Novel pyrrole carboxamide inhibitors of JAK2 as potential treatment of myeloproliferative disorders

Bioorganic and Medicinal Chemistry

Volumn 23, Issue 10, 2015, Pages 2387-2407

  Brasca, Maria Gabriella ^a   Gnocchi, Paola ^a   Nesi, Marcella ^a   Amboldi, Nadia ^a   Avanzi, Nilla ^a   Bertrand, Jay ^a   Bindi, Simona ^a   Canevari, Giulia ^a   Casero, Daniele ^a   Ciomei, Marina ^a   Colombo, Nicoletta ^a   Cribioli, Sabrina ^a   Fachin, Gabriele ^a   Felder, Eduard R ^a   Galvani, Arturo ^a   Isacchi, Antonella ^a   Motto, Ilaria ^a   Panzeri, Achille ^a   Donati, Daniele ^a  

^a NERVIANO MEDICAL SCIENCES   (Italy)

Author keywords

Anti cancer agents; JAK2; Myeloproliferative disorders; Protein kinase inhibitor; Tumour cell proliferation inhibition

Indexed keywords

AMIDE; ANTINEOPLASTIC AGENT; JAK2 PROTEIN, HUMAN; JANUS KINASE 2; PROTEIN KINASE INHIBITOR; PYRROLE DERIVATIVE;

ANIMAL; ANTAGONISTS AND INHIBITORS; CELL PROLIFERATION; CHEMISTRY; DRUG EFFECTS; DRUG SCREENING; ENZYMOLOGY; FEMALE; GENE EXPRESSION; GENETICS; HIGH THROUGHPUT SCREENING; HUMAN; LEUKEMIA, MEGAKARYOBLASTIC, ACUTE; MEGAKARYOBLAST; METABOLISM; MOLECULAR DOCKING; MOLECULAR DYNAMICS; MOUSE; NUDE MOUSE; PATHOLOGY; STRUCTURE ACTIVITY RELATION; SYNTHESIS; TUMOR CELL LINE;

AMIDES; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CELL PROLIFERATION; FEMALE; GENE EXPRESSION; HIGH-THROUGHPUT SCREENING ASSAYS; HUMANS; JANUS KINASE 2; LEUKEMIA, MEGAKARYOBLASTIC, ACUTE; MEGAKARYOCYTE PROGENITOR CELLS; MICE; MICE, NUDE; MOLECULAR DOCKING SIMULATION; MOLECULAR DYNAMICS SIMULATION; PROTEIN KINASE INHIBITORS; PYRROLES; STRUCTURE-ACTIVITY RELATIONSHIP; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84937759563     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2015.03.059     Document Type: Article

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