Poly-Electrophilic Sesquiterpene Lactones from Vernonia amygdalina: New Members and Differences in Their Mechanism of Thiol Trapping and in Bioactivity

Journal of Natural Products

Volumn 78, Issue 7, 2015, Pages 1618-1623

  Sinisi, Annamaria ^a   Millán, Estrella ^b   Abay, Solomon M ^c,d   Habluetzel, Annette ^c   Appendino, Giovanni ^e   Muñoz, Eduardo ^b   Taglialatela Scafati, Orazio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b Instituto de Salud Carlos III   (Spain)

^c UNIVERSITY OF CAMERINO   (Italy)

^d ADDIS ABABA UNIVERSITY   (Ethiopia)

^e UNIVERSITY OF EASTERN PIEDMONT   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

LACTONE; MERCAPTAMINE; RECEPTOR ACTIVATOR OF NUCLEAR FACTOR KAPPA B; SESQUITERPENE LACTONE; STAT3 PROTEIN; THIOL; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; NFE2L2 PROTEIN, HUMAN; SESQUITERPENE; THIOL DERIVATIVE; TRANSCRIPTION FACTOR NRF2; VERNODALOL; VERNOLIDE;

ARTICLE; BIOLOGICAL ACTIVITY; CANCER CELL CULTURE; CELL CYCLE S PHASE; CYTOSTASIS; ELECTROPHILICITY; GYMNANTHEMUM AMYGDALINUM; HUMAN; HUMAN CELL; MALE; NUCLEAR MAGNETIC RESONANCE; PROSTATE CANCER CELL LINE; CELL CYCLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG EFFECTS; ISOLATION AND PURIFICATION; PLANT LEAF; VERNONIA;

VERNONIA AMYGDALINA;

CELL CYCLE; CYSTEAMINE; HUMANS; LACTONES; MOLECULAR STRUCTURE; NF-E2-RELATED FACTOR 2; NF-KAPPA B; PLANT LEAVES; SESQUITERPENES; STAT3 TRANSCRIPTION FACTOR; SULFHYDRYL COMPOUNDS; VERNONIA;

EID: 84937790135     PISSN: 01633864     EISSN: 15206025     Source Type: Journal    
DOI: 10.1021/acs.jnatprod.5b00179     Document Type: Article

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