Repetitive Transcranial Magnetic Stimulation (rTMS) improves symptoms and reduces clinical illness in patients suffering from OCD - Results from a single-blind, randomized clinical trial with sham cross-over condition

Journal of Psychiatric Research

Volumn 68, Issue , 2015, Pages 238-244

  Haghighi, Mohammad ^a   Shayganfard, Mehran ^a   Jahangard, Leila ^a   Ahmadpanah, Mohammad ^a   Bajoghli, Hafez ^b   Pirdehghan, Azar ^a   Holsboer Trachsler, Edith ^c   Brand, Serge ^c,d  

^a HAMADAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^b TEHRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

^c UNIVERSITY OF BASEL   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

Obsessive compulsive disorder (OCD); Repetitive Transcranial Magnetic Stimulation (rTMS); Sham condition

Indexed keywords

CLOMIPRAMINE; SEROTONIN UPTAKE INHIBITOR; PLACEBO;

ADULT; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; CLINICAL GLOBAL IMPRESSION SCALE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE SEVERITY; ELECTRONEUROLOGY; FEMALE; HUMAN; MALE; OBSESSIVE COMPULSIVE DISORDER; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PRODROMAL SYMPTOM; PSYCHOPHARMACOTHERAPY; RANDOMIZED CONTROLLED TRIAL; SELF REPORT; SHAM PROCEDURE; SINGLE BLIND PROCEDURE; TIME TO TREATMENT; TRANSCRANIAL MAGNETIC STIMULATION; TRANSCRANIAL MAGNETIC STIMULATION SYSTEM; TREATMENT DURATION; TREATMENT INDICATION; TREATMENT RESPONSE; YALE BROWN OBSESSIVE COMPULSIVE SCALE; CROSSOVER PROCEDURE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; PROCEDURES;

ADULT; CROSS-OVER STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; OBSESSIVE-COMPULSIVE DISORDER; OUTCOME ASSESSMENT (HEALTH CARE); PATIENT OUTCOME ASSESSMENT; PLACEBOS; SINGLE-BLIND METHOD; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 84937853470     PISSN: 00223956     EISSN: 18791379     Source Type: Journal    
DOI: 10.1016/j.jpsychires.2015.06.020     Document Type: Article

References (38)

1. Ackerman D.L., Greenland S. Multivariate meta-analysis of controlled drug studies for obsessive-compulsive disorder. J.Clin. Psychopharmacol. 2002, 22:309-317.
2. American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders 2000, American Psychiatric Association, Washington, DC. fourth ed.
3. Baxter L.R., Ackermann R.F., Swerdlow N.R., Brody A., Saxena S., Schwartz J.M. Specific brain system mediation of obsessive-compulsive disorder responsive to either medication of behavior therapy. Obsessive-compulsive Disorder: Contemporary Issues and Treatment 2000, 573-609. Lawrence Erlbaum Associates, Mahwah NJ, US. W.K. Goodman, M.V. Rudorfer (Eds.).
4. Berlim M.T., Neufeld N.H., Van den Eynde F. Repetitive transcranial magnetic stimulation (rTMS) for obsessive-compulsive disorder (OCD): an exploratory meta-analysis of randomized and sham-controlled trials. J.Psychiatr. Res. 2013, 47:999-1006.
5. Blom R.M., Figee M., Vulink N., Denys D. Update on repetitive transcranial magnetic stimulation in obsessive-compulsive disorder: different targets. Curr. Psychiatry Rep. 2011, 13:289-294.
6. First M.B., Gibbon M., Spitzer R.L., Williams J.B.W., Benjamin L.S. Structured Clinical Interview for DSM-IV Axis II Personality Disorders 1997, American Psychiatric Press, Inc., Washington, DC, (SCID-II).
7. Foa E.B., Liebowitz M.R., Kozak M.J., Davies S., Campeas R., Franklin M.E., et al. Randomized, placebo-controlled trial of exposure and ritual prevention, clomipramine, and their combination in the treatment of obsessive-compulsive disorder. Am. J. Psychiatry 2005, 162:151-161.
8. Franklin M.E., Foa E.B. Treatment of obsessive compulsive disorder. Annu. Rev. Clin. Psychol. 2011, 7:229-243.
9. Grabill K., Merlo L., Duke D., Harford K.L., Keeley M.L., Geffken G.R., Storch E.A. Assessment of obsessive-compulsive disorder: a review. J.Anxiety Disord. 2008, 22:1-17.
10. Ghaleiha A., Entezari N., Modabbernia A., Najand B., Askari N., Tabrizi M., et al. Memantine add-on in moderate to severe obsessive-compulsive disorder: randomized double-blind placebo-controlled study. J.Psychiatr. Res. 2013, 47:175-180.
11. Goodman W.K., Price L.H., Rasmussen S.A., Mazure C., Delgado P., Heninger G.R., et al. The Yale-Brown Obsessive Compulsive Scale. II. Validity. Arch. Gen. Psychiatry 1989, 46:1012-1016.
12. Guy W. Clinical Global Impression Scale. The ECDEU Assessment Manual for Psychopharmacology-Revised 1976, 218-222. DHEW Publ., No Adm. 76, 338.
13. Haghighi M., Jahangard L., Mohammad-Beigi H., Bajoghli H., Hafezian H., Rahimi A., et al. In a double-blind, randomized and placebo-controlled trial, adjuvant memantine improved symptoms in inpatients suffering from refractory obsessive-compulsive disorders (OCD). Psychopharmacol 2013, 228:633-640.
14. Hezel D.M., Beattie K., Stewart S.E. Memantine as an augmenting agent for severe pediatric OCD. Am. J. Psychiatry 2009, 166:237.
15. Hollander E. Obsessive-compulsive disorder-related disorders: the role of selective serotonergic reuptake inhibitors. Int. Clin. Psychopharmacol. 1996, 11:75-87.
16. Jaafari N., Rachid F., Rotge J.Y., Polosan M., El-Hage W., Belin D., et al. Safety and efficacy of repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder: a review. World J. Biol. Psychiatry 2012, 13:164-177.
17. Kang J.I., Kim C.H., Namkoong K., Lee C.I., Kim S.J. Arandomized controlled study of sequentially applied repetitive transcranial magnetic stimulation in obsessive-compulsive disorders. J.Clin. Psychol. 2009, 70:1645-1651.
18. Karno M., Golding J.M., Sorenson S.B., Burnam M.A. The epidemiology of obsessive-compulsive disorder in five US communities. Arch. Gen. Psychiatry 1988, 45:1094-1099.
19. Kessler R.C., Berglund P., Demler O., Jin R., Merikangas K.R., Walters E.E. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication. Arch. Gen. Psychiatry 2005, 62:593-602.
20. Leon T., Garcia M.J., Danke I., Toro P. Resting state in obsessive-compulsive disorder. A review of the literature. Actas Esp. Psiquiatr. 2014, 42:250-258.
21. Ma X., Huang Y., Liao L., Jin Y. Arandomized double-blinded sham-controlled trial of α electroencephalogram-guided transcranial magnetic stimulation for obsessive-compulsive disorder. Chin. Med. J. 2014, 127:601.
22. Mantovani A., Simpson H.B., Fallon B.A., Rossi S., Lisanby S.H. Randomized sham-controlled trial of repetitive transcranial magnetic stimulation in treatment-resistant obsessive-compulsive disorder. Int. J. Neuropsychopharmacol. 2010, 13:217-227.
23. Mataix-Cols D., Rauch S.L., Baer L., Eisen J.L., Shera D.M., Goodman W.K., et al. Symptom stability in adult obsessive-compulsive disorder: data from a naturalistic two-year follow-up study. Am. J. Psychiatry 2002, 159:263-268.
24. Nakao T., Okada K., Kanba S. Neurobiological model of obsessive-compulsive disorder: evidence from recent neuropsychological and neuroimaging findings. Psychiatry Clin. Neurosci. 2014, 68:587-605.
25. Pallanti S., Quercioli L. Treatment-refractory obsessive-compulsive disorder: methodological issues, operational definitions and therapeutic lines. Prog. Neuropsychopharmacol. Biol. Psychiatry 2006, 30:400-412.
26. Piras F., Piras F., Caltagirone C., Spalletta G. Brain circuitries of obsessive compulsive disorder: a systematic review and meta-analysis of diffusion tensor imaging studies. Neurosci. Biobehav Rev. 2013, 37:2856-2877.
27. Rauch S.L., Dougherty D.D., Shin L.M., Albert N., Manzo P., Leahy L., et al. Neural correlates of factor-analyzed OCD symptom dimensions: a PET study. CNS Spectr. 1998, 3:37-43.
28. Ridding M.C., Rothwell J.C. Is there a future for therapeutic use of transcranial magnetic stimulation?. Nat. Rev. Neurosci. 2007, 8:559-567.
29. Ruffini C., Locatelli M., Lucca A., Benedetti F., Insacco C., Smeraldi E. Augmentation effect of repetitive transcranial magnetic stimulation over the orbitofrontal cortex in drug-resistant obsessive-compulsive disorder patients: a controlled investigation. Prim. Care Companion - J. Clin. Psychiatry 2009, 11:226-230.
30. Ruscio A.M., Stein D.J., Chiu W.T., Kessler R.C. The epidemiology of obsessive-compulsive disorder in the National Comorbidity Survey Replication. Mol. Psychiatry 2010, 15:53-63.
31. Sachdev P.S., Loo C.K., Mitchell P.B., McFarquhar T.F., Malhi G.S. Repetitive transcranial magnetic stimulation for the treatment of obsessive compulsive disorder: a double-blind controlled investigation. Psychol. Med. 2007, 37:1645-1649.
32. Sarkhel S., Sinha V.K., Praharaj S.K. Adjunctive high-frequency right prefrontal repetitive transcranial magnetic stimulation (rTMS) was not effective in obsessive-compulsive disorder but improved secondary depression. J.Anxiety Dis. 2010, 24:535-539.
33. Saxena S., Brody A.L., Ho M.L., Alborzian S., Ho M.K., Maidment K.M., Huang S.C., Wu H.M., Au S.C., Baxter L.R. Cerebral metabolism in major depression and obsessive-compulsive disorder occurring separately and concurrently. Biol. Psychiatry 2001 Aug 1, 50(3):159-170.
34. Siebner H.R., Filipovic S.R., Rowe J.B., Cordivari C., Gerschlager W., Rothwell J.C., et al. Patients with focal arm dystonia have increased sensitivity to slow-frequency repetitive TMS of the dorsal premotor cortex. Brain 2003, 126:2710-2725.
35. Stewart S.E., Jenike E.A., Hezel D.M., Stack D.E., Dodman N.H., Shuster L., Jenike M.A. Asingle-blinded case-control study of memantine in severe obsessive-compulsive disorder. J.Clin. Psychopharmacol. 2010, 30:34-39.
36. Swedo S.E., Snider L.A. The neurobiology and treatment of obsessive compulsive disorder. Neurobiology of Mental Illness 2004, 628-638. Oxford University Press, New York. E.J. Nestler, D.S. Charney (Eds.).
37. Wu K., Hanna G.L., Rosenberg D.R., Arnold P.D. The role of glutamate signaling in the pathogenesis and treatment of obsessive-compulsive disorder. Pharmacol. Biochem. Behav. 2012, 100:726-735.
38. Yoo S.S., Gujar N., Hu P., Jolesz F.A., Walker M.P. The human emotional brain without sleep-a prefrontal amygdala disconnect. Curr. Biol. 2007 Oct 23, 17(20):R877-R878.