Validation of multiple-breath washout equipment: From bench to clinic and possible pitfalls

Respiration

Volumn 87, Issue 6, 2014, Pages 456-458

  Latzin, Philipp ^a   Thompson, Bruce ^b  

^a UNIVERSITY CHILDREN S HOSPITAL   (Switzerland)

^b MONASH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ASTHMA; BODY PLETHYSMOGRAPHY; BREATH ANALYSIS; CYSTIC FIBROSIS; EQUIPMENT; FUNCTIONAL RESIDUAL CAPACITY; GAS FLOW; HUMAN; LUNG CLEARANCE; LUNG DISEASE; LUNG VOLUME; MULTIPLE BREATH WASHOUT EQUIPMENT; NOTE; PRIORITY JOURNAL; SPIROMETRY; TIDAL VOLUME; LUNG FUNCTION TEST; PHOTOACOUSTICS; PHYSIOLOGY; PROCEDURES; ALGORITHM; FLOW MEASUREMENT; MEASUREMENT ERROR; RESPIRATORY THERAPEUTIC DEVICE; VALIDATION STUDY;

FUNCTIONAL RESIDUAL CAPACITY; HUMANS; PHOTOACOUSTIC TECHNIQUES; RESPIRATORY FUNCTION TESTS;

EID: 84902292036     PISSN: 00257931     EISSN: 14230356     Source Type: Journal    
DOI: 10.1159/000362420     Document Type: Note

References (23)

1. Singer F, Kieninger E, Abbas C, Yammine S, et al: Practicability of nitrogen multiplebreath washout measurements in a pediatric cystic fibrosis outpatient setting. Pediatr Pulmonol 2013; 48: 739-746.
2. Kieninger E, Singer F, Fuchs O, Abbas C, et al: Long-term course of lung clearance index between infancy and school-age in cystic fibrosis subjects. J Cyst Fibros 2011; 10: 487-490.
3. Fuchs SI, Ellemunter H, Eder J, Mellies U, et al: Feasibility and variability of measuring the lung clearance index in a multi-center setting. Pediatr Pulmonol 2012; 47: 649-657.
4. Vermeulen F, Proesmans M, Boon M, Havermans T, et al: Lung clearance index predicts pulmonary exacerbations in young patients with cystic fibrosis. Thorax 2014; 69: 39-45.
5. Subbarao P, Stanojevic S, Brown M, Jensen R, et al: Lung clearance index as an outcome measure for clinical trials in young children with cystic fibrosis. A pilot study using inhaled hypertonic saline. Am J Respir Crit Care Med 2013; 188: 456-460.
6. Owens CM, Aurora P, Stanojevic S, Bush A, et al: Lung clearance index and HRCT are complementary markers of lung abnormalities in young children with CF. Thorax 2011; 66: 481-488.
7. Farah CS, King GG, Brown NJ, Downie SR, et al: The role of the small airways in the clinical expression of asthma in adults. J Allergy Clin Immunol 2012; 129: 381.e1-387e1.
8. Farah CS, King GG, Brown NJ, Peters MJ, et al: Ventilation heterogeneity predicts asthma control in adults following inhaled corticosteroid dose titration. J Allergy Clin Immunol 2012; 130: 61-78.
9. Verbanck S, Schuermans D, Paiva M, Vincken W: The functional benefit of anti-inflammatory aerosols in the lung periphery. J Allergy Clin Immunol 2006; 118: 340-346. (Pubitemid 44142721)
10. Thompson BR, Douglass JA, Ellis MJ, Kelly VJ, et al: Peripheral lung function in patients with stable and unstable asthma. J Allergy Clin Immunol 2013; 131: 1322-1328.
11. Lahzami S, Schoeffel RE, Pechey V, Reid C, et al: Small airways function declines after allogeneic haematopoietic stem cell transplantation. Eur Respir J 2011; 38: 1180-1188.
12. Verbanck S, Schuermans D, Paiva M, Meysman M, et al: Small airway function improvement after smoking cessation in smokers without airway obstruction. Am J Respir Crit Care Med 2006; 174: 853-857. (Pubitemid 44564784)
13. Thompson BR, Hodgson YM, Kotsimbos T, Liakakos P, et al: Bronchiolitis obliterans syndrome leads to a functional deterioration of the acinus post lung transplant. Thorax, DOI: 10.1136/thoraxjnl-2013-204671.
14. Robinson PD, Latzin P, Verbanck S, Hall GL, et al: Consensus statement for inert gas washout measurement using multiple-and singlebreath tests. Eur Respir J 2013; 41: 507-522.
15. Gonem S, Singer F, Corkill S, Singapuri A, Siddiqui S, Gustafsson P: Validation of a photoacoustic gas analyser for the measurement of functional residual capacity using multiple-breath inert gas washout. Respiration 2014; 87: 462-468.
16. Lum S, Stocks J, Stanojevic S, Wade A, et al: Age and height dependence of lung clearance index and functional residual capacity. Eur Respir J 2013; 41: 1371-1377.
17. Verbanck S, Thompson BR, Schuermans D, Kalsi H, et al: Ventilation heterogeneity in the acinar and conductive zones of the normal ageing lung. Thorax 2012; 67: 789-795.
18. Singer F, Houltz B, Robinson P, Latzin P, et al: Bench test of a mass spectrometer based multiple-breath washout system using a realistic lung model. Eur Respir J 2012; 40(suppl 56): P4602.
19. Schmidt A, Yammine S, Proietti E, Frey U, et al: Validation of multiple-breath washout equipment for infants and young children. Pediatr Pulmonol, DOI: 10.1002/ppul.23010.
20. Singer F, Houltz B, Latzin P, Robinson P, et al: A realistic validation study of a new nitrogen multiple-breath washout system. PLoS One 2012; 7:e36083.
21. Brunner JX, Wolff G, Cumming G, Langenstein H: Accurate measurement of N2 volumes during N2 washout requires dynamic adjustment of delay time. J Appl Physiol 1985; 59: 1008-1012. (Pubitemid 16223434)
22. Yammine S, Singer F, Gustafsson P, Latzin P: Impact of different breathing protocols on multiple-breath washout outcomes in children. J Cyst Fibros 2014; 13: 190-197.
23. Stuart-Andrews CR, Kelly VJ, Sands SA, Lewis AJ, et al: Automated detection of the phase III slope during inert gas washout testing. J Appl Physiol (1985) 2012; 112: 1073-1081.