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Volumn 45, Issue 1, 2015, Pages 28-34

Effectiveness, tolerability, and safety of subcutaneous methotrexate in early rheumatoid arthritis: A retrospective analysis of real-world data from the St. Gallen cohort

Author keywords

Methotrexate; Rheumatoid arthritis; Subcutaneous

Indexed keywords

C REACTIVE PROTEIN; METHOTREXATE; PREDNISOLONE; ANTIRHEUMATIC AGENT; BIOLOGICAL PRODUCT;

EID: 84937727375     PISSN: 00490172     EISSN: 1532866X     Source Type: Journal    
DOI: 10.1016/j.semarthrit.2015.02.009     Document Type: Article
Times cited : (28)

References (40)
  • 1
    • 0036021133 scopus 로고    scopus 로고
    • Effectiveness profiles and dose dependent retention of traditional disease modifying antirheumatic drugs for rheumatoid arthritis. An observational study
    • Aletaha D., Smolen J.S. Effectiveness profiles and dose dependent retention of traditional disease modifying antirheumatic drugs for rheumatoid arthritis. An observational study. J Rheumatol 2002, 29:1631-1638.
    • (2002) J Rheumatol , vol.29 , pp. 1631-1638
    • Aletaha, D.1    Smolen, J.S.2
  • 3
    • 13244295795 scopus 로고    scopus 로고
    • Long term safety of methotrexate in routine clinical care: discontinuation is unusual and rarely the result of laboratory abnormalities
    • Yazici Y., Sokka T., Kautiainen H., Swearingen C., Kulman I., Pincus T. Long term safety of methotrexate in routine clinical care: discontinuation is unusual and rarely the result of laboratory abnormalities. Ann Rheum Dis 2005, 64:207-211.
    • (2005) Ann Rheum Dis , vol.64 , pp. 207-211
    • Yazici, Y.1    Sokka, T.2    Kautiainen, H.3    Swearingen, C.4    Kulman, I.5    Pincus, T.6
  • 4
    • 0033848342 scopus 로고    scopus 로고
    • Longterm methotrexate use in rheumatoid arthritis: 12 year followup of 460 patients treated in community practice
    • Wluka A., Buchbinder R., Mylvaganam A., Hall S., Harkness A., Lewis D., et al. Longterm methotrexate use in rheumatoid arthritis: 12 year followup of 460 patients treated in community practice. J Rheumatol 2000, 27:1864-1871.
    • (2000) J Rheumatol , vol.27 , pp. 1864-1871
    • Wluka, A.1    Buchbinder, R.2    Mylvaganam, A.3    Hall, S.4    Harkness, A.5    Lewis, D.6
  • 5
    • 0026548634 scopus 로고
    • Long-term prospective study of the use of methotrexate in the treatment of rheumatoid arthritis. Update after a mean of 90 months
    • Kremer J.M., Phelps C.T. Long-term prospective study of the use of methotrexate in the treatment of rheumatoid arthritis. Update after a mean of 90 months. Arthritis Rheum 1992, 35:138-145.
    • (1992) Arthritis Rheum , vol.35 , pp. 138-145
    • Kremer, J.M.1    Phelps, C.T.2
  • 6
    • 31044442965 scopus 로고    scopus 로고
    • The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment
    • Breedveld F.C., Weisman M.H., Kavanaugh A.F., Cohen S.B., Pavelka K., van Vollenhoven R., et al. The PREMIER study: a multicenter, randomized, double-blind clinical trial of combination therapy with adalimumab plus methotrexate versus methotrexate alone or adalimumab alone in patients with early, aggressive rheumatoid arthritis who had not had previous methotrexate treatment. Arthritis Rheum 2006, 54:26-37.
    • (2006) Arthritis Rheum , vol.54 , pp. 26-37
    • Breedveld, F.C.1    Weisman, M.H.2    Kavanaugh, A.F.3    Cohen, S.B.4    Pavelka, K.5    van Vollenhoven, R.6
  • 7
    • 48149100741 scopus 로고    scopus 로고
    • Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial
    • Emery P., Breedveld F.C., Hall S., Durez P., Chang D.J., Robertson D., et al. Comparison of methotrexate monotherapy with a combination of methotrexate and etanercept in active, early, moderate to severe rheumatoid arthritis (COMET): a randomised, double-blind, parallel treatment trial. Lancet 2008, 372:375-382.
    • (2008) Lancet , vol.372 , pp. 375-382
    • Emery, P.1    Breedveld, F.C.2    Hall, S.3    Durez, P.4    Chang, D.J.5    Robertson, D.6
  • 8
    • 85027919018 scopus 로고    scopus 로고
    • Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study
    • Kavanaugh A., Fleischmann R.M., Emery P., Kupper H., Redden L., Guerette B., et al. Clinical, functional and radiographic consequences of achieving stable low disease activity and remission with adalimumab plus methotrexate or methotrexate alone in early rheumatoid arthritis: 26-week results from the randomised, controlled OPTIMA study. Ann Rheum Dis 2013, 72:64-71.
    • (2013) Ann Rheum Dis , vol.72 , pp. 64-71
    • Kavanaugh, A.1    Fleischmann, R.M.2    Emery, P.3    Kupper, H.4    Redden, L.5    Guerette, B.6
  • 9
    • 8444239359 scopus 로고    scopus 로고
    • Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial
    • St Clair E.W., van der Heijde D.M., Smolen J.S., Maini R.N., Bathon J.M., Emery P., et al. Combination of infliximab and methotrexate therapy for early rheumatoid arthritis: a randomized, controlled trial. Arthritis Rheum 2004, 50:3432-3443.
    • (2004) Arthritis Rheum , vol.50 , pp. 3432-3443
    • St Clair, E.W.1    van der Heijde, D.M.2    Smolen, J.S.3    Maini, R.N.4    Bathon, J.M.5    Emery, P.6
  • 10
    • 78650645377 scopus 로고    scopus 로고
    • Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial
    • Tak P.P., Rigby W.F., Rubbert-Roth A., Peterfy C.G., van Vollenhoven R.F., Stohl W., et al. Inhibition of joint damage and improved clinical outcomes with rituximab plus methotrexate in early active rheumatoid arthritis: the IMAGE trial. Ann Rheum Dis 2011, 70:39-46.
    • (2011) Ann Rheum Dis , vol.70 , pp. 39-46
    • Tak, P.P.1    Rigby, W.F.2    Rubbert-Roth, A.3    Peterfy, C.G.4    van Vollenhoven, R.F.5    Stohl, W.6
  • 11
    • 65349176911 scopus 로고    scopus 로고
    • Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors
    • Westhovens R., Robles M., Ximenes A.C., Nayiager S., Wollenhaupt J., Durez P., et al. Clinical efficacy and safety of abatacept in methotrexate-naive patients with early rheumatoid arthritis and poor prognostic factors. Ann Rheum Dis 2009, 68:1870-1877.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1870-1877
    • Westhovens, R.1    Robles, M.2    Ximenes, A.C.3    Nayiager, S.4    Wollenhaupt, J.5    Durez, P.6
  • 12
    • 84902245923 scopus 로고    scopus 로고
    • A two-step treatment strategy trial in patients with early arthritis aimed at achieving remission: the IMPROVED study
    • Heimans L., Wevers-de Boer K.V., Visser K., Goekoop R.J., van Oosterhout M., Harbers J.B., et al. A two-step treatment strategy trial in patients with early arthritis aimed at achieving remission: the IMPROVED study. Ann Rheum Dis 2014, 73:1356-1361.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1356-1361
    • Heimans, L.1    Wevers-de Boer, K.V.2    Visser, K.3    Goekoop, R.J.4    van Oosterhout, M.5    Harbers, J.B.6
  • 13
    • 10744223002 scopus 로고    scopus 로고
    • Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial
    • Klareskog L., van der Heijde D., de Jager J.P., Gough A., Kalden J., Malaise M., et al. Therapeutic effect of the combination of etanercept and methotrexate compared with each treatment alone in patients with rheumatoid arthritis: double-blind randomised controlled trial. Lancet 2004, 363:675-681.
    • (2004) Lancet , vol.363 , pp. 675-681
    • Klareskog, L.1    van der Heijde, D.2    de Jager, J.P.3    Gough, A.4    Kalden, J.5    Malaise, M.6
  • 14
    • 84893772728 scopus 로고    scopus 로고
    • EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update
    • Smolen J.S., Landewe R., Breedveld F.C., Buch M., Burmester G., Dougados M., et al. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs: 2013 update. Ann Rheum Dis 2014, 73:492-509.
    • (2014) Ann Rheum Dis , vol.73 , pp. 492-509
    • Smolen, J.S.1    Landewe, R.2    Breedveld, F.C.3    Buch, M.4    Burmester, G.5    Dougados, M.6
  • 15
    • 67549101312 scopus 로고    scopus 로고
    • Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature
    • Visser K., van der Heijde D. Optimal dosage and route of administration of methotrexate in rheumatoid arthritis: a systematic review of the literature. Ann Rheum Dis 2009, 68:1094-1099.
    • (2009) Ann Rheum Dis , vol.68 , pp. 1094-1099
    • Visser, K.1    van der Heijde, D.2
  • 16
    • 0030791403 scopus 로고    scopus 로고
    • Why intramuscular methotrexate may be more efficacious than oral dosing in patients with rheumatoid arthritis
    • Hamilton R.A., Kremer J.M. Why intramuscular methotrexate may be more efficacious than oral dosing in patients with rheumatoid arthritis. Br J Rheumatol 1997, 36:86-90.
    • (1997) Br J Rheumatol , vol.36 , pp. 86-90
    • Hamilton, R.A.1    Kremer, J.M.2
  • 17
    • 1842425908 scopus 로고    scopus 로고
    • Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis
    • Hoekstra M., Haagsma C., Neef C., et al. Bioavailability of higher dose methotrexate comparing oral and subcutaneous administration in patients with rheumatoid arthritis. J Rheumatol 2004, 31:645-648.
    • (2004) J Rheumatol , vol.31 , pp. 645-648
    • Hoekstra, M.1    Haagsma, C.2    Neef, C.3
  • 18
    • 4644275370 scopus 로고    scopus 로고
    • Better efficacy of methotrexate given by intramuscular injection than orally in patients with rheumatoid arthritis
    • Wegrzyn J., Adeleine P., Miossec P. Better efficacy of methotrexate given by intramuscular injection than orally in patients with rheumatoid arthritis. Ann Rheum Dis 2004, 63:1232-1234.
    • (2004) Ann Rheum Dis , vol.63 , pp. 1232-1234
    • Wegrzyn, J.1    Adeleine, P.2    Miossec, P.3
  • 19
    • 84903893560 scopus 로고    scopus 로고
    • Head-to-head, randomized, crossover study of oral vs subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses ≤15mg may be overcome with subcutaneous administration
    • Schiff M., Jaffe J., Freundlich B. Head-to-head, randomized, crossover study of oral vs subcutaneous methotrexate in patients with rheumatoid arthritis: drug-exposure limitations of oral methotrexate at doses ≤15mg may be overcome with subcutaneous administration. Ann Rheum Dis 2014, 73:1549-1551.
    • (2014) Ann Rheum Dis , vol.73 , pp. 1549-1551
    • Schiff, M.1    Jaffe, J.2    Freundlich, B.3
  • 20
    • 38449094689 scopus 로고    scopus 로고
    • Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis
    • Tian H., Cronstein B.N. Understanding the mechanisms of action of methotrexate: implications for the treatment of rheumatoid arthritis. Bull NYU Hosp Jt Dis 2007, 65:168-173.
    • (2007) Bull NYU Hosp Jt Dis , vol.65 , pp. 168-173
    • Tian, H.1    Cronstein, B.N.2
  • 21
    • 70350277477 scopus 로고    scopus 로고
    • Oral vs. subcutaneous low-dose methotrexate treatment in reducing gastrointestinal side effects
    • Rutkowska-Sak L., Rell-Bakalarska M., Lisowska B. Oral vs. subcutaneous low-dose methotrexate treatment in reducing gastrointestinal side effects. Reumatologia 2009, 47:207-211.
    • (2009) Reumatologia , vol.47 , pp. 207-211
    • Rutkowska-Sak, L.1    Rell-Bakalarska, M.2    Lisowska, B.3
  • 22
    • 84864570470 scopus 로고    scopus 로고
    • Canadian Rheumatology Association recommendations for pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs
    • Bykerk V.P., Akhavan P., Hazlewood G.S., Schieir O., Dooley A., Haraoui B., et al. Canadian Rheumatology Association recommendations for pharmacological management of rheumatoid arthritis with traditional and biologic disease-modifying antirheumatic drugs. J Rheumatol 2012, 39:1559-1582.
    • (2012) J Rheumatol , vol.39 , pp. 1559-1582
    • Bykerk, V.P.1    Akhavan, P.2    Hazlewood, G.S.3    Schieir, O.4    Dooley, A.5    Haraoui, B.6
  • 23
    • 0021080093 scopus 로고
    • Methotrexate therapy in rheumatoid arthritis: 15 years experience
    • Hoffmeister R.T. Methotrexate therapy in rheumatoid arthritis: 15 years experience. Am J Med 1983, 75:69-73.
    • (1983) Am J Med , vol.75 , pp. 69-73
    • Hoffmeister, R.T.1
  • 24
    • 84937725599 scopus 로고    scopus 로고
    • Update of the clinical practice guideline for the management of rheumatoid arthritis in Spain
    • Secondary Update of the clinical practice guideline for the management of rheumatoid arthritis in Spain
    • National Guideline Clearinghouse. Update of the clinical practice guideline for the management of rheumatoid arthritis in Spain. Secondary Update of the clinical practice guideline for the management of rheumatoid arthritis in Spain. 〈〉. http://www.guideline.gov/content.aspx?id=36829.
  • 25
    • 84866885065 scopus 로고    scopus 로고
    • German 2012 guidelines for the sequential medical treatment of rheumatoid arthritis. Adapted EULAR recommendations and updated treatment algorithm
    • Kruger K., Wollenhaupt J., Albrecht K., Alten R., Backhaus M., Baerwald C., et al. German 2012 guidelines for the sequential medical treatment of rheumatoid arthritis. Adapted EULAR recommendations and updated treatment algorithm. Z Rheumatol 2012, 71:592-603.
    • (2012) Z Rheumatol , vol.71 , pp. 592-603
    • Kruger, K.1    Wollenhaupt, J.2    Albrecht, K.3    Alten, R.4    Backhaus, M.5    Baerwald, C.6
  • 26
    • 45849124232 scopus 로고    scopus 로고
    • BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists
    • Chakravarty K., McDonald H., Pullar T., Taggart A., Chalmers R., Oliver S., et al. BSR/BHPR guideline for disease-modifying anti-rheumatic drug (DMARD) therapy in consultation with the British Association of Dermatologists. Rheumatology (Oxford) 2008, 47:924-925.
    • (2008) Rheumatology (Oxford) , vol.47 , pp. 924-925
    • Chakravarty, K.1    McDonald, H.2    Pullar, T.3    Taggart, A.4    Chalmers, R.5    Oliver, S.6
  • 28
    • 38149057526 scopus 로고    scopus 로고
    • Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial
    • Braun J., Kastner P., Flaxenberg P., et al. Comparison of the clinical efficacy and safety of subcutaneous versus oral administration of methotrexate in patients with active rheumatoid arthritis: results of a six-month, multicenter, randomized, double-blind, controlled, phase IV trial. Arthritis Rheum 2008, 58:73-81.
    • (2008) Arthritis Rheum , vol.58 , pp. 73-81
    • Braun, J.1    Kastner, P.2    Flaxenberg, P.3
  • 29
    • 77956055481 scopus 로고    scopus 로고
    • Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative
    • Aletaha D., Neogi T., Silman A.J., Funovits J., Felson D.T., Bingham C.O., et al. Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Arthritis Rheum 2010, 62:2569-2581.
    • (2010) Arthritis Rheum , vol.62 , pp. 2569-2581
    • Aletaha, D.1    Neogi, T.2    Silman, A.J.3    Funovits, J.4    Felson, D.T.5    Bingham, C.O.6
  • 30
    • 0028815803 scopus 로고
    • Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis
    • Prevoo M.L., van 't Hof M.A., Kuper H.H., van Leeuwen M.A., van de Putte L.B., van Riel P.L. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995, 38:44-48.
    • (1995) Arthritis Rheum , vol.38 , pp. 44-48
    • Prevoo, M.L.1    van 't Hof, M.A.2    Kuper, H.H.3    van Leeuwen, M.A.4    van de Putte, L.B.5    van Riel, P.L.6
  • 32
    • 84887935095 scopus 로고    scopus 로고
    • lmerTest: tests for random and fixed effects for linear mixed effect models (lmer objects of lme4 package)
    • R package version 1.0-2
    • Kuznetsova A, Brockhoff PB, Christensen RHB. lmerTest: tests for random and fixed effects for linear mixed effect models (lmer objects of lme4 package). R package version 1.0-2. 〈〉 2012. http://www.cran.r-project.org/package=lmerTest.
    • (2012)
    • Kuznetsova, A.1    Brockhoff, P.B.2    Christensen, R.H.B.3
  • 33
    • 84858341887 scopus 로고    scopus 로고
    • R Foundation for Statistical Computing
    • Secondary R: a language and environment for statistical computing.
    • TEAM RC. R Foundation for Statistical Computing. Secondary R: a language and environment for statistical computing. 〈〉 2013. http://www.R-project.org.
    • (2013)
  • 34
    • 84897628643 scopus 로고    scopus 로고
    • Factors associated with methotrexate dosing and therapeutic decisions in veterans with rheumatoid arthritis
    • Ng B., Chu A. Factors associated with methotrexate dosing and therapeutic decisions in veterans with rheumatoid arthritis. Clin Rheumatol 2014, 33:21-30.
    • (2014) Clin Rheumatol , vol.33 , pp. 21-30
    • Ng, B.1    Chu, A.2
  • 35
    • 84865655947 scopus 로고    scopus 로고
    • A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial
    • Moreland L.W., O'Dell J.R., Paulus H.E., Curtis J.R., Bathon J.M., Clair E.W., et al. A randomized comparative effectiveness study of oral triple therapy versus etanercept plus methotrexate in early aggressive rheumatoid arthritis: the treatment of Early Aggressive Rheumatoid Arthritis Trial. Arthritis Rheum 2012, 64:2824-2835.
    • (2012) Arthritis Rheum , vol.64 , pp. 2824-2835
    • Moreland, L.W.1    O'Dell, J.R.2    Paulus, H.E.3    Curtis, J.R.4    Bathon, J.M.5    Clair, E.W.6
  • 36
    • 68049124945 scopus 로고    scopus 로고
    • Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial
    • van Vollenhoven R.F., Ernestam S., Geborek P., Petersson I.F., Cöster L., Waltbrand E., et al. Addition of infliximab compared with addition of sulfasalazine and hydroxychloroquine to methotrexate in patients with early rheumatoid arthritis (Swefot trial): 1-year results of a randomised trial. Lancet 2009, 374:459-466.
    • (2009) Lancet , vol.374 , pp. 459-466
    • van Vollenhoven, R.F.1    Ernestam, S.2    Geborek, P.3    Petersson, I.F.4    Cöster, L.5    Waltbrand, E.6
  • 37
    • 35648991026 scopus 로고    scopus 로고
    • Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial)
    • Verstappen S.M., Jacobs J.W., van der Veen M.J., Heurkens A.H., Schenk Y., ter Borg E.J., et al. Intensive treatment with methotrexate in early rheumatoid arthritis: aiming for remission. Computer Assisted Management in Early Rheumatoid Arthritis (CAMERA, an open-label strategy trial). Ann Rheum Dis 2007, 66:1443-1449.
    • (2007) Ann Rheum Dis , vol.66 , pp. 1443-1449
    • Verstappen, S.M.1    Jacobs, J.W.2    van der Veen, M.J.3    Heurkens, A.H.4    Schenk, Y.5    Ter Borg, E.J.6
  • 38
    • 77957275016 scopus 로고    scopus 로고
    • Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study
    • Bakker M.F., Jacobs J.W., Welsing P.M., van der Werf J.H., Linn-Rasker S.P., van der Veen M.J., et al. Are switches from oral to subcutaneous methotrexate or addition of ciclosporin to methotrexate useful steps in a tight control treatment strategy for rheumatoid arthritis? A post hoc analysis of the CAMERA study. Ann Rheum Dis 2010, 69:1849-1852.
    • (2010) Ann Rheum Dis , vol.69 , pp. 1849-1852
    • Bakker, M.F.1    Jacobs, J.W.2    Welsing, P.M.3    van der Werf, J.H.4    Linn-Rasker, S.P.5    van der Veen, M.J.6
  • 39
    • 78650574250 scopus 로고    scopus 로고
    • Underestimation of the efficacy, effectiveness, tolerability, and safety of weekly low-dose methotrexate in information presented to physicians and patients
    • Pincus T., Furer V., Sokka T. Underestimation of the efficacy, effectiveness, tolerability, and safety of weekly low-dose methotrexate in information presented to physicians and patients. Clin Exp Rheumatol 2010, 28(5 Suppl 61):S68-S79.
    • (2010) Clin Exp Rheumatol , vol.28 , Issue.5 , pp. S68-S79
    • Pincus, T.1    Furer, V.2    Sokka, T.3


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