Circulating Vascular Cell Adhesion Molecule-1 Is Associated With Cerebral Blood Flow Dysregulation, Mobility Impairment, and Falls in Older Adults

Hypertension

Volumn 66, Issue 2, 2015, Pages 340-346

  Tchalla, Achille E ^a,b,c,d,e   Wellenius, Gregory A ^f   Travison, Thomas G ^a,b,c   Gagnon, Margaret ^a   Iloputaife, Ikechukwu ^g   Dantoine, Thierry ^d,e   Sorond, Farzaneh A ^a   Lipsitz, Lewis A ^a,b,c  

^a Hebrew SeniorLife Institute for Aging Research   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

^c HARVARD MEDICAL SCHOOL   (United States)

^d UNIVERSITY OF LIMOGES   (France)

^e LIMOGES UNIVERSITY HOSPITAL   (France)

^f BROWN UNIVERSITY   (United States)

^g BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Brain infarction; Endothelium; Gait; Hypertension

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 6; VASCULAR CELL ADHESION MOLECULE 1; BIOLOGICAL MARKER;

AGED; ARTICLE; BLOOD FLOW VELOCITY; BRAIN BLOOD FLOW; CEREBROVASCULAR HEMODYNAMICS; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DOPPLER ECHOGRAPHY; ENDOTHELIAL DYSFUNCTION; FALL RISK; FEMALE; GAIT; HEMODYNAMICS; HUMAN; HYPERTENSION; IMMOBILITY; INCIDENCE; MALE; MIDDLE CEREBRAL ARTERY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; WALKING SPEED; AGE; BLOOD; BLOOD FLOW; BRAIN; BRAIN CIRCULATION; COHORT ANALYSIS; FALLING; PATHOPHYSIOLOGY; PHYSIOLOGY; PROSPECTIVE STUDY; RISK FACTOR; STATISTICS AND NUMERICAL DATA; VASCULARIZATION; VERY ELDERLY; WALKING DIFFICULTY;

ACCIDENTAL FALLS; AGE FACTORS; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BRAIN; CEREBROVASCULAR CIRCULATION; COHORT STUDIES; CROSS-SECTIONAL STUDIES; FEMALE; GAIT; HUMANS; HYPERTENSION; INCIDENCE; MALE; MIDDLE CEREBRAL ARTERY; MOBILITY LIMITATION; PROSPECTIVE STUDIES; REGIONAL BLOOD FLOW; RISK FACTORS; VASCULAR CELL ADHESION MOLECULE-1;

EID: 84937557426     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/HYPERTENSIONAHA.115.05180     Document Type: Article

References (39)

1. Murray CJ, Lopez AD., Evidence-based health policy-lessons from the Global Burden of Disease Study. Science 1996;274:740-743.
2. Gorina Y, Hoyert D, Lentzner H, Goulding M., Trends in causes of death among older persons in the United States. Aging Trends 2005 1 12
3. Chen BR, Kozberg MG, Bouchard MB, Shaik MA, Hillman EM., A critical role for the vascular endothelium in functional neurovascular coupling in the brain. J Am Heart Assoc 2014 3 e000787. doi: 10.1161/JAHA.114.000787
4. Pires PW, Dams Ramos CM, Matin N, Dorrance AM., The effects of hypertension on the cerebral circulation. Am J Physiol Heart Circ Physiol 2013 304 H1598 H1614. doi: 10.1152/ajpheart.00490.2012
5. Gómez JM, Vila R, Catalina P, Soler J, Badimón L, Sahún M., The markers of inflammation and endothelial dysfunction in correlation with glycated haemoglobin are present in type 2 diabetes mellitus patients but not in their relatives. Glycoconj J 2008;25:573-579. doi: 10.1007/s10719-008-9118-8
6. Meigs JB, Hu FB, Rifai N, Manson JE., Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. JAMA 2004;291:1978-1986. doi: 10.1001/jama.291.16.1978
7. Maeda H, Matsumoto M, Handa N, Hougaku H, Ogawa S, Itoh T, Tsukamoto Y, Kamada T., Reactivity of cerebral blood flow to carbon dioxide in hypertensive patients: Evaluation by the transcranial Doppler method. J Hypertens 1994;12:191-197.
8. Hajjar I, Quach L, Yang F, Chaves PH, Newman AB, Mukamal K, Longstreth W Jr, Inzitari M, Lipsitz LA., Hypertension, white matter hyperintensities, and concurrent impairments in mobility, cognition, and mood: The Cardiovascular Health Study. Circulation 2011;123:858-865. doi: 10.1161/CIRCULATIONAHA.110.978114
9. Mulvihill NT, Foley JB, Crean P, Walsh M., Prediction of cardiovascular risk using soluble cell adhesion molecules. Eur Heart J 2002;23:1569-1574.
10. Muller WA, Weigl SA, Deng X, Phillips DM., PECAM-1 is required for transendothelial migration of leukocytes. J Exp Med 1993;178:449-460.
11. Krieglstein CF, Granger DN., Adhesion molecules and their role in vascular disease. Am J Hypertens 2001;14(6 Pt 2)44S-54S.
12. von Andrian UH, Mackay CR., T-cell function and migration. Two sides of the same coin. N Engl J Med 2000;343:1020-1034. doi: 10.1056/NEJM200010053431407
13. Leveille SG, Kiel DP, Jones RN, Roman A, Hannan MT, Sorond FA, Kang HG, Samelson EJ, Gagnon M, Freeman M, Lipsitz LA., The MOBILIZE Boston Study: Design and methods of a prospective cohort study of novel risk factors for falls in an older population. BMC Geriatr 2008;8:16. doi: 10.1186/1471-2318-8-16
14. Samelson EJ, Kelsey JL, Kiel DP, Roman AM, Cupples LA, Freeman MB, Jones RN, Hannan MT, Leveille SG, Gagnon MM, Lipsitz LA., Issues in conducting epidemiologic research among elders: Lessons from the MOBILIZE Boston Study. Am J Epidemiol 2008;168:1444-1451. doi: 10.1093/aje/kwn277
15. Folstein MF, Folstein SE, McHugh PR., "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975;12:189-198.
16. Escobar JI, Burnam A, Karno M, Forsythe A, Landsverk J, Golding JM., Use of the Mini-Mental State Examination (MMSE) in a community population of mixed ethnicity. Cultural and linguistic artifacts. J Nerv Ment Dis 1986;174:607-614.
17. Wellenius GA, Wilhelm-Benartzi CS, Wilker EH, Coull BA, Suh HH, Koutrakis P, Lipsitz LA., Ambient particulate matter and the response to orthostatic challenge in the elderly: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly (MOBILIZE) of Boston study. Hypertension 2012;59:558-563. doi: 10.1161/HYPERTENSIONAHA.111.180778
18. James PA, Oparil S, Carter BL, 2014 evidence-based guideline for the management of high blood pressure in adults: Report from the panel members appointed to the Eighth Joint National Committee (JNC 8). JAMA 2014;311:507-520. doi: 10.1001/jama.2013.284427
19. Guralnik JM, Ferrucci L, Simonsick EM, Salive ME, Wallace RB., Lower-extremity function in persons over the age of 70 years as a predictor of subsequent disability. N Engl J Med 1995;332:556-561. doi: 10.1056/NEJM199503023320902
20. Quach L, Galica AM, Jones RN, Procter-Gray E, Manor B, Hannan MT, Lipsitz LA., The nonlinear relationship between gait speed and falls: The Maintenance of Balance, Independent Living, Intellect, and Zest in the Elderly of Boston Study. J Am Geriatr Soc 2011;59:1069-1073. doi: 10.1111/j.1532-5415.2011.03408.x
21. Gibson MJ, Andres RO, Isaacs B, Radebaugh T, Wormpetersen J., The prevention of falls in later life- A report of the kellogg-international-work-group on the prevention of falls by the elderly. Dan Med Bull 1987 1 24
22. Tinetti ME, Liu WL, Claus EB., Predictors and prognosis of inability to get up after falls among elderly persons. JAMA 1993;269:65-70.
23. Sorond FA, Khavari R, Serrador JM, Lipsitz LA., Regional cerebral autoregulation during orthostatic stress: Age-related differences. J Gerontol A Biol Sci Med Sci 2005;60:1484-1487.
24. Sorond FA, Serrador JM, Jones RN, Shaffer ML, Lipsitz LA., The sit-to-stand technique for the measurement of dynamic cerebral autoregulation. Ultrasound Med Biol 2009;35:21-29. doi: 10.1016/j.ultrasmedbio.2008.08.001
25. Aaslid R, Markwalder TM, Nornes H., Noninvasive transcranial Doppler ultrasound recording of flow velocity in basal cerebral arteries. J Neurosurg 1982;57:769-774. doi: 10.3171/jns.1982.57.6.0769
26. Serrador JM, Picot PA, Rutt BK, Shoemaker JK, Bondar RL., MRI measures of middle cerebral artery diameter in conscious humans during simulated orthostasis. Stroke 2000;31:1672-1678.
27. Vorstrup S, Zbornikova V, Sjöholm H, Skoglund L, Ryding E., CBF and transcranial Doppler sonography during vasodilatory stress tests in patients with common carotid artery occlusion. Neurol Res 1992;14:31-38.
28. Washburn RA, Smith KW, Jette AM, Janney CA., The Physical Activity Scale for the Elderly (PASE): Development and evaluation. J Clin Epidemiol 1993;46:153-162.
29. Chapman DG, Nam JM., Asymptotic power of chi square tests for linear trends in proportions. Biometrics 1968;24:315-327.
30. Arcaro G, Cretti A, Balzano S, Lechi A, Muggeo M, Bonora E, Bonadonna RC., Insulin causes endothelial dysfunction in humans: Sites and mechanisms. Circulation 2002;105:576-582.
31. Novak V, Zhao P, Manor B, Sejdic E, Alsop D, Abduljalil A, Roberson PK, Munshi M, Novak P., Adhesion molecules, altered vasoreactivity, and brain atrophy in type 2 diabetes. Diabetes Care 2011;34:2438-2441. doi: 10.2337/dc11-0969
32. Purkayastha S, Fadar O, Mehregan A, Salat DH, Moscufo N, Meier DS, Guttmann CR, Fisher ND, Lipsitz LA, Sorond FA., Impaired cerebrovascular hemodynamics are associated with cerebral white matter damage. J Cereb Blood Flow Metab 2014;34:228-234. doi: 10.1038/jcbfm.2013.180
33. Sorond FA, Galica A, Serrador JM, Kiely DK, Iloputaife I, Cupples LA, Lipsitz LA., Cerebrovascular hemodynamics, gait, and falls in an elderly population: MOBILIZE Boston Study. Neurology 2010;74:1627-1633. doi: 10.1212/WNL.0b013e3181df0982
34. Cesari M, Penninx BW, Pahor M, Lauretani F, Corsi AM, Rhys Williams G, Guralnik JM, Ferrucci L., Inflammatory markers and physical performance in older persons: The InCHIANTI study. J Gerontol A Biol Sci Med Sci 2004;59:242-248.
35. Kitani A, Nakashima N, Izumihara T, Inagaki M, Baoui X, Yu S, Matsuda T, Matsuyama T., Soluble VCAM-1 induces chemotaxis of Jurkat and synovial fluid T cells bearing high affinity very late antigen-4. J Immunol 1998;161:4931-4938.
36. Touyz RM, Briones AM., Reactive oxygen species and vascular biology: Implications in human hypertension. Hypertens Res 2011;34:5-14. doi: 10.1038/hr.2010.201
37. Blankenberg S, Rupprecht HJ, Bickel C, Peetz D, Hafner G, Tiret L, Meyer J., Circulating cell adhesion molecules and death in patients with coronary artery disease. Circulation 2001;104:1336-1342.
38. Dumurgier J, Elbaz A, Dufouil C, Tavernier B, Tzourio C., Hypertension and lower walking speed in the elderly: The Three-City study. J Hypertens 2010 1506 1514
39. Lipsitz LA., A 91-year-old woman with difficult-to-control hypertension: A clinical review. JAMA 2013 1274 1280