Identification and quantitation of 5-fluoro-ADB-PINACA and MAB-CHMINACA in dubious herbal products

Forensic Toxicology

Volumn 33, Issue 2, 2015, Pages 213-220

  Wurita, Amin ^a   Hasegawa, Koutaro ^a   Minakata, Kayoko ^a   Gonmori, Kunio ^a   Nozawa, Hideki ^a   Yamagishi, Itaru ^a   Watanabe, Kanako ^a   Suzuki, Osamu ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

5 Fluoro AB PINACA; 5 Fluoro ADB PINACA; AB CHMINACA; Herbal products; LC MS MS; MAB CHMINACA; Synthetic cannabinoid

Indexed keywords

5 FLUORO AB PINACA; 5 FLUORO ADB PINACA; AB CHMINACA; AMIDE; CANNABINOID; GM SAPPHIRE; HERBACEOUS AGENT; HERBAL BLEND EXTRACT; INDAZOLE CARBOXAMIDE; MAB CHMINACA; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL ANALYSIS; DRUG SCREENING; HUMAN; HUMAN TISSUE; LABORATORY TEST; LIQUID CHROMATOGRAPHY; MASS FRAGMENTOGRAPHY; MASS SPECTROMETRY; POLICE; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; STANDARD; TANDEM MASS SPECTROMETRY;

EID: 84937526340     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-015-0264-y     Document Type: Article

References (15)

1. Uchiyama N, Matsuda S, Wakana D, Kikura-Hanajiri R, Goda Y (2013) New cannabimimetic indazole derivatives, N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-pentyl-1H-indazole-3-carboxamide (AB-PINACA) and N-(1-amino-3-methyl-1-oxobutan-2-yl)-1-(4-fluorobenzyl)-1H-indazole-3- carboxamide (AB-FUBINACA) identified as designer drugs in illegal products. Forensic Toxicol 31:93–100
2. Uchiyama N, Matsuda S, Kawamura M, Kikura-Hanajiri R, Goda Y (2013) Two new-type cannabimimetic quinolinyl carboxylates, QUPIC and QUCHIC, two new cannabimimetic carboxamide derivatives, ADB-FUBINACA and ADBICA, and five synthetic cannabinoids detected with a thiophene derivative α-PVT and an opioid receptor agonist AH-7921 identified in illegal products. Forensic Toxicol 31:223–240
3. Uchiyama N, Shimokawa Y, Kawamura M, Kikura-Hanajiri R, Hakamatsuka T (2014) Chemical analysis of a benzofuran derivative, 2-(2-ethylaminopropyl)benzofuran (2-EAPB), eight synthetic cannabinoids, five cathinone derivatives, and five other designer drugs newly detected in illegal products. Forensic Toxicol 32:266–281
4. Hasegawa K, Wurita A, Minakata K, Gonmori K, Yamagishi I, Nozawa H, Watanabe K, Suzuki O (2015) Identification and quantitation of 5-fluoro-ADB, one of the most dangerous synthetic cannabinoids, in the stomach contents, and solid tissues of a human cadaver, and in some herbal products. Forensic Toxicol 33:112–121
5. Cayman Chemical (2014) Cayman spectral library. https://www.caymanchem.com/app/template/SpectralLibrary.vm. Accessed Oct 2014
6. Minakata K, Yamagishi I, Nozawa H, Hasegawa K, Wurita A, Gonmori K, Suzuki M, Watanabe K, Suzuki O (2014) MALDI-TOF mass spectrometric determination of four pyrrolidino cathinones in human blood. Forensic Toxicol 32:169–175
7. Wurita A, Hasegawa K, Minakata K, Watanabe K, Suzuki O (2014) A large amount of new designer drug diphenidine coexisting with a synthetic cannabinoid 5-fluoro-AB-PINACA found in a dubious herbal product. Forensic Toxicol 32:331–337
8. Tsujikawa K, Yamamuro T, Kuwayama K, Kanamori T, Iwata YT, Inoue H (2014) Thermal degradation of a new synthetic cannabinoid QUPIC during analysis by gas chromatography–mass spectrometry. Forensic Toxicol 32:201–207
9. Bonilla E (1978) Flameless atomic absorption spectrophotometric determination of manganese in rat brain and other tissues. Clin Chem 24:471–474
10. Wurita A, Suzuki O, Hasegawa K, Gonmori K, Minakata K, Yamagishi I, Nozawa H, Watanabe K (2013) Sensitive determination of ethylene glycol, propylene glycol and diethylene glycol in human whole blood by isotope dilution gas chromatography–mass spectrometry, and the presence of appreciable amounts of the glycols in blood of healthy subjects. Forensic Toxicol 31:272–280
11. Wurita A, Suzuki O, Hasegawa K, Gonmori K, Minakata K, Yamagishi I, Nozawa H, Watanabe K (2014) Presence of appreciable amounts of ethylene glycol, propylene glycol, and diethylene glycol in human urine of healthy subjects. Forensic Toxicol 32:39–44
12. Wurita A, Suzuki O, Hasegawa K, Gonmori K, Minakata K, Yamagishi I, Nozawa H, Watanabe K (2014) Occurrence of postmortem production of ethylene glycol and propylene glycol in human specimens. Forensic Toxicol 32:162–168
13. Hasegawa K, Suzuki O, Wurita A, Minakata K, Yamagishi I, Nozawa H, Gonmori K, Watanabe K (2014) Postmortem distribution of α-pyrrolidinovalerophenone and its metabolite in body fluids and solid tissues in a fatal poisoning case measured by LC–MS–MS with the standard addition method. Forensic Toxicol 32:225–234
14. Hasegawa K, Wurita A, Minakata K, Gonmori K, Nozawa H, Yamagishi I, Suzuki O, Watanabe K (2014) Identification and quantitation of a new cathinone designer drug PV9 in an “aroma liquid” product, antemortem whole blood and urine specimens, and a postmortem whole blood specimen in its fatal poisoning case. Forensic Toxicol 32:243–250
15. Wurita A, Hasegawa K, Minakata K, Gonmori K, Nozawa H, Yamagishi I, Suzuki O, Watanabe K (2014) Postmortem distribution of α-pyrrolidinobutiophenone in body fluids and solid tissues of a human cadaver. Leg Med 16:241–246