Predictive value of IL-8 for sepsis and severe infections after burn injury: A clinical study

Shock

Volumn 43, Issue 3, 2015, Pages 222-227

  Kraft, Robert ^a   Herndon, David N ^a   Finnerty, Celeste C ^a,b   Cox, Robert A ^a   Song, Juquan ^c   Jeschke, Marc G ^d  

^a SHRINERS HOSPITALS FOR CHILDREN   (United States)

^b UNIVERSITY OF TEXAS MEDICAL BRANCH   (United States)

^c UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

Biomarker; Burn; IL 8; Infection; MOF; Mortality; Organ failure; Sepsis

Indexed keywords

ACUTE PHASE PROTEIN; BILIRUBIN; C REACTIVE PROTEIN; CREATININE; INTERLEUKIN 10; INTERLEUKIN 12P70; INTERLEUKIN 13; INTERLEUKIN 1BETA; INTERLEUKIN 6; INTERLEUKIN 8; AUTACOID; BIOLOGICAL MARKER; IL8 PROTEIN, HUMAN;

ACUTE PHASE RESPONSE; ARTICLE; BILIRUBIN BLOOD LEVEL; BODY SURFACE; BURN; BURN INFECTION; BURN PATIENT; CREATININE BLOOD LEVEL; FEMALE; HUMAN; INFLAMMATION; LIVER DYSFUNCTION; MAJOR CLINICAL STUDY; MALE; MULTIPLE ORGAN FAILURE; OUTCOME ASSESSMENT; PREDICTIVE VALUE; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SEPSIS; UREA NITROGEN BLOOD LEVEL; ADOLESCENT; BLOOD; CHILD; CLINICAL TRIAL; COMPLICATION; INFECTION; KAPLAN MEIER METHOD; MORTALITY; PRESCHOOL CHILD; PROSPECTIVE STUDY;

ADOLESCENT; BIOMARKERS; BURNS; CHILD; CHILD, PRESCHOOL; FEMALE; HUMANS; INFECTION; INFLAMMATION MEDIATORS; INTERLEUKIN-8; KAPLAN-MEIER ESTIMATE; MALE; MULTIPLE ORGAN FAILURE; PREDICTIVE VALUE OF TESTS; PROSPECTIVE STUDIES; SEPSIS;

EID: 84937845260     PISSN: 10732322     EISSN: 15400514     Source Type: Journal    
DOI: 10.1097/SHK.0000000000000294     Document Type: Article

References (39)

1. Herndon DN, Spies M: Modern burn care. Semin Pediatr Surg 10:28Y31, 2001.
2. Jeschke MG, Norbury WB, Finnerty CC, Mlcak RP, Kulp GA, Branski LK, Gauglitz GG, Herndon B, Swick A, Herndon DN: Age differences in inflammatory and hypermetabolic postburn responses. Pediatrics 121:497Y507, 2008.
3. Pensler JM, Herndon DN, Ptak H, Bonds E, Rutan TC, Desai MH, Abston S: Fungal sepsis: an increasing problem in major thermal injuries. J Burn Care Rehabil 7:488Y491, 1986.
4. Church D, Elsayed S, Reid O, Winston B, Lindsay R: Burn wound infections. Clin Microbiol Rev 19:403Y434, 2006.
5. Finnerty CC, Herndon DN, Przkora R, Pereira CT, Oliveira HM, Queiroz DM, Rocha AM, Jeschke MG: Cytokine expression profile over time in severely burned pediatric patients. Shock 26:13Y19, 2006.
6. Finnerty CC, Jeschke MG, Herndon DN, Gamelli R, Gibran N, KleinM, Silver G, Arnoldo B, Remick D, Tompkins RG: Temporal cytokine profiles in severely burned patients: a comparison of adults and children. Mol Med 14:553Y560, 2008.
7. Xia ZF, Coolbaugh MI, He F, Herndon DN, Papaconstantinou J: The effects of burn injury on the acute phase response. J Trauma 32:245Y250, 1992.
8. Klein MB, Silver G, Gamelli RL, Gibran NS, Herndon DN, Hunt JL, Tompkins RG: Inflammation and the host response to injury: an overview of the multicenter study of the genomic and proteomic response to burn injury. J Burn Care Res 27:448Y451, 2006.
9. Jeschke MG, Mlcak RP, Finnerty CC, Norbury WB, Gauglitz GG, Kulp GA, Herndon DN: Burn size determines the inflammatory and hypermetabolic response. Crit Care 11:R90, 2007.
10. Gauglitz GG, Song J, Herndon DN, Finnerty CC, Boehning D, Barral JM, Jeschke MG: Characterization of the inflammatory response during acute and post-acute phases after severe burn. Shock 30:503Y507, 2008.
11. Cairns BA, Barnes CM, Mlot S, Meyer AA, Maile R: Toll-like receptor 2 and 4 ligation results in complex altered cytokine profiles early and late after burn injury. J Trauma 64:1069Y1077, 2008.
12. Finnerty CC, Herndon DN, Chinkes DL, Jeschke MG: Serum cytokine differences in severely burned children with and without sepsis. Shock 27:4Y9, 2007.
13. Finnerty CC, Jeschke MG, Qian WJ, Kaushal A, Xiao W, Liu T, Gritsenko MA, Moore RJ, Camp DG 2nd, Moldawer LL, et al.: Determination of burn patient outcome by large-scale quantitative discovery proteomics. Crit Care Med 41:1421Y1434, 2013.
14. Gauglitz GG, Finnerty CC, Herndon DN, Mlcak RP, Jeschke MG: Are serum cytokines early predictors for the outcome of burn patients with inhalation injuries who do not survive? Crit Care 12:R81, 2008.
15. Xie TX, Xia Z, Zhang N, Gong W, Huang S: Constitutive NF-kappaB activity regulates the expression of VEGF and IL-8 and tumor angiogenesis of human glioblastoma. Oncol Rep 23:725Y732, 2010.
16. Rajarathnam K, Sykes BD, Kay CM, Dewald B, Geiser T, Baggiolini M, Clark-Lewis I: Neutrophil activation by monomeric interleukin-8. Science 264:90Y92, 1994.
17. Schinkel S, Schinkel C, Pollard V, Garofallo R, Heberle H, Reisner P, Papaconstantinou J, Herndon DN: Effects of endotoxin on serum chemokines in man. Eur J Med Res 10:76Y80, 2005.
18. Cox RA, Burke AS, Traber DL, Herndon DN, Hawkins HK: Production of proinflammatory polypeptides by airway mucous glands and its potential significance. Pulm Pharmacol Ther 20:172Y177, 2007.
19. Jeschke MG, Chinkes DL, Finnerty CC, Kulp G, Suman OE, Norbury WB, Branski LK, Gauglitz GG, Mlcak RP, Herndon DN: Pathophysiologic response to severe burn injury. Ann Surg 248:387Y401, 2008.
20. Petzelbauer P, Watson CA, Pfau SE, Pober JS: IL-8 and angiogenesis: evidence that human endothelial cells lack receptors and do not respond to IL-8 in vitro. Cytokine 7:267Y272, 1995.
21. Porreca E, Sergi R, Baccante G, Reale M, Orsini L, Febbo CD, Caselli G, Cuccurullo F, Bertini R: Peripheral blood mononuclear cell production of interleukin-8 and IL-8Ydependent neutrophil function in hypercholesterolemic patients. Atherosclerosis 146:345Y350, 1999.
22. Lowman HB, Fairbrother WJ, Slagle PH, Kabakoff R, Liu J, Shire S, Hebert CA: Monomeric variants of IL-8: effects of side chain substitutions and solution conditions upon dimer formation. Protein Sci 6:598Y608, 1997.
23. Finnerty CC, Ali A, McLean J, Benjamin N, Clayton RP, Andersen CR, Mlcak RP, Suman OE, MeyerW, Herndon DN: Impact of stress-induced diabetes on outcomes in severely burned children. J Am Coll Surg 218:783Y795, 2014.
24. Kraft R, Herndon DN, Al-Mousawi AM, Williams FN, Finnerty CC, Jeschke MG: Burn size and survival probability in paediatric patients in modern burn care: a prospective observational cohort study. Lancet 379:1013Y1021, 2012.
25. Hart DW, Wolf SE, Chinkes DL, Gore DC, Mlcak RP, Beauford RB, Obeng MK, Lal S, Gold WF, Wolfe RR, et al.: Determinants of skeletal muscle catabolism after severe burn. Ann Surg 232:455Y465, 2000.
26. HartDW, Wolf SE, Mlcak R, Chinkes DL, Ramzy PI, Obeng MK, Ferrando AA, Wolfe RR, Herndon DN: Persistence of muscle catabolism after severe burn. Surgery 128:312Y319, 2000.
27. Mlcak RP, Jeschke MG, Barrow RE, Herndon DN: The influence of age and gender on resting energy expenditure in severely burned children. Ann Surg 244:121Y130, 2006.
28. Greenhalgh DG, Saffle JR, Holmes JHt, Gamelli RL, Palmieri TL, Horton JW, Tompkins RG, Traber DL, Mozingo DW, Deitch EA, et al.: American Burn Association consensus conference to define sepsis and infection in burns. J Burn Care Res 28:776Y790, 2007.
29. Bone RC, Sibbald WJ, Sprung CL: The ACCP-SCCM consensus conference on sepsis and organ failure. Chest 101:1481Y1483, 1992.
30. Kraft R, Herndon DN, Finnerty CC, Shahrokhi S, Jeschke MG: Occurrence of multiorgan dysfunction in pediatric burn patients: incidence and clinical outcome. Ann Surg 259:381Y387, 2014.
31. Jeschke MG, Finnerty CC, Suman OE, Kulp G, Mlcak RP, Herndon DN: The effect of oxandrolone on the endocrinologic, inflammatory, and hypermetabolic responses during the acute phase postburn. Ann Surg 246:351Y360, 2007.
32. Barrow RE, Przkora R, Hawkins HK, Barrow LN, Jeschke MG, Herndon DN: Mortality related to gender, age, sepsis, and ethnicity in severely burned children. Shock 23:485Y487, 2005.
33. Traber DL, Linares HA, Herndon DN, Prien T: The pathophysiology of inhalation injuryVa review. Burns Incl Therm Inj 14:357Y364, 1988.
34. Barret JP, Herndon DN: Modulation of inflammatory and catabolic responses in severely burned children by early burn wound excision in the first 24 hours. Arch Surg 138:127Y132, 2003.
35. Takahashi H, Tsuda Y, Takeuchi D, Kobayashi M, Herndon DN, Suzuki F: Influence of systemic inflammatory response syndrome on host resistance against bacterial infections. Crit Care Med 32:1879Y1885, 2004.
36. Levy MM, Fink MP, Marshall JC, Abraham E, Angus D, Cook D, Cohen J, Opal SM, Vincent JL, Ramsay G: 2001 SCCM/ESICM/ACCP/ATS/SIS International Sepsis Definitions Conference. Crit Care Med 31:1250Y1256, 2003.
37. Sikora JP, Chlebna-Sokol D, Andrzejewska E, Chrul S, Polakowska E,Wysocka A, Sikora A: Clinical evaluation of proinflammatory cytokine inhibitors (sTNFR I, sTNFR II, IL-1 ra), anti-inflammatory cytokines (IL-10, IL-13) and activation of neutrophils after burn-induced inflammation. Scand J Immunol 68:145Y152, 2008.
38. Dasu MR, Spies M, Barrow RE, Herndon DN: Matrix metalloproteinases and their tissue inhibitors in severely burned children. Wound Repair Regen 11:177Y180, 2003.
39. Dasu MR, Barrow RE, Spies M, Herndon DN: Matrix metalloproteinase expression in cytokine stimulated human dermal fibroblasts. Burns 29: 527Y531, 2003.