Rho-associated kinase signaling is required for osteopontin-induced cell invasion through inactivating cofilin in human non-small cell lung cancer cell lines

Bioorganic and Medicinal Chemistry Letters

Volumn 25, Issue 9, 2015, Pages 1956-1960

  Kang, Chi Gu ^a   Han, Hwa Jeong ^a   Lee, Hyo Jeong ^a   Kim, Sung Hoon ^a   Lee, Eun Ok ^a  

^a Kyung Hee University   (South Korea)

Author keywords

A549 cells; AKT; Cofilin; FAK; Invasion; Lamellipodia; NSCLC; Osteopontin; PI3K; ROCK1

Indexed keywords

ACTIN DEPOLYMERIZING FACTOR; OSTEOPONTIN; RHO KINASE;

ANTAGONISTS AND INHIBITORS; DRUG EFFECTS; FEMALE; HUMAN; LUNG TUMOR; METABOLISM; NON SMALL CELL LUNG CANCER; PATHOLOGY; PREGNANCY; SIGNAL TRANSDUCTION; TUMOR CELL LINE; TUMOR INVASION;

ACTIN DEPOLYMERIZING FACTORS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; FEMALE; HUMANS; LUNG NEOPLASMS; NEOPLASM INVASIVENESS; OSTEOPONTIN; PREGNANCY; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION;

EID: 84937763625     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2015.03.024     Document Type: Article

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