Extended Intervals after Neoadjuvant Therapy in Locally Advanced Rectal Cancer: The Key to Improved Tumor Response and Potential Organ Preservation

Journal of the American College of Surgeons

Volumn 221, Issue 2, 2015, Pages 430-440

  Probst, Christian P ^a   Becerra, Adan Z ^a   Aquina, Christopher T ^a   Tejani, Mohamedtaki A ^a   Wexner, Steven D ^b   Garcia Aguilar, Julio ^c   Remzi, Feza H ^d   Dietz, David W ^d   Monson, John R T ^a   Fleming, Fergal J ^a  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b DEPARTMENT OF COLORECTAL SURGERY   (United States)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^d LERNER RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADJUVANT CHEMORADIOTHERAPY; ADULT; ADVANCED CANCER; ARTICLE; CANCER PATIENT; CANCER STAGING; CANCER SURGERY; DISEASE ASSOCIATION; FEMALE; HOSPITAL READMISSION; HUMAN; MAJOR CLINICAL STUDY; MALE; MIDDLE AGED; ORGAN PRESERVATION; PRIORITY JOURNAL; RECTUM CANCER; RETROSPECTIVE STUDY; SURGICAL PATIENT; ADENOCARCINOMA; ADJUVANT THERAPY; AGED; COMPARATIVE STUDY; EVALUATION STUDY; FACTUAL DATABASE; MULTIVARIATE ANALYSIS; PATHOLOGY; RECTAL NEOPLASMS; RECTUM; STATISTICAL MODEL; SURGERY; TIME; TREATMENT OUTCOME;

ANTINEOPLASTIC AGENT;

ADENOCARCINOMA; ADULT; AGED; ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMORADIOTHERAPY, ADJUVANT; DATABASES, FACTUAL; FEMALE; HUMANS; LOGISTIC MODELS; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; NEOADJUVANT THERAPY; NEOPLASM STAGING; RECTAL NEOPLASMS; RECTUM; RETROSPECTIVE STUDIES; TIME FACTORS; TREATMENT OUTCOME;

EID: 84937719170     PISSN: 10727515     EISSN: 18791190     Source Type: Journal    
DOI: 10.1016/j.jamcollsurg.2015.04.010     Document Type: Article

References (34)

1. R. Siegel, D. Naishadham, and A. Jemal Cancer statistics, 2013 CA Cancer J Clin 63 2013 11 30
2. F.J. Fleming, L. Pahlman, and J.R. Monson Neoadjuvant therapy in rectal cancer Dis Colon Rectum 54 2011 901 912
3. R. Ricciardi, P.L. Roberts, T.E. Read, and et al. Who performs proctectomy for rectal cancer in the United States? Dis Colon Rectum 54 2011 1210 1215
4. K.B. Stitzenberg, H.K. Sanoff, D.C. Penn, and et al. Practice patterns and long-term survival for early-stage rectal cancer J Clin Oncol 31 2013 4276 4282
5. A.B. Benson 3rd, T. Bekaii-Saab, E. Chan, and et al. Rectal cancer J Natl Compr Canc Netw 10 2012 1528 1564
6. J.R. Monson, M.R. Weiser, W.D. Buie, and et al. Practice parameters for the management of rectal cancer (revised) Dis Colon Rectum 56 2013 535 550
7. Y. Francois, C.J. Nemoz, J. Baulieux, and et al. Influence of the interval between preoperative radiation therapy and surgery on downstaging and on the rate of sphincter-sparing surgery for rectal cancer: the Lyon R90-01 randomized trial J Clin Oncol 17 1999 2396
8. J.F. Bosset, G. Calais, L. Mineur, and et al. Enhanced tumorocidal effect of chemotherapy with preoperative radiotherapy for rectal cancer: preliminary results-EORTC 22921 J Clin Oncol 23 2005 5620 5627
9. J.P. Gerard, T. Conroy, F. Bonnetain, and et al. Preoperative radiotherapy with or without concurrent fluorouracil and leucovorin in T3-4 rectal cancers: results of FFCD 9203 J Clin Oncol 24 2006 4620 4625
10. S.T. Martin, H.M. Heneghan, and D.C. Winter Systematic review and meta-analysis of outcomes following pathological complete response to neoadjuvant chemoradiotherapy for rectal cancer Br J Surg 99 2012 918 928
11. J.D. Foster, E.L. Jones, S. Falk, and et al. Timing of surgery after long-course neoadjuvant chemoradiotherapy for rectal cancer: a systematic review of the literature Dis Colon Rectum 56 2013 921 930
12. K.Y. Bilimoria, A.K. Stewart, D.P. Winchester, and C.Y. Ko The National Cancer Data Base: a powerful initiative to improve cancer care in the United States Ann Surg Oncol 15 2008 683 690
13. Facility Oncology Registry Data Standards. https://www.facs.org/quality-programs/cancer/ncdb/registrymanuals/cocmanuals/fordsmanual. Accessed January 7, 2014.
14. M.A. Abbas, G.J. Chang, T.E. Read, and et al. Optimizing rectal cancer management: analysis of current evidence Dis Colon Rectum 57 2014 252 259
15. M.F. Kalady, L.F. de Campos-Lobato, L. Stocchi, and et al. Predictive factors of pathologic complete response after neoadjuvant chemoradiation for rectal cancer Ann Surg 250 2009 582 589
16. D.A. Sloothaak, D.E. Geijsen, N.J. van Leersum, and et al. Optimal time interval between neoadjuvant chemoradiotherapy and surgery for rectal cancer Br J Surg 100 2013 933 939
17. C.M. Dolinsky, N.N. Mahmoud, R. Mick, and et al. Effect of time interval between surgery and preoperative chemoradiotherapy with 5-fluorouracil or 5-fluorouracil and oxaliplatin on outcomes in rectal cancer J Surg Oncol 96 2007 207 212
18. M.J. Kim, J.S. Park, S.I. Park, and et al. Accuracy in differentiation of mucinous and nonmucinous rectal carcinoma on MR imaging J Computer-Assisted Tomog 27 2003 48 55
19. S.K. Yu, M. Chand, D.M. Tait, and G. Brown Magnetic resonance imaging defined mucinous rectal carcinoma is an independent imaging biomarker for poor prognosis and poor response to preoperative chemoradiotherapy Eur J Cancer 50 2014 920 927
20. L.F. de Campos-Lobato, L. Stocchi, A. da Luz Moreira, and et al. Downstaging without complete pathologic response after neoadjuvant treatment improves cancer outcomes for cIII but not cII rectal cancers Ann Surg Oncol 17 2010 1758 1766
21. J.A. Diaz-Gonzalez, F.A. Calvo, J. Cortes, and et al. Prognostic factors for disease-free survival in patients with T3-4 or N+ rectal cancer treated with preoperative chemoradiation therapy, surgery, and intraoperative irradiation Int J Radiat Oncol Biol 64 2006 1122 1128
22. G. Theodoropoulos, W.E. Wise, A. Padmanabhan, and et al. T-level downstaging and complete pathologic response after preoperative chemoradiation for advanced rectal cancer result in decreased recurrence and improved disease-free survival Dis Colon Rectum 45 2002 895 903
23. V. Valentini, C. Coco, A. Picciocchi, and et al. Does downstaging predict improved outcome after preoperative chemoradiation for extraperitoneal locally advanced rectal cancer? A long-term analysis of 165 patients Int J Radiat Oncol Biol Phys 53 2002 664 674
24. J.M. Wheeler, E. Dodds, B.F. Warren, and et al. Preoperative chemoradiotherapy and total mesorectal excision surgery for locally advanced rectal cancer: correlation with rectal cancer regression grade Dis Colon Rectum 47 2004 2025 2031
25. R.O. Perez, A. Habr-Gama, G.P. Sao Juliao, and et al. Optimal timing for assessment of tumor response to neoadjuvant chemoradiation in patients with rectal cancer: do all patients benefit from waiting longer than 6 weeks? Int J Radiat Oncol Biol Phys 84 2012 1159 1165
26. M. Maas, R.G. Beets-Tan, D.M. Lambregts, and et al. Wait-and-see policy for clinical complete responders after chemoradiation for rectal cancer J Clin Oncol 29 2011 4633 4640
27. The Stockholm III Trial on Different Preoperative Radiotherapy Regimens in Rectal Cancer. Available at: http://clinicaltrials.gov/show/NCT00904813. Accessed July 13, 2014.
28. Cancer Research United Kingdom. Treatment for rectal cancer. Available at: http://www.cancerresearchuk.org/cancer-help/trials/a-trial-looking-best-time-surgery-after-treatment-rectal-cancer. Accessed July 13, 2014.
29. STARRCAT Trial: Surgical timing after radiotherapy for rectal cancer. Available at: http://www.controlled-trials.com/ISRCTN88843062. Accessed July 13, 2014.
30. J.H. Lefevre, A. Rousseau, M. Svrcek, and et al. A multicentric randomized controlled trial on the impact of lengthening the interval between neoadjuvant radiochemotherapy and surgery on complete pathological response in rectal cancer (GRECCAR-6 trial): rationale and design BMC Cancer 13 2013 417
31. Garcia-Aguilar J, Memorial Sloan-Kettering Cancer Center. Trial evaluating 3-year disease free survival in patients with locally advanced rectal cancer treated with chemoradiation plus induction or consolidation chemotherapy and total mesorectal excision or non-operative management. In: Clinical Trials.gov. Bethesda (MD): National Library of Medicine (US); 2000. Available at: http://www.cancer.gov/clinicaltrials/search/view?cdrid=755893&version=HealthProfessional. NLM Identifier: NCT02008656. Accessed April 27, 2015.
32. A. Habr-Gama, J. Gama-Rodrigues, G.P. Sao Juliao, and et al. Local recurrence after complete clinical response and watch and wait in rectal cancer after neoadjuvant chemoradiation: impact of salvage therapy on local disease control Int J Radiat Oncol Biol Phys 88 2014 822 828
33. Schrag D. Alliance for Clinical Trials in Oncology. Chemotherapy alone or chemotherapy plus radiation therapy in treating patients with locally advanced rectal cancer undergoing surgery. In: Clinical Trials.gov. Bethesda (MD): National Library of Medicine (US);2000. Available at: http://www.cancer.gov/clinicaltrials/search/view?cdrid=715321&version=HealthProfessional. NLM Identifier: NCT01515787. Accessed April 27, 2015.
34. D. Schrag, M.R. Weiser, K.A. Goodman, and et al. Neoadjuvant chemotherapy without routine use of radiation therapy for patients with locally advanced rectal cancer: a pilot trial J Clin Oncol 32 2014 513 518