메뉴 건너뛰기




Volumn 34, Issue 9, 2015, Pages 1073-1082

The transcriptional modulator BCL6 as a molecular target for breast cancer therapy

Author keywords

[No Author keywords available]

Indexed keywords

PEPTIDOMIMETIC AGENT; PROTEIN BCL 6; STAT3 PROTEIN; BCL6 PROTEIN, HUMAN; DNA BINDING PROTEIN; FEDRATINIB; PYRROLIDINE DERIVATIVE; SMALL INTERFERING RNA; SULFONAMIDE;

EID: 84937641840     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/onc.2014.61     Document Type: Article
Times cited : (69)

References (39)
  • 1
    • 0042838295 scopus 로고    scopus 로고
    • BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiaiton
    • Logarajah S, Hunter P, Kraman M, Steele D, Lakhani S, Bobrow L et al. BCL-6 is expressed in breast cancer and prevents mammary epithelial differentiaiton. Oncogene 2003;22:5572-5578.
    • (2003) Oncogene , vol.22 , pp. 5572-5578
    • Logarajah, S.1    Hunter, P.2    Kraman, M.3    Steele, D.4    Lakhani, S.5    Bobrow, L.6
  • 2
    • 33847674920 scopus 로고    scopus 로고
    • Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas
    • Polo JM, Juszczynski P, Monti S, Cerchietti L, Ye K, Greally JM et al. Transcriptional signature with differential expression of BCL6 target genes accurately identifies BCL6-dependent diffuse large B cell lymphomas. Proc Natl Acad Sci USA 2007;104:3207-3212.
    • (2007) Proc Natl Acad Sci USA , vol.104 , pp. 3207-3212
    • Polo, J.M.1    Juszczynski, P.2    Monti, S.3    Cerchietti, L.4    Ye, K.5    Greally, J.M.6
  • 3
    • 67049097382 scopus 로고    scopus 로고
    • The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL
    • Ci W, Polo JM, Cerchietti L, Shaknovich R, Wang L, Yang SN et al. The BCL6 transcriptional program features repression of multiple oncogenes in primary B cells and is deregulated in DLBCL. Blood 2009;113:5536-5548.
    • (2009) Blood , vol.113 , pp. 5536-5548
    • Ci, W.1    Polo, J.M.2    Cerchietti, L.3    Shaknovich, R.4    Wang, L.5    Yang, S.N.6
  • 5
    • 84880677334 scopus 로고    scopus 로고
    • STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6
    • Walker SR, Nelson EA, Yeh JE, Pinello L, Yuan GC, Frank DA. STAT5 outcompetes STAT3 to regulate the expression of the oncogenic transcriptional modulator BCL6. Mol Cell Biol 2013;33:2879-2890.
    • (2013) Mol Cell Biol , vol.33 , pp. 2879-2890
    • Walker, S.R.1    Nelson, E.A.2    Yeh, J.E.3    Pinello, L.4    Yuan, G.C.5    Frank, D.A.6
  • 6
    • 9144248999 scopus 로고    scopus 로고
    • Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha)
    • Bos R, Van Diest PJ, Van Der Groep P, Greijer AE, Hermsen MA, Heijnen I et al. Protein expression of B-cell lymphoma gene 6 (BCL-6) in invasive breast cancer is associated with cyclin D1 and hypoxia-inducible factor-1alpha (HIF-1alpha). Oncogene 2003;22:8948-8951.
    • (2003) Oncogene , vol.22 , pp. 8948-8951
    • Bos, R.1    Van Diest, P.J.2    Van Der Groep, P.3    Greijer, A.E.4    Hermsen, M.A.5    Heijnen, I.6
  • 7
    • 50949097945 scopus 로고    scopus 로고
    • Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells
    • Polo JM, Ci W, Licht JD, Melnick A. Reversible disruption of BCL6 repression complexes by CD40 signaling in normal and malignant B cells. Blood 2008;112:644-651.
    • (2008) Blood , vol.112 , pp. 644-651
    • Polo, J.M.1    Ci, W.2    Licht, J.D.3    Melnick, A.4
  • 8
    • 9144242434 scopus 로고    scopus 로고
    • Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain
    • Ahmad KF, Melnick A, Lax S, Bouchard D, Liu J, Kiang CL et al. Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain. Mol Cell 2003;12:1551-1564.
    • (2003) Mol Cell , vol.12 , pp. 1551-1564
    • Ahmad, K.F.1    Melnick, A.2    Lax, S.3    Bouchard, D.4    Liu, J.5    Kiang, C.L.6
  • 9
    • 11144277489 scopus 로고    scopus 로고
    • Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells
    • Polo JM, Dell'Oso T, Ranuncolo SM, Cerchietti L, Beck D, Da Silva GF et al. Specific peptide interference reveals BCL6 transcriptional and oncogenic mechanisms in B-cell lymphoma cells. Nat Med 2004;10:1329-1335.
    • (2004) Nat Med , vol.10 , pp. 1329-1335
    • Polo, J.M.1    Dell'Oso, T.2    Ranuncolo, S.M.3    Cerchietti, L.4    Beck, D.5    Da Silva, G.F.6
  • 11
    • 0032511890 scopus 로고    scopus 로고
    • The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT
    • Huynh KD, Bardwell VJ. The BCL-6 POZ domain and other POZ domains interact with the co-repressors N-CoR and SMRT. Oncogene 1998;17:2473-2484.
    • (1998) Oncogene , vol.17 , pp. 2473-2484
    • Huynh, K.D.1    Bardwell, V.J.2
  • 13
    • 34548256410 scopus 로고    scopus 로고
    • BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms
    • Parekh S, Polo JM, Shaknovich R, Juszczynski P, Lev P, Ranuncolo SM et al. BCL6 programs lymphoma cells for survival and differentiation through distinct biochemical mechanisms. Blood 2007;110:2067-2074.
    • (2007) Blood , vol.110 , pp. 2067-2074
    • Parekh, S.1    Polo, J.M.2    Shaknovich, R.3    Juszczynski, P.4    Lev, P.5    Ranuncolo, S.M.6
  • 14
    • 5344280456 scopus 로고    scopus 로고
    • MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation
    • Fujita N, Jaye DL, Geigerman C, Akyildiz A, Mooney MR, Boss JM et al. MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation. Cell 2004;119:75-86.
    • (2004) Cell , vol.119 , pp. 75-86
    • Fujita, N.1    Jaye, D.L.2    Geigerman, C.3    Akyildiz, A.4    Mooney, M.R.5    Boss, J.M.6
  • 16
    • 0037069331 scopus 로고    scopus 로고
    • Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas
    • Wang X, Li Z, Naganuma A, Ye BH. Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas. Proc Natl Acad Sci USA 2002;99:15018-15023.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15018-15023
    • Wang, X.1    Li, Z.2    Naganuma, A.3    Ye, B.H.4
  • 17
    • 65349119454 scopus 로고    scopus 로고
    • A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo
    • Cerchietti LC, Yang SN, Shaknovich R, Hatzi K, Polo JM, Chadburn A et al. A peptomimetic inhibitor of BCL6 with potent antilymphoma effects in vitro and in vivo. Blood 2009;113:3397-3405.
    • (2009) Blood , vol.113 , pp. 3397-3405
    • Cerchietti, L.C.1    Yang, S.N.2    Shaknovich, R.3    Hatzi, K.4    Polo, J.M.5    Chadburn, A.6
  • 18
    • 84859169877 scopus 로고    scopus 로고
    • The Cancer Cell Line Encyclopediaenables predictive modelling of anticancer drug sensitivity
    • Barretina J, Caponigro G, Stransky N, Venkatesan K, Margolin AA, Kim S et al. The Cancer Cell Line Encyclopediaenables predictive modelling of anticancer drug sensitivity. Nature 2012;483:603-607.
    • (2012) Nature , vol.483 , pp. 603-607
    • Barretina, J.1    Caponigro, G.2    Stransky, N.3    Venkatesan, K.4    Margolin, A.A.5    Kim, S.6
  • 19
    • 0036898253 scopus 로고    scopus 로고
    • Acetylation inactivates the transcriptional repressor BCL6
    • Bereshchenko OR, Gu W, Dalla-Favera R. Acetylation inactivates the transcriptional repressor BCL6. Nat Genet 2002;32:606-613.
    • (2002) Nat Genet , vol.32 , pp. 606-613
    • Bereshchenko, O.R.1    Gu, W.2    Dalla-Favera, R.3
  • 20
    • 33846187999 scopus 로고    scopus 로고
    • STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas
    • Walker SR, Nelson EA, Frank DA. STAT5 represses BCL6 expression by binding to a regulatory region frequently mutated in lymphomas. Oncogene 2007;26:224-233.
    • (2007) Oncogene , vol.26 , pp. 224-233
    • Walker, S.R.1    Nelson, E.A.2    Frank, D.A.3
  • 22
    • 71749089605 scopus 로고    scopus 로고
    • Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors
    • Kwon H, Thierry-Mieg D, Thierry-Mieg J, Kim H-P, Oh J, Tunyaplin C et al. Analysis of interleukin-21-induced Prdm1 gene regulation reveals functional cooperation of STAT3 and IRF4 transcription factors. Immunity 2009;31:941-952.
    • (2009) Immunity , vol.31 , pp. 941-952
    • Kwon, H.1    Thierry-Mieg, D.2    Thierry-Mieg, J.3    Kim, H.-P.4    Oh, J.5    Tunyaplin, C.6
  • 24
    • 79959956046 scopus 로고    scopus 로고
    • The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24 - Stem cell-like breast cancer cells in human tumors
    • Marotta LL, Almendro V, Marusyk A, Shipitsin M, Schemme JWalker SR et al. The JAK2/STAT3 signaling pathway is required for growth of CD44+CD24 - stem cell-like breast cancer cells in human tumors. J Clin Invest 2011;121:2723-2735.
    • (2011) J Clin Invest , vol.121 , pp. 2723-2735
    • Marotta, L.L.1    Almendro, V.2    Marusyk, A.3    Shipitsin, M.4    Schemme, J.5    Walker, R.S.6
  • 25
    • 20444446371 scopus 로고    scopus 로고
    • Identification of a genetic signature of activated signal transducer and activator of transcription3 in human tumors
    • Alvarez JV, Febbo PG, Ramaswamy S, Loda M, Richardson A, Frank DA. Identification of a genetic signature of activated signal transducer and activator of transcription3 in human tumors. Cancer Res 2005;65:5054-5062.
    • (2005) Cancer Res , vol.65 , pp. 5054-5062
    • Alvarez, J.V.1    Febbo, P.G.2    Ramaswamy, S.3    Loda, M.4    Richardson, A.5    Frank, D.A.6
  • 26
    • 58149399350 scopus 로고    scopus 로고
    • Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3
    • Nelson EA, Walker SR, Kepich A, Gashin LB, Hideshima T, Ikeda H et al. Nifuroxazide inhibits survival of multiple myeloma cells by directly inhibiting STAT3. Blood 2008;112:5095-5102.
    • (2008) Blood , vol.112 , pp. 5095-5102
    • Nelson, E.A.1    Walker, S.R.2    Kepich, A.3    Gashin, L.B.4    Hideshima, T.5    Ikeda, H.6
  • 27
    • 41249099841 scopus 로고    scopus 로고
    • Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera
    • Wernig G, Kharas MG, Okabe R, Moore SA, Leeman DS, Cullen DE et al. Efficacy of TG101348, a selective JAK2 inhibitor, in treatment of a murine model of JAK2V617F-induced polycythemia vera. Cancer Cell 2008;13:311-320.
    • (2008) Cancer Cell , vol.13 , pp. 311-320
    • Wernig, G.1    Kharas, M.G.2    Okabe, R.3    Moore, S.A.4    Leeman, D.S.5    Cullen, D.E.6
  • 28
    • 49449100990 scopus 로고    scopus 로고
    • TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients
    • Lasho TL, Tefferi A, Hood JD, Verstovsek S, Gilliland DG, Pardanani A. TG101348, a JAK2-selective antagonist, inhibits primary hematopoietic cells derived from myeloproliferative disorder patients with JAK2V617F, MPLW515K or JAK2 exon 12 mutations as well as mutation negative patients. Leukemia 2008;22:1790-1792.
    • (2008) Leukemia , vol.22 , pp. 1790-1792
    • Lasho, T.L.1    Tefferi, A.2    Hood, J.D.3    Verstovsek, S.4    Gilliland, D.G.5    Pardanani, A.6
  • 29
    • 0037453706 scopus 로고    scopus 로고
    • MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer
    • Fujita N, Jaye DL, Kajita M, Geigerman C, Moreno CS, Wade PA. MTA3, a Mi-2/NuRD complex subunit, regulates an invasive growth pathway in breast cancer. Cell 2003;113:207-219.
    • (2003) Cell , vol.113 , pp. 207-219
    • Fujita, N.1    Jaye, D.L.2    Kajita, M.3    Geigerman, C.4    Moreno, C.S.5    Wade, P.A.6
  • 30
    • 67650034863 scopus 로고    scopus 로고
    • RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1
    • Wang X, Belguise K, O'Neill CF, Sanchez-Morgan N, Romagnoli M, Eddy SF et al. RelB NF-kappaB represses estrogen receptor alpha expression via induction of the zinc finger protein Blimp1. Mol Cell Biol 2009;29:3832-3844.
    • (2009) Mol Cell Biol , vol.29 , pp. 3832-3844
    • Wang, X.1    Belguise, K.2    O'Neill, C.F.3    Sanchez-Morgan, N.4    Romagnoli, M.5    Eddy, S.F.6
  • 31
  • 32
    • 67650252530 scopus 로고    scopus 로고
    • Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery
    • Kao J, Salari K, Bocanegra M, Choi YL, Girard L, Gandhi J et al. Molecular profiling of breast cancer cell lines defines relevant tumor models and provides a resource for cancer gene discovery. PLoS One 2009;4:e6146.
    • (2009) PLoS One , vol.4 , pp. e6146
    • Kao, J.1    Salari, K.2    Bocanegra, M.3    Choi, Y.L.4    Girard, L.5    Gandhi, J.6
  • 33
    • 79960015997 scopus 로고    scopus 로고
    • Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies
    • Lehmann BD, Bauer JA, Chen X, Sanders ME, Chakravarthy AB, Shyr Y et al. Identification of human triple-negative breast cancer subtypes and preclinical models for selection of targeted therapies. J Clin Invest 2011;121:2750-2767.
    • (2011) J Clin Invest , vol.121 , pp. 2750-2767
    • Lehmann, B.D.1    Bauer, J.A.2    Chen, X.3    Sanders, M.E.4    Chakravarthy, A.B.5    Shyr, Y.6
  • 34
    • 33845209913 scopus 로고    scopus 로고
    • A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes
    • Neve RM, Chin K, Fridlyand J, Yeh J, Baehner FL, Fevr T et al. A collection of breast cancer cell lines for the study of functionally distinct cancer subtypes. Cancer Cell 2006;10:515-527.
    • (2006) Cancer Cell , vol.10 , pp. 515-527
    • Neve, R.M.1    Chin, K.2    Fridlyand, J.3    Yeh, J.4    Baehner, F.L.5    Fevr, T.6
  • 35
    • 11144241637 scopus 로고    scopus 로고
    • Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification
    • Nelson EA, Walker SR, Alvarez JV, Frank DA. Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification. J Biol Chem 2004;279:54724-54730.
    • (2004) J Biol Chem , vol.279 , pp. 54724-54730
    • Nelson, E.A.1    Walker, S.R.2    Alvarez, J.V.3    Frank, D.A.4
  • 39
    • 79959920881 scopus 로고    scopus 로고
    • An integrated ChIP-seq analysis platform with customizable workflows
    • Giannopoulou EG, Elemento O. An integrated ChIP-seq analysis platform with customizable workflows. BMC Bioinform 2011;12:277.
    • (2011) BMC Bioinform , vol.12 , pp. 277
    • Giannopoulou, E.G.1    Elemento, O.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.