Is His54 a gating residue for the ferritin ferroxidase site?

Biochimica et Biophysica Acta - Proteins and Proteomics

Volumn 1854, Issue 9, 2015, Pages 1118-1122

  Bernacchioni, Caterina ^a   Ciambellotti, Silvia ^a   Theil, Elizabeth C ^b,c   Turano, Paola ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

^b CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

^c NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

Ferritin; Ferroxidase site; Mutagenesis; Reaction kinetics

Indexed keywords

APOFERRITIN; CERULOPLASMIN; FERRIC OXIDE; FERRITIN; FERRITIN FERROXIDASE; HIS54 FERRITIN; IRON; UNCLASSIFIED DRUG; HISTIDINE;

ARTICLE; BIOMINERALIZATION; ENZYME ACTIVE SITE; FLOW KINETICS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SEQUENCE ANALYSIS; STOICHIOMETRY; BINDING SITE; CHEMISTRY; METABOLISM; X RAY CRYSTALLOGRAPHY;

RANA CATESBEIANA; VERTEBRATA;

BINDING SITES; CERULOPLASMIN; CRYSTALLOGRAPHY, X-RAY; FERRITINS; HISTIDINE; IRON;

EID: 84937642423     PISSN: 15709639     EISSN: 18781454     Source Type: Journal    
DOI: 10.1016/j.bbapap.2015.02.011     Document Type: Article

References (32)

1. E.C. Theil, R.K. Behera, and T. Tosha Ferritins for chemistry and for life Coord. Chem. Rev. 257 2013 579 586
2. R.R. Crichton, and J.P. Declercq X-ray structures of ferritins and related proteins Biochim. Biophys. Acta 1800 2010 706 718
3. D. Lalli, and P. Turano Solution and solid state NMR approaches to draw iron pathways in the ferritin nanocage Acc. Chem. Res. 46 2013 2676 2685
4. F.M. Torti, and S.V. Torti Regulation of ferritin genes and protein Blood 99 2002 3505 3516
5. P. Arosio, R. Ingrassia, and P. Cavadini Ferritins: a family of molecules for iron storage, antioxidation and more Biochim. Biophys. Acta 1790 2009 589 599
6. J.K. Schwartz, X.S. Liu, T. Tosha, E.C. Theil, and E.I. Solomon Spectroscopic definition of the ferroxidase site in M ferritin: comparison of binuclear substrate vs cofactor active sites J. Am. Chem. Soc. 130 2008 9441 9450
7. J. Hwang, C. Krebs, B.H. Huynh, D.E. Edmondson, E.C. Theil, and J.E. Penner-Hahn A short Fe-Fe distance in peroxodiferric ferritin: control of Fe substrate versus cofactor decay? Science 287 2000 122 125
8. I. Bertini, D. Lalli, S. Mangani, C. Pozzi, C. Rosa, E.C. Theil, and P. Turano Structural insights into the ferroxidase site of ferritins from higher eukaryotes J. Am. Chem. Soc. 134 2012 6169 6176
9. T. Tosha, H.L. Ng, O. Bhattasali, T. Alber, and E.C. Theil Moving metal ions through ferritin-protein nanocages from three-fold pores to catalytic sites J. Am. Chem. Soc. 132 2010 14562 14569
10. L. Toussaint, L. Bertrand, L. Hue, R.R. Crichton, and J.P. Declercq High-resolution structures of human apoferritin H-chain mutants correlated with their activity and metal-binding sites X-ray J. Mol. Biol. 365 2007 440 452
11. R.K. Behera, and E.C. Theil Moving Fe2 + from ferritin ion channels to catalytic OH centers depends on conserved protein cage carboxylates Proc. Natl. Acad. Sci. U. S. A. 111 2014 7925 7930
12. C. Pozzi, F. Di Pisa, D. Lalli, C. Rosa, E.C. Theil, P. Turano, and S. Mangani Time lapse, anomalous X-ray diffraction shows how Fe2+ substrate ions move through ferritin protein nanocages to oxidoreductase sites Acta Crystallogr. D 2015 10.1107/S1399004715002333 (in press)
13. M. Matzapetakis, P. Turano, E.C. Theil, and I. Bertini 13C-13C NOESY spectra of a 480 kDa protein: solution NMR of ferritin J. Biomol. NMR 38 2007 237 242
14. E.C. Theil, P. Turano, V. Ghini, M. Allegrozzi, and C. Bernacchioni Coordinating subdomains of ferritin protein cages with catalysis and biomineralization viewed from the C4 cage axes J. Biol. Inorg. Chem. 19 2014 615 622
15. T. Tosha, R.K. Behera, and E.C. Theil Ferritin ion channel disorder inhibits Fe(II)/O2 reactivity at distant sites Inorg. Chem. 51 2012 11406 11411
16. C. Bernacchioni, V. Ghini, C. Pozzi, F. Di Pisa, E.C. Theil, and P. Turano Loop electrostatics modulates the intersubunit interactions in ferritin ACS Chem. Biol. 21 2014 2517 2525
17. X. Liu, and E.C. Theil Ferritin reactions: direct identification of the site for the diferric peroxide reaction intermediate Proc. Natl. Acad. Sci. U. S. A. 101 2004 8557 8562
18. K.H. Ebrahimi, E. Bill, P.L. Hagedoorn, and W.R. Hagen The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement Nat. Chem. Biol. 8 2012 941 948
19. P. Turano, D. Lalli, I.C. Felli, E.C. Theil, and I. Bertini NMR reveals pathway for ferric mineral precursors to the central cavity of ferritin Proc. Natl. Acad. Sci. U. S. A. 107 2010 545 550
20. X. Liu, W. Jin, and E.C. Theil Opening protein pores with chaotropes enhances Fe reduction and chelation of Fe from the ferritin biomineral Proc. Natl. Acad. Sci. U. S. A. 100 2003 3653 3658
21. W. Jin, H. Takagi, B. Pancorbo, and E.C. Theil "Opening" the ferritin pore for iron release by mutation of conserved amino acids at interhelix and loop sites Biochemistry 40 2001 7525 7532
22. M.R. Hasan, T. Tosha, and E.C. Theil Ferritin contains less iron (59Fe) in cells when the protein pores are unfolded by mutation J. Biol. Chem. 283 2008 31394 31400
23. S. Levi, A. Luzzago, F. Franceschinelli, P. Santambrogio, G. Cesareni, and P. Arosio Mutational analysis of the channel and loop sequences of human ferritin H-chain Biochem. J. 264 1989 381 388
24. A. Treffry, E.R. Bauminger, D. Hechel, N.W. Hodson, I. Nowik, S.J. Yewdall, and P.M. Harrison Defining the roles of the threefold channels in iron uptake, iron oxidation and iron-core formation in ferritin: a study aided by site-directed mutagenesis Biochem. J. 296 1993 721 728
25. T. Takahashi, and S. Kuyucaky Functional properties of threefold and fourfold channels in ferritin deduced from electrostatic calculations Biophys. J. 84 2003 2256 2263
26. A. Marchetti, M.S. Parker, L.P. Moccia, E.O. Lin, A.L. Arrieta, F. Ribalet, M.E. Murphy, M.T. Maldonado, and E.V. Armbrust Ferritin is used for iron storage in bloom-forming marine pennate diatoms Nature 457 2009 467 470
27. K.H. Ebrahimi, E. Bill, P.L. Hagedoorn, and W.R. Hagen The catalytic center of ferritin regulates iron storage via Fe(II)-Fe(III) displacement Nat. Chem. Biol. 8 2012 941 948
28. K.H. Ebrahimi, P.L. Hagedoorn, J.A. Jongejan, and W.R. Hagen Catalysis of iron core formation in Pyrococcus furiosus ferritin J. Biol. Inorg. Chem. 14 2009 1265 1274
29. J. Tatur, W.R. Hagen, and P.M. Matias Crystal structure of the ferritin from the hyperthermophilic archaeal anaerobe Pyrococcus furiosus J. Biol. Inorg. Chem. 12 2007 615 630
30. S.K. Weeratunga, S. Lovell, H. Yao, K.P. Battaile, C.J. Fischer, C.E. Gee, and M. Rivera Structural studies of bacterioferritin B from Pseudomonas aeruginosa suggest a gating mechanism for iron uptake via the ferroxidase center Biochemistry 49 2010 1160 1175
31. A.Y. Gracey, J.V. Troll, and G.N. Somero Hypoxia-induced gene expression profiling in the euryoxic fish Gillichthys mirabilis Proc. Natl. Acad. Sci. U. S. A. 98 2001 1993 1998
32. J.M. Bradley, G.R. Moore, and N.E. Le Brun Mechanisms of iron mineralization in ferritins: one size does not fit all J. Biol. Inorg. Chem. 19 2014 775 785