Protozoan Parasite Growth Inhibitors Discovered by Cross-Screening Yield Potent Scaffolds for Lead Discovery

Journal of Medicinal Chemistry

Volumn 58, Issue 14, 2015, Pages 5522-5537

  Devine, William ^a   Woodring, Jennifer L ^a   Swaminathan, Uma ^a   Amata, Emanuele ^a   Patel, Gautam ^a   Erath, Jessey ^b   Roncal, Norma E ^c   Lee, Patricia J ^c   Leed, Susan E ^c   Rodriguez, Ana ^b   Mensa Wilmot, Kojo ^d   Sciotti, Richard J ^c   Pollastri, Michael P ^a  

^a NORTHEASTERN UNIVERSITY   (United States)

^b NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c Walter Reed Army Institute for Research   (United States)

^d UNIVERSITY OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

4 ((3 CHLORO 4 ((3 FLUOROBENZYL)OXYPHENYL)AMINO) 6 (4 (4 METHYL 1,4 DIZEPAN 1 YL)SULFONYLPHENYL)QUINOLINE 3 CARBONITRILE; ANTIPARASITIC AGENT; ANTIPROTOZOAL AGENT; ISOQUINOLINE DERIVATIVE; LAPATINIB; N (3 CHLORO 4 ((3 FLUOROBENZYL)OXY)PHENYL) 7 (4 ((4 METHYL 1,4 DIAZEPAN 1 YL)SULFONYL)PHENYL)CINNOLIN 4 AMINE; NEU 617; NEW DRUG; QUINAZOLINE DERIVATIVE; QUINOLINE DERIVATIVE; UNCLASSIFIED DRUG; GROWTH INHIBITOR;

AFRICAN TRYPANOSOMIASIS; ANTIPROTOZOAL ACTIVITY; ARTICLE; CHAGAS DISEASE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; LEISHMANIA; LEISHMANIA MAJOR; LEISHMANIASIS; MALARIA; NONHUMAN; PARASITE; PLASMODIUM FALCIPARUM; PROTOZOAL INFECTION; PROTOZOON; SKIN LEISHMANIASIS; TROPICAL DISEASE; TRYPANOSOMA BRUCEI; TRYPANOSOMA CRUZI; ANIMAL; CHEMISTRY; DRUG DEVELOPMENT; DRUG EFFECTS; GROWTH, DEVELOPMENT AND AGING; HEPG2 CELL LINE; HUMAN;

ANIMALS; ANTIPROTOZOAL AGENTS; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; GROWTH INHIBITORS; HEP G2 CELLS; HUMANS; PARASITES; QUINAZOLINES;

EID: 84937707495     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/acs.jmedchem.5b00515     Document Type: Article

References (35)

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