How meaningful are risk determinations in the absence of a complete dataset? Making the case for publishing standardized test guideline and 'no effect' studies for evaluating the safety of nanoparticulates versus spurious 'high effect' results from single investigative studies

Science and Technology of Advanced Materials

Volumn 16, Issue 3, 2015, Pages

  Warheit, David B ^a   Donner, E Maria ^b  

^a CHEMOURS COMPANY   (United States)

^b DUPONT COMPANY   (United States)

Author keywords

biokinetic studies; guideline studies; nanoparticles; no effect studies; oral toxicity studies; standardized studies; titanium dioxide

Indexed keywords

NANOPARTICLES; NANOTECHNOLOGY; OXIDES; PUBLISHING; RATS; SAFETY ENGINEERING; TITANIUM; TITANIUM DIOXIDE; TOXICITY;

BIOKINETIC STUDIES; GUIDELINE STUDIES; HEALTH AND SAFETY ISSUES; INVESTIGATIVE ANALYSIS; NANOSCALE TITANIUM DIOXIDE; ORAL TOXICITY STUDIES; ORGANIZATION FOR ECONOMIC CO-OPERATION AND DEVELOPMENT; STANDARDIZED STUDIES;

RISK ASSESSMENT;

EID: 84937873393     PISSN: 14686996     EISSN: None     Source Type: Journal    
DOI: 10.1088/1468-6996/16/3/034603     Document Type: Article

References (12)

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9. Himmelstein M W, Ramsey J B, Boatman R J and Warheit D B 2015 Pharmacokinetic comparison of 2 titanium dioxide (1 pigment and 1 nanostructured) materials demonstrate absence of systemic exposure in orally exposed rats Toxicologist 144 450-1
10. MacNicoll A, Kelly M, Aksoy H, Kramer E, Bouwmeester H and Chaudhry Q 2015 A study of the uptake and biodistribution of nano-titanium dioxide using in vitro and in vivo models of oral intake J. Nanopart. Res. 17 66
11. Jones K, Morton J, Smith I, Jurkschat K, Harding A H and Evans G 2015 Human in vivo and in vitro studies on gastrointestinal absorption of titanium dioxide nanoparticles Toxicol. Lett. 233 95-101
12. DuPont - Repeated-dose oral Toxicity 28-Day Gavage Study in Rats with Pigment-Grade Titanium Dioxide (OECD Guideline for the Testing of Chemicals; Section 4: Health Effects Number 407 1995) (Unpublished data 2006)