLINE; DIETARY SUPPLEMENTS; HOMEOSTASIS; MALE; METABOLIC NETWORKS AND PATHWAYS; MICE, INBRED C57BL; MICE, KNOCKOUT; NITRATES; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE III; NITRITES; PHOSPHORYLATION; RATS, SPRAGUE-DAWLEY;

EID: 84937908177     PISSN: 15230864     EISSN: 15577716     Source Type: Journal    
DOI: 10.1089/ars.2013.5481     Document Type: Article

References (40)

1. Montellano PR, and Kemp BE. AMP-Activated protein kinase phosphorylation of endothelial NO synthase. FEBS Lett 443: 285-289, 1999.
2. Cosby K, Partovi KS, Crawford JH, Patel RP, Reiter CD, Martyr S, Yang BK, Waclawiw MA, Zalos G, Xu X, Huang KT, Shields H, Kim-Shapiro DB, Schechter AN, Cannon RO, 3rd, and Gladwin MT. Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med 9: 1498-1505, 2003.
3. Cosentino F and Katusic ZS. Tetrahydrobiopterin and dysfunction of endothelial nitric oxide synthase in coronary arteries. Circulation 91: 139-144, 1995.
4. Delp MD, Behnke BJ, Spier SA, Wu G, and Muller-Delp JM. Ageing diminishes endothelium-dependent vasodilatation and tetrahydrobiopterin content in rat skeletal muscle arterioles. J Physiol 586: 1161-1168, 2008.
5. Erwin PA, Lin AJ, Golan DE, and Michel T. Receptorregulated dynamic S-nitrosylation of endothelial nitricoxide synthase in vascular endothelial cells. J Biol Chem 280: 19888-19894, 2005.
6. Fleming I and Busse R. Signal transduction of eNOS activation. Cardiovasc Res 43: 532-541, 1999.
7. Fleming I and Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 284: R1-R12, 2003.
8. Gao Q, Zhao X, Ahmad M, and Wolin MS. Mitochondrialderived hydrogen peroxide inhibits relaxation of bovine coronary arterial smooth muscle to hypoxia through stimulation of ERK MAP kinase. Am J Physiol Heart Circ Physiol 297: H2262-H2269, 2009.
9. Gladwin MT, Schechter AN, Kim-Shapiro DB, Patel RP, Hogg N, Shiva S, Cannon RO, 3rd, Kelm M, Wink DA, Espey MG, Oldfield EH, Pluta RM, Freeman BA, Lancaster JR, Jr., Feelisch M, and Lundberg JO. The emerging biology of the nitrite anion. Nat Chem Biol 1: 308-314, 2005.
10. Huang L, Borniquel S, and Lundberg JO. Enhanced xanthine oxidoreductase expression and tissue nitrate reduction in germ free mice. Nitric Oxide 22: 191-195, 2010.
11. Jansson EA, Huang L, Malkey R, Govoni M, Nihlen C, Olsson A, Stensdotter M, Petersson J, Holm L, Weitzberg E, and Lundberg JO. A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis. Nat Chem Biol 4: 411-417, 2008.
12. Jung C, Gonon AT, Sjoquist PO, Lundberg JO, and Pernow J. Arginase inhibition mediates cardioprotection during ischaemia-reperfusion. Cardiovasc Res 85: 147-154, 2010.
13. Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ, and Ahluwalia A. Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension 56: 274-281, 2010.
14. Kumar D, Branch BG, Pattillo CB, Hood J, Thoma S, Simpson S, Illum S, Arora N, Chidlow JH, Jr., Langston W, Teng X, Lefer DJ, Patel RP, and Kevil CG. Chronic sodium nitrite therapy augments ischemia-induced angiogenesis and arteriogenesis. Proc Natl Acad Sci U S A 105: 7540-7545, 2008.
15. Lang JD, Jr., Teng X, Chumley P, Crawford JH, Isbell TS, Chacko BK, Liu Y, Jhala N, Crowe DR, Smith AB, Cross RC, Frenette L, Kelley EE, Wilhite DW, Hall CR, Page GP, Fallon MB, Bynon JS, Eckhoff DE, and Patel RP. Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation. J Clin Invest 117: 2583-2591, 2007.
16. Larsen FJ, Ekblom B, Sahlin K, Lundberg JO, and Weitzberg E. Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med 355: 2792-2793, 2006.
17. Liu R and Persson AE. Angiotensin II stimulates calcium and nitric oxide release from Macula densa cells through AT1 receptors. Hypertension 43: 649-653, 2004.
18. Lundberg JO, Gladwin MT, Ahluwalia A, Benjamin N, Bryan NS, Butler A, Cabrales P, Fago A, Feelisch M, Ford PC, Freeman BA, Frenneaux M, Friedman J, Kelm M, Kevil CG, Kim-Shapiro DB, Kozlov AV, Lancaster JR, Jr., Lefer DJ, McColl K, McCurry K, Patel RP, Petersson J, Rassaf T, Reutov VP, Richter-Addo GB, Schechter A, Shiva S, Tsuchiya K, van Faassen EE, Webb AJ, Zuckerbraun BS, Zweier JL, and Weitzberg E. Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol 5: 865-869, 2009.
19. Lundberg JO and Govoni M. Inorganic nitrate is a possible source for systemic generation of nitric oxide. Free Radic Biol Med 37: 395-400, 2004.
20. Lundberg JO, Weitzberg E, Cole JA, and Benjamin N. Nitrate, bacteria and human health. Nat Rev Microbiol 2: 593-602, 2004.
21. Lundberg JO, Weitzberg E, and Gladwin MT. The nitratenitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov 7: 156-167, 2008.
22. Lundberg JO, Weitzberg E, Lundberg JM, and Alving K. Intragastric nitric oxide production in humans: measurements in expelled air. Gut 35: 1543-1546, 1994.
23. Martinez-Ruiz A, Villanueva L, Gonzalez de Orduna C, Lopez-Ferrer D, Higueras MA, Tarin C, Rodriguez-Crespo I, Vazquez J, and Lamas S. S-nitrosylation of Hsp90 promotes the inhibition of its ATPase and endothelial nitric oxide synthase regulatory activities. Proc Natl Acad Sci U S A 102: 8525-8530, 2005.
24. Moncada S and Higgs A. The L-Arginine-nitric oxide pathway. N Engl J Med 329: 2002-2012, 1993.
25. Moncada S and Higgs EA. The discovery of nitric oxide and its role in vascular biology. Br J Pharmacol 147 Suppl 1: S193-S201, 2006.
26. Mount PF, Kemp BE, and Power DA. Regulation of endothelial and myocardial NO synthesis by multi-site eNOS phosphorylation. J Mol Cell Cardiol 42: 271-279, 2007.
27. Mulvany MJ and Halpern W. Contractile properties of small arterial resistance vessels in spontaneously hypertensive and normotensive rats. Circ Res 41: 19-26, 1977.
28. Patzak A, Mrowka R, Storch E, Hocher B, and Persson PB. Interaction of angiotensin II and nitric oxide in isolated perfused afferent arterioles of mice. J Am Soc Nephrol 12: 1122-1127, 2001.
29. Raat NJ, Noguchi AC, Liu VB, Raghavachari N, Liu D, Xu X, Shiva S, Munson PJ, and Gladwin MT. Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response. Free Radic Biol Med 47: 510-517, 2009.
30. Salter M, Knowles RG, and Moncada S. Widespread tissue distribution, species distribution and changes in activity of Ca(2 + )-dependent and Ca(2 + )-independent nitric oxide synthases. FEBS Lett 291: 145-149, 1991.
31. Schulz R, Rassaf T, Massion PB, Kelm M, and Balligand JL. Recent advances in the understanding of the role of nitric oxide in cardiovascular homeostasis. Pharmacol Ther 108: 225-256, 2005.
32. Spiegelhalder B, Eisenbrand G, and Preussmann R. Influence of dietary nitrate on nitrite content of human saliva: possible relevance to in vivo formation of N-nitroso compounds. Food Cosmet Toxicol 14: 545-548, 1976.
33. Thomas SR, Witting PK, and Drummond GR. Redox control of endothelial function and dysfunction: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal 10: 1713-1765, 2008.
34. Toda N, Ayajiki K, and Okamura T. Interaction of endothelial nitric oxide and angiotensin in the circulation. Pharmacol Rev 59: 54-87, 2007.
35. Weber M, Lauer N, Mulsch A, and Kojda G. The effect of peroxynitrite on the catalytic activity of soluble guanylyl cyclase. Free Radic Biol Med 31: 1360-1367, 2001.
36. Weitzberg E and Lundberg JO. Nonenzymatic nitric oxide production in humans. Nitric Oxide 2: 1-7, 1998.
37. Wolin MS. Reactive oxygen species and the control of vascular function. Am J Physiol Heart Circ Physiol 296: H539-H549, 2009.
38. Zeballos GA, Bernstein RD, Thompson CI, Forfia PR, Seyedi N, Shen W, Kaminiski PM, Wolin MS, and Hintze TH. Pharmacodynamics of plasma nitrate/nitrite as an indication of nitric oxide formation in conscious dogs. Circulation 91: 2982-2988, 1995.
39. Zweier JL, Samouilov A, and Kuppusamy P. Non-enzymatic nitric oxide synthesis in biological systems. Biochim Biophys Acta 1411: 250-262, 1999.
40. Zweier JL, Wang P, Samouilov A, and Kuppusamy P. Enzyme-independent formation of nitric oxide in biological tissues. Nat Med 1: 804-809, 1995.