Amelioration of Hyperbilirubinemia in Gunn Rats after Transplantation of Human Induced Pluripotent Stem Cell-Derived Hepatocytes

Stem Cell Reports

Volumn 5, Issue 1, 2015, Pages 22-30

  Chen, Yong ^a,b   Li, Yanfeng ^a,b   Wang, Xia ^a,b   Zhang, Wei ^a,b   Sauer, Vanessa ^a,b   Chang, Chan Jung ^a   Han, Bing ^c   Tchaikovskaya, Tatyana ^a,b   Avsar, Yesim ^a,b   Tafaleng, Edgar ^c   Madhusudana Girija, Sanal ^a,b   Tar, Krisztina ^a,b   Polgar, Zsuzsanna ^a,b   Strom, Stephen ^d   Bouhassira, Eric E ^a   Guha, Chandan ^a,b   Fox, Ira J ^c   Roy Chowdhury, Jayanta ^a,b   Roy Chowdhury, Namita ^a,b  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b MARION BESSIN LIVER RESEARCH CENTER   (United States)

^c CHILDREN S HOSPITAL OF PITTSBURGH   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

BILIRUBIN; BILIRUBIN GLUCURONIDE; GLUCURONOSYLTRANSFERASE 1A1; SCATTER FACTOR; GLUCURONOSYLTRANSFERASE; UGT1A1 PROTEIN, RAT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BILIARY EXCRETION; BILIRUBIN BLOOD LEVEL; BRAIN DEATH; BRAIN INJURY; CELL DIFFERENTIATION; CELL PROLIFERATION; CONTROLLED STUDY; CRIGLER NAJJAR SYNDROME TYPE I; GUNN RAT; HEPATOCYTE TRANSPLANTATION; HUMAN; HUMAN CELL; HYPERBILIRUBINEMIA; LIVER DISEASE; LIVER LOBE; NONHUMAN; NUCLEAR REPROGRAMMING; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECIPIENT; SKIN FIBROBLAST; STEM CELL TRANSPLANTATION; X IRRADIATION; ANIMAL; BIOLOGICAL THERAPY; BLOOD; CRIGLER-NAJJAR SYNDROME; DEFICIENCY; GENETICS; INDUCED PLURIPOTENT STEM CELL; LIVER; LIVER CELL; PATHOLOGY; SURGERY; TRANSPLANTATION;

RATTUS NORVEGICUS;

ANIMALS; BILIRUBIN; CELL- AND TISSUE-BASED THERAPY; CRIGLER-NAJJAR SYNDROME; GLUCURONOSYLTRANSFERASE; HEPATOCYTES; HUMANS; HYPERBILIRUBINEMIA; INDUCED PLURIPOTENT STEM CELLS; LIVER; RATS; RATS, GUNN;

EID: 84937526410     PISSN: 22136711     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.stemcr.2015.04.017     Document Type: Article

References (28)

1. F. Åberg, H. Isoniemi, and K. Höckerstedt Long-term results of liver transplantation Scand. J. Surg. 100 2011 14 21
2. H. Basma, A. Soto-Gutiérrez, G.R. Yannam, L. Liu, R. Ito, T. Yamamoto, E. Ellis, S.D. Carson, S. Sato, Y. Chen, and et al. Differentiation and transplantation of human embryonic stem cell-derived hepatocytes Gastroenterology 136 2009 990 999
3. S.L. Bick, D.P. Bick, B.E. Wells, M.R. Roesler, E.Y. Strawn, and E.C. Lau Preimplantation HLA haplotyping using tri-, tetra-, and pentanucleotide short tandem repeats for HLA matching J. Assist. Reprod. Genet. 25 2008 323 331
4. P.J. Bosma, N.R. Chowdhury, B.G. Goldhoorn, M.H. Hofker, R.P.J. Oude Elferink, P.L.M. Jansen, and J.R. Chowdhury Sequence of exons and the flanking regions of human bilirubin-UDP-glucuronosyltransferase gene complex and identification of a genetic mutation in a patient with Crigler-Najjar syndrome, type I Hepatology 15 1992 941 947
5. J. Cai, Y. Zhao, Y. Liu, F. Ye, Z. Song, H. Qin, S. Meng, Y. Chen, R. Zhou, X. Song, and et al. Directed differentiation of human embryonic stem cells into functional hepatic cells Hepatology 45 2007 1229 1239
6. A. Carpentier, A. Tesfaye, V. Chu, I. Nimgaonkar, F. Zhang, S.B. Lee, S.S. Thorgeirsson, S.M. Feinstone, and T.J. Liang Engrafted human stem cell-derived hepatocytes establish an infectious HCV murine model J. Clin. Invest. 124 2014 4953 4964
7. L.A. Dawson, and R.K. Ten Haken Partial volume tolerance of the liver to radiation Semin. Radiat. Oncol. 15 2005 279 283
8. Y. Duan, X. Ma, W. Zou, C. Wang, I.S. Bahbahan, T.P. Ahuja, V. Tolstikov, and M.A. Zern Differentiation and characterization of metabolically functioning hepatocytes from human embryonic stem cells Stem Cells 28 2010 674 686
9. R.A. Fisher, and S.C. Strom Human hepatocyte transplantation: worldwide results Transplantation 82 2006 441 449
10. I.J. Fox, J.R. Chowdhury, S.S. Kaufman, T.C. Goertzen, N.R. Chowdhury, P.I. Warkentin, K. Dorko, B.V. Sauter, and S.C. Strom Treatment of the Crigler-Najjar syndrome type I with hepatocyte transplantation N. Engl. J. Med. 338 1998 1422 1426
11. C. Guha, B. Parashar, N.J. Deb, M. Garg, G.R. Gorla, A. Singh, N. Roy-Chowdhury, B. Vikram, and J. Roy-Chowdhury Normal hepatocytes correct serum bilirubin after repopulation of Gunn rat liver subjected to irradiation/partial resection Hepatology 36 2002 354 362
12. N. Lavon, O. Yanuka, and N. Benvenisty Differentiation and isolation of hepatic-like cells from human embryonic stem cells Differentiation 72 2004 230 238
13. H. Liu, Y. Kim, S. Sharkis, L. Marchionni, and Y.-Y. Jang In vivo liver regeneration potential of human induced pluripotent stem cells from diverse origins Sci. Transl. Med. 3 2011 82ra39
14. P.A. Lysy, M. Najimi, X. Stéphenne, A. Bourgois, F. Smets, and E.M. Sokal Liver cell transplantation for Crigler-Najjar syndrome type I: update and perspectives World J. Gastroenterol. 14 2008 3464 3470
15. N. O'Callaghan, V. Dhillon, P. Thomas, and M. Fenech A quantitative real-time PCR method for absolute telomere length Biotechniques 44 2008 807 809
16. G.B. Odell "Physiologic" hyperbilirubinemia in the neonatal period N. Engl. J. Med. 277 1967 193 195
17. F. Ozçay, F. Alehan, S. Sevmiş, H. Karakayali, G. Moray, A. Torgay, G. Arslan, and M. Haberal Living related liver transplantation in Crigler-Najjar syndrome type 1 Transplant. Proc. 41 2009 2875 2877
18. J. Roy-Chowdhury, T.J. Huang, K. Kesari, M. Lederstein, I.M. Arias, and N. Roy-Chowdhury Molecular basis for the lack of bilirubin-specific and 3-methylcholanthrene-inducible UDP-glucuronosyltransferase activities in Gunn rats. The two isoforms are encoded by distinct mRNA species that share an identical single base deletion J. Biol. Chem. 266 1991 18294 18298
19. N. Roy-Chowdhury, R. Kondapalli, and J. Roy-Chowdhury The Gunn rat: an animal model for inherited deficiency of bilirubin glucuronidation C.E. Cornelius, Animal Models in Liver Research 1993 Academic Press 149 171
20. J. Roy-Chowdhury, N. Roy-Chowdhury, S. Horslen, and I.J. Fox Experimental Therapies: Hepatocytes transplantation, gene therapy, and liver assist devices T. Yamada, Text Book of Gastroenterology 2009 Wiley-Blackwell 2432 2448
21. R.E. Schwartz, J.L. Linehan, M.S. Painschab, W.S. Hu, C.M. Verfaillie, and D.S. Kaufman Defined conditions for development of functional hepatic cells from human embryonic stem cells Stem Cells Dev. 14 2005 643 655
22. K. Si-Tayeb, F.K. Noto, M. Nagaoka, J. Li, M.A. Battle, C. Duris, P.E. North, S. Dalton, and S.A. Duncan Highly efficient generation of human hepatocyte-like cells from induced pluripotent stem cells Hepatology 51 2010 297 305
23. Z. Song, J. Cai, Y. Liu, D. Zhao, J. Yong, S. Duo, X. Song, Y. Guo, Y. Zhao, H. Qin, and et al. Efficient generation of hepatocyte-like cells from human induced pluripotent stem cells Cell Res. 19 2009 1233 1242
24. K. Takahashi, and S. Yamanaka Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors Cell 126 2006 663 676
25. K. Yamanouchi, H. Zhou, N. Roy-Chowdhury, F. Macaluso, L. Liu, T. Yamamoto, G.R. Yannam, C. Enke, T.D. Solberg, A.B. Adelson, and et al. Hepatic irradiation augments engraftment of donor cells following hepatocyte transplantation Hepatology 49 2009 258 267
26. Y. Yoshida, and S. Yamanaka iPS cells: a source of cardiac regeneration J. Mol. Cell. Cardiol. 50 2011 327 332
27. J. Yu, M.A. Vodyanik, K. Smuga-Otto, J. Antosiewicz-Bourget, J.L. Frane, S. Tian, J. Nie, G.A. Jonsdottir, V. Ruotti, R. Stewart, and et al. Induced pluripotent stem cell lines derived from human somatic cells Science 318 2007 1917 1920
28. H. Zhou, X. Dong, R. Kabarriti, Y. Chen, Y. Avsar, X. Wang, J. Ding, L. Liu, I.J. Fox, J. Roy-Chowdhury, and et al. Single liver lobe repopulation with wildtype hepatocytes using regional hepatic irradiation cures jaundice in Gunn rats PLoS ONE 7 2012 e46775