Internal mammary and medial supraclavicular irradiation in breast cancer

New England Journal of Medicine

Volumn 373, Issue 4, 2015, Pages 317-327

  Poortmans, P M ^a,b   Collette, S ^h   Kirkove, C ⁱ   Van Limbergen, E ^j   Budach, V ^k   Struikmans, H ^c,d   Collette, L ^h   Fourquet, A ^m   Maingon, P ⁿ   Valli, M ^q,s   De Winter, K ^b   Marnitz, S ^k   Barillot, I ^n,o   Scandolaro, L ^s   Vonk, E ^e   Rodenhuis, C ^d   Marsiglia, H ^p   Weidner, N ^l   Van Tienhoven, G ^f   Glanzmann, C ^r   Kuten, A ^t   Arriagada, R ^u   Bartelink, H ^g   Van Den Bogaert, W ^a   more..

^a RADBOUD UNIVERSITY MEDICAL CENTER   (Netherlands)

^b Institute Verbeeten   (Netherlands)

^c MEDICAL CENTER HAAGLANDEN   (Netherlands)

^d UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^e Radiotherapeutic Institute Stedendriehoek en Omstreken   (Netherlands)

^f ACADEMIC MEDICAL CENTER   (Netherlands)

^g ANTONI VAN LEEUWENHOEK HOSPITAL   (Netherlands)

^h European Organization for Research and Treatment of Cancer (EORTC) Headquarters   (Netherlands)

ⁱ CLINIQUES UNIVERSITAIRES SAINT LUC   (Belgium)

^j UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^k CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^l UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^m INSTITUT CURIE   (France)

ⁿ CENTRE GEORGES FRANÇOIS LECLERC   (France)

^o UNIVERSITÉ DE TOURS   (France)

^p INSTITUT GUSTAVE ROUSSY   (France)

^q REGIONAL HOSPITAL OF LUGANO   (Switzerland)

^r UNIVERSITY HOSPITAL ZURICH   (Switzerland)

^s SANT ANNA HOSPITAL   (Italy)

^t RAMBAM MEDICAL CENTER   (Israel)

^u Grupo Oncológico Cooperativo Chileno de Investi gación GOCCHI   (Chile)

more..

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER GROWTH; CANCER LOCALIZATION; CANCER MORTALITY; CANCER RADIOTHERAPY; CONTROLLED STUDY; DISEASE FREE SURVIVAL; FEMALE; FOLLOW UP; HEART MUSCLE FIBROSIS; HUMAN; INTERNAL MAMMARY AND MEDIAL SUPRACLAVICULAR LYMPH NODE IRRADIATION; LUNG FIBROSIS; MAJOR CLINICAL STUDY; MASTECTOMY; OVERALL SURVIVAL; PARTIAL MASTECTOMY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; REGIONAL NODAL IRRADIATION; THORACIC WALL IRRADIATION; WHOLE BREAST IRRADIATION; ADVERSE EFFECTS; BREAST NEOPLASMS; CLINICAL TRIAL; KAPLAN MEIER METHOD; LYMPH NODE DISSECTION; LYMPHATIC METASTASIS; METASTASIS; MIDDLE AGED; MORTALITY; MULTICENTER STUDY; MULTIMODALITY CANCER THERAPY; RADIATION DOSE; SEGMENTAL MASTECTOMY; SENTINEL LYMPH NODE BIOPSY; SURVIVAL; THORAX WALL; YOUNG ADULT;

ANTINEOPLASTIC AGENT;

ADULT; AGED; ANTINEOPLASTIC AGENTS; BREAST NEOPLASMS; COMBINED MODALITY THERAPY; FEMALE; FOLLOW-UP STUDIES; HUMANS; KAPLAN-MEIER ESTIMATE; LYMPH NODE EXCISION; LYMPHATIC METASTASIS; MASTECTOMY, SEGMENTAL; MIDDLE AGED; NEOPLASM METASTASIS; RADIATION DOSAGE; RADIOTHERAPY; SENTINEL LYMPH NODE BIOPSY; SURVIVAL ANALYSIS; THORACIC WALL; YOUNG ADULT;

EID: 84937830189     PISSN: 00284793     EISSN: 15334406     Source Type: Journal    
DOI: 10.1056/NEJMoa1415369     Document Type: Article

References (40)

1. Heuts EM, van der Ent FW, von Meyen-feldt MF, Voogd AC. Internal mammary lymph drainage and sentinel node biopsy in breast cancer-a study on 1008 patients. Eur J Surg Oncol 2009; 35: 252-7.
2. Estourgie SH, Nieweg OE, Olmos RA, Rutgers EJ, Kroon BB. Lymphatic drainage patterns from the breast. Ann Surg 2004;239:232-7.
3. Huang O, Wang L, Shen K, et al. Breast cancer subpopulation with high risk of internal mammary lymph nodes metastasis: analysis of 2, 269 Chinese breast cancer patients treated with extended radical mastectomy. Breast Cancer Res Treat 2008;107:379-87.
4. Veronesi U, Marubini E, Mariani L, Valagussa P, Zucali R. The dissection of internal mammary nodes does not improve the survival of breast cancer patients: 30-year results of a randomised trial. Eur J Cancer 1999; 35: 1320-5.
5. Chen RC, Lin NU, Golshan M, Harris JR, Bellon JR. Internal mammary nodes in breast cancer: diagnosis and implications for patient management-a systematic review. J Clin Oncol 2008; 26: 4981-9.
6. Veronesi U, Arnone P, Veronesi P, et al. The value of radiotherapy on metastat-ic internal mammary nodes in breast cancer: results on a large series. Ann Oncol 2008;19:1553-60.
7. Cuzick J, Stewart HJ, Peto R, et al. Overview of randomized trials of postoperative adjuvant radiotherapy in breast cancer. Recent Results Cancer Res 1988; 111:108-29.
8. Arriagada R, Lê MG, Mouriesse H, et al. Long-term effect of internal mammary chain treatment: results of a multivariate analysis of 1195 patients with operable breast cancer and positive axillary nodes. Radiother Oncol 1988;11:213-22.
9. Arriagada R, Rutqvist LE, Mattsson A, Kramar A, Rotstein S. Adequate loco-regional treatment for early breast cancer may prevent secondary dissemination. J Clin Oncol 1995; 13: 2869-78.
10. Early Breast Cancer Trialists' Collaborative Group. Effects of radiotherapy and surgery in early breast cancer: an overview of the randomized trials. N Engl J Med 1995;333:1444-55.
11. Overgaard M, Hansen PS, Overgaard J, et al. Postoperative radiotherapy in high-risk premenopausal women with breast cancer who receive adjuvant chemotherapy. N Engl J Med 1997; 337: 949-55.
12. Overgaard M, Jensen MB, Overgaard J, et al. Postoperative radiotherapy in high-risk postmenopausal breast-cancer patients given adjuvant tamoxifen: Danish Breast Cancer Cooperative Group DBCG 82c randomised trial. Lancet 1999; 353: 1641-8.
13. Ragaz J, Jackson SM, Le N, et al. Adjuvant radiotherapy and chemotherapy in node-positive premenopausal women with breast cancer. N Engl J Med 1997; 337: 956-62.
14. Musat E, Poortmans P, Van den Bogaert W, et al. Quality assurance in breast cancer: EORTC experiences in the phase III trial on irradiation of the internal mammary nodes. Eur J Cancer 2007; 43: 718-24.
15. Lievens Y, Poortmans P, Van den Bogaert W. A glance on quality assurance in EORTC study 22922 evaluating techniques for internal mammary and medial supraclavicular lymph node chain irradiation in breast cancer. Radiother Oncol 2001;60:257-65.
16. Poortmans P, Kouloulias V, van Tien-hoven G, et al. Quality assurance in the EORTC randomized trial 22922/10925 investigating the role of irradiation of the internal mammary and medial supracla-vicular lymph node chain works. St rahlen-ther Onkol 2006;182:576-82.
17. Matzinger O, Heimsoth I, Poortmans P, et al. Toxicity at three years with and without irradiation of the internal mammary and medial supraclavicular lymph node chain in stage I to III breast cancer (EORTC trial 22922/10925). Acta Oncol 2010;49:24-34.
18. McGale P, Taylor C, Correa C, et al. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet 2014;383:2127-35.
19. Early Breast Cancer Trialists' Collaborative Group (EBCTCG). Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10, 801 women in 17 randomised trials. Lancet 2011; 378: 1707-16.
20. Prosnitz RG, Hubbs JL, Evans ES, et al. Prospective assessment of radiotherapy-associated cardiac toxicity in breast cancer patients: analysis of data 3 to 6 years after treatment. Cancer 2007; 110: 1840-50.
21. Roychoudhuri R, Robinson D, Putcha V, Cuzick J, Darby S, Møller H. Increased cardiovascular mortality more than fifteen years after radiotherapy for breast cancer: a population-based study. BMC Cancer 2007;7: 9.
22. Bird BR, Swain SM. Cardiac toxicity in breast cancer survivors: review of potential cardiac problems. Clin Cancer Res 2008;14:14-24.
23. Senkus-Konefka E, Jassem J. Cardiovascular effects of breast cancer radiotherapy. Cancer Treat Rev 2007; 33: 578-93.
24. Doyle JJ, Neugut AI, Jacobson JS, et al. Radiation therapy, cardiac risk factors, and cardiac toxicity in early-stage breast cancer patients. Int J Radiat Oncol Biol Phy s 2007;68:82-93.
25. Correa CR, Litt HI, Hwang WT, Ferrari VA, Solin LJ, Harris EE. Coronary artery findings after left-sided compared with right-sided radiation treatment for early-stage breast cancer. J Clin Oncol 2007;25:3031-7.
26. Hooning MJ, Botma A, Aleman BM, et al. Long-term risk of cardiovascular disease in 10-year survivors of breast cancer. J Natl Cancer Inst 2007; 99: 365-75.
27. Harris EE, Correa C, Hwang WT, et al. Late cardiac mortality and morbidity in early-stage breast cancer patients after breast-conservation treatment. J Clin Oncol 2006;24:4100-6.
28. Darby SC, Ewertz M, McGale P, et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 2013;368:987-98.
29. Taylor CW, McGale P, Povall JM, et al. Estimating cardiac exposure from breast cancer radiotherapy in clinical practice. Int J Radiat Oncol Biol Phys 2009; 73: 1061-8.
30. Osman SO, Hol S, Poortmans PM, Essers M. Volumetric modulated arc therapy and breath-hold in image-guided loco-regional left-sided breast irradiation. Ra-diother Oncol 2014;112:17-22.
31. Offersen BV, Boersma LJ, Kirkove C, et al. ESTRO consensus guideline on target volume delineation for elective radiation therapy of early stage breast cancer. Radiother Oncol 2015;114:3-10.
32. Poortmans P. Postmastectomy radiation in breast cancer with one to three involved lymph nodes: ending the debate. Lancet 2014;383:2104-6.
33. Whelan TJ, Olivotto IA, Parulekar WR, et al. Regional nodal irradiation in early-stage breast cancer. N Engl J Med 2015; 373: 307-16.
34. Hennequin C, Bossard N, Servagi-Vernat S, et al. Ten-year survival results of a randomized trial of irradiation of internal mammary nodes after mastectomy. Int J Radiat Oncol Biol Phys 2013; 86: 860-6.
35. Krengli M, Sacco M, Loi G, et al. Pulmonary changes after radiotherapy for conservative treatment of breast cancer: a prospective study. Int J Radiat Oncol Biol Phys 2008;70:1460-7.
36. Lind P. Clinical relevance of pulmonary toxicity in adjuvant breast cancer irradiation. Acta Oncol 2006; 45: 13-5.
37. Muren LP, Maurstad G, Hafslund R, Anker G, Dahl O. Cardiac and pulmonary doses and complication probabilities in standard and conformal tangential irradiation in conservative management of breast cancer. Radiother Oncol 2002; 62: 173-83.
38. Poortmans PM, Venselaar JL, Struik-mans H, et al. The potential impact of treatment variations on the results of radiotherapy of the internal mammary lymph node chain: a quality-assurance report on the dummy run of EORTC Phase III randomized trial 22922/10925 in Stage I-III breast cancer. Int J Radiat Oncol Biol Phys 2001;49:1399-408.
39. Thorsen LBJ, Berg M, Brodersen HJ, et al. Improved survival with internal mammary node irradiation: a prospective study on 3, 072 breast cancer patients. Presented at the 33rd Congress of the European Society for Therapeutic Radiology and Oncology, Vienna, April 4-8, 2014. abstract.
40. Thorsen LB, Thomsen MS, Berg M, et al. CT-planned internal mammary node radiotherapy in the DBCG-IMN study: benefit versus potentially harmful effects. Act a Oncol 2014; 53: 1027-34.