Screening for α-synuclein immunoreactive neuronal inclusions in the hippocampus allows identification of atypical MSA (FTLD-synuclein)

Acta Neuropathologica

Volumn 130, Issue 2, 2015, Pages 299-301

  Rohan, Zdenek ^a,b   Rahimi, Jasmin ^c   Weis, Serge ^d   Kapas, Istvan ^e   Auff, Eduard ^c   Mitrovic, Nenad ^f   Liberski, Pawel P ^g   Sikorska, Beata ^g   Matej, Radoslav ^a,b   Kovacs, Gabor G ^c  

^a Thomayer's Teaching Hospital   (Czech Republic)

^b CHARLES UNIVERSITY   (Czech Republic)

^c MEDICAL UNIVERSITY OF VIENNA   (Austria)

^d KEPLER UNIVERSITY HOSPITAL   (Austria)

^e ST JOHN'S HOSPITAL   (Hungary)

^f Salzkammergut Klinikum   (Austria)

^g MEDICAL UNIVERSITY OF LODZ   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SYNUCLEIN;

ADULT; AGED; AKINETIC MUTISM; BRAIN STEM; CELL INCLUSION; CEREBELLUM; CLINICAL ARTICLE; DENTATE GYRUS; DYSARTHRIA; DYSPHAGIA; ELECTROENCEPHALOGRAM; FEMALE; FRONTOTEMPORAL DEMENTIA; GAIT DISORDER; GAZE PARALYSIS; GRANULE CELL; HIPPOCAMPAL CA1 REGION; HIPPOCAMPUS; HUMAN; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LETTER; NERVE DEGENERATION; NEUROFIBRILLARY TANGLE; NEURONAL CYTOPLASMIC INCLUSION; PARKINSONISM; PRIORITY JOURNAL; PROGRESSIVE SUPRANUCLEAR PALSY; SHY DRAGER SYNDROME; SUBICULUM; BRAIN; METABOLISM; PATHOLOGY;

ALPHA-SYNUCLEIN; BRAIN; FEMALE; FRONTOTEMPORAL LOBAR DEGENERATION; HUMANS; MULTIPLE SYSTEM ATROPHY;

EID: 84937813557     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-015-1455-7     Document Type: Letter

References (10)

1. Alafuzoff I, Arzberger T, Al-Sarraj S et al (2008) Staging of neurofibrillary pathology in Alzheimer’s disease: a study of the BrainNet Europe Consortium. Brain Pathol 18:484–496
2. Aoki N, Boyer PJ, Lund C et al (2015) Atypical multiple system atrophy is a new subtype of frontotemporal lobar degeneration: frontotemporal lobar degeneration associated with alpha-synuclein. Acta Neuropathol. doi:10.1007/s00401-015-1442-z
3. Braak H, Alafuzoff I, Arzberger T, Kretzschmar H, Del Tredici K (2006) Staging of Alzheimer disease-associated neurofibrillary pathology using paraffin sections and immunocytochemistry. Acta Neuropathol 112:389–404
4. Kovacs GG, Budka H (2010) Current concepts of neuropathological diagnostics in practice: neurodegenerative diseases. Clin Neuropathol 29:271–288
5. Kovacs GG, Majtenyi K, Spina S et al (2008) White matter tauopathy with globular glial inclusions: a distinct sporadic frontotemporal lobar degeneration. J Neuropathol Exp Neurol 67:963–975
6. Landqvist Waldo M, Gustafson L, Passant U, Englund E (2015) Psychotic symptoms in frontotemporal dementia: a diagnostic dilemma? Int Psychogeriatr 27:531–539
7. Milenkovic I, Petrov T, Kovacs GG (2014) Patterns of hippocampal tau pathology differentiate neurodegenerative dementias. Dement Geriatr Cogn Disord 38:375–388
8. Sikorska B, Papierz W, Preusser M, Liberski PP, Budka H (2007) Synucleinopathy with features of both multiple system atrophy and dementia with Lewy bodies. Neuropathol Appl Neurobiol 33:126–129
9. Thal DR, Rub U, Orantes M, Braak H (2002) Phases of A beta-deposition in the human brain and its relevance for the development of AD. Neurology 58:1791–1800
10. Trojanowski JQ, Revesz T (2007) Proposed neuropathological criteria for the post mortem diagnosis of multiple system atrophy. Neuropathol Appl Neurobiol 33:615–620