TOPGEAR: A randomised phase III trial of perioperative ECF chemotherapy versus preoperative chemoradiation plus perioperative ECF chemotherapy for resectable gastric cancer (an international, intergroup trial of the AGITG/TROG/EORTC/NCIC CTG)

BMC Cancer

Volumn 15, Issue 1, 2015, Pages

  Leong, Trevor ^a   Smithers, B Mark ^b   Michael, Michael ^a   Gebski, Val ^c   Boussioutas, Alex ^a   Miller, Danielle ^c   Simes, John ^c   Zalcberg, John ^d   Haustermans, Karin ^e   Lordick, Florian ^f   Schuhmacher, Christoph ^g   Swallow, Carol ^h   Darling, Gail ⁱ   Wong, Rebecca ^j  

^a PETER MACCALLUM CANCER CENTRE   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c UNIVERSITY OF SYDNEY   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e UNIVERSITY HOSPITALS LEUVEN   (Belgium)

^f Universities of Leipzig   (Germany)

^g ECRIN   (France)

^h MOUNT SINAI HOSPITAL   (Canada)

ⁱ TORONTO GENERAL HOSPITAL   (Canada)

^j PRINCESS MARGARET HOSPITAL   (Canada)

more..

Author keywords

Adjuvant therapy; Gastric cancer; Perioperative chemotherapy; Preoperative chemoradiotherapy

Indexed keywords

CISPLATIN; EPIRUBICIN; FLUOROURACIL; ANTINEOPLASTIC AGENT;

ADULT; ARTICLE; CANCER COMBINATION CHEMOTHERAPY; CANCER SURVIVAL; CHEMORADIOTHERAPY; CLINICAL EFFECTIVENESS; CLINICAL PRACTICE; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFICACY; ECONOMIC EVALUATION; HEALTH ECONOMICS; HUMAN; INTERMETHOD COMPARISON; LOWER ESOPHAGUS SPHINCTER; MAJOR CLINICAL STUDY; MULTIPLE CYCLE TREATMENT; OUTCOME ASSESSMENT; OVERALL SURVIVAL; PATIENT SAFETY; PERIOPERATIVE PERIOD; PHASE 3 CLINICAL TRIAL; PREOPERATIVE RADIOTHERAPY; PUBLIC-PRIVATE PARTNERSHIP; QUALITY OF LIFE; RANDOMIZED CONTROLLED TRIAL; STOMACH ADENOCARCINOMA; STOMACH CANCER; ADJUVANT CHEMORADIOTHERAPY; CLINICAL TRIAL; COMPARATIVE STUDY; DRUG EFFECTS; GASTROESOPHAGEAL JUNCTION; PATHOLOGY; PREOPERATIVE CARE; PROCEDURES; RADIATION RESPONSE; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

ANTINEOPLASTIC COMBINED CHEMOTHERAPY PROTOCOLS; CHEMORADIOTHERAPY, ADJUVANT; CISPLATIN; EPIRUBICIN; ESOPHAGOGASTRIC JUNCTION; FLUOROURACIL; HUMANS; PERIOPERATIVE CARE; PREOPERATIVE CARE; STOMACH NEOPLASMS; SURVIVAL ANALYSIS; TREATMENT OUTCOME;

EID: 84937575617     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/s12885-015-1529-x     Document Type: Article

References (7)

1. Macdonald JS, Smalley SR, Benedetti J, Hundahl SA, Estes NC, Stemmermann GN, et al. Chemoradiotherapy after surgery compared with surgery alone for adenocarcinoma of the stomach or gastroesophageal junction. N Engl J Med. 2001;345:725-30.
2. Cunningham D, Allum WH, Stenning SP, Thompson JN, Van de Velde CJ, Nicolson M, et al. Perioperative chemotherapy versus surgery alone for resectable gastroesophageal cancer. N Engl J Med. 2006;355:11-20.
3. Ajani JA, Mansfield PF, Janjan N, Morris J, Pisters PW, Lynch PM, et al. Multi-institutional trial of preoperative chemoradiotherapy in patients with potentially resectable gastric carcinoma. J Clin Oncol. 2004;22:2774-80.
4. Ajani JA, Winter K, Okawara GS, Donohue JH, Pisters PW, Crane CH, et al. Phase II trial of preoperative chemoradiation in patients with localized gastric adenocarcinoma (RTOG 9904): quality of combined modality therapy and pathologic response. J Clin Oncol. 2006;24:3953-8.
5. Maruyama K, Gunven P, Okabayashi K, Sasako M, Kinoshita T. Lymph node metastases of gastric cancer. General pattern in 1931 patients. Ann Surg. 1989;210:596-602.
6. Fiorica F, Cartei F, Enea M, Licata A, Cabibbo G, Carau B, et al. The impact of radiotherapy on survival in resectable gastric carcinoma: a meta-analysis of literature data. Cancer Treat Rev. 2007;33:729-40.
7. Valentini V, Cellini F, Minsky BD, Mattiucci GC, Balducci M, D'Agostino G, et al. Survival after radiotherapy in gastric cancer: systematic review and meta-analysis. Radiother Oncol. 2009;92:176-83.