Sensitive determination of ethylene glycol, propylene glycol and diethylene glycol in human whole blood by isotope dilution gas chromatography-mass spectrometry, and the presence of appreciable amounts of the glycols in blood of healthy subjects

Forensic Toxicology

Volumn 31, Issue 2, 2013, Pages 272-280

  Wurita, Amin ^a   Suzuki, Osamu ^a   Hasegawa, Koutaro ^a   Gonmori, Kunio ^a   Minakata, Kayoko ^a   Yamagishi, Itaru ^a   Nozawa, Hideki ^a   Watanabe, Kanako ^a  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Diethylene glycol; Ethylene glycol; GC MS; Glycols in blood of healthy subjects; Propylene glycol; Stable isotope dilution

Indexed keywords

ACID ANHYDRIDE; DIETHYLENE GLYCOL; ETHYLENE GLYCOL; GLYCOL; HEXANE; PERFLUOROBUTYRIC ANHYDRIDE; PROPYLENE GLYCOL; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; BLOOD LEVEL; BLOOD SAMPLING; CALIBRATION; CENTRIFUGATION; CONCENTRATION (PARAMETERS); ENERGY DRINK; FEMALE; HUMAN; HUMAN EXPERIMENT; LIMIT OF DETECTION; LIMIT OF QUANTITATION; MALE; MASS FRAGMENTOGRAPHY; MEASUREMENT REPEATABILITY; NORMAL HUMAN; PRIORITY JOURNAL; SIGNAL NOISE RATIO;

EID: 84879793606     PISSN: 18608965     EISSN: 18608973     Source Type: Journal    
DOI: 10.1007/s11419-013-0188-3     Document Type: Article

References (20)

1. Baselt RC (2004) Disposition of toxic drugs and chemicals in man. 7th edn. Biomedical Publications, Foster, pp 332-333, 425-428, 960-961
2. Barr DB, Barr JR, Weerasekera G, Wamsley J, Kalb SR, Sjödin A, Schier JG, Rentz ED, Lewis L, Rubin C, Needham LL, Jones RL, Sampson EJ (2007) Identification and quantification of diethylene glycol in pharmaceuticals implicated in poisoning epidemics: a historical laboratory perspective. J Anal Toxicol 31:295-303
3. Pomara C, Fiore C, D'Errico S, Riezzo I, Fineschi V (2008) Calcium oxalate crystals in acute ethylene glycol poisoning: a confocal laser scanning microscope study in a fatal case. Clin Toxical 46:322-324
4. Pillai U, Hothi JC, Bhat ZY (2012) Severe propylene glycol toxicity secondary to use of anti-epileptics. Am J Ther. doi: 10.1097/MJT. 0b013e31824c407d
5. Houzé P, Chaussard J, Harry P, Pays M (1993) Simultaneous determination of ethylene glycol, propylene glycol, 1,3-butylene glycol and 2,3-butylene glycol in human serum and urine by wide-bore column gas chromatography. J Chromatogr 619:251-257
6. Williams RH, Shah SM, Maggiore JA, Erickson TB (2000) Simultaneous detection and quantitation of diethylene glycol, ethylene glycol, and the toxic alcohols in serum using capillary column gas chromatography. J Anal Toxicol 24:621-626
7. Dasgupta A, Blackwell W, Griego J, Malik S (1995) Gas chromatographic-mass spectrometric identification and quantitation of ethylene glycol in serum after derivatization with perfluorooctanoyl chloride: a novel derivative. J Chromatogr B 666:63-70
8. Raksit A, Punani S (1997) Gas chromatographic-mass spectrometric investigation of aliphatic glycols in environmental samples. J Chromatogr Sci 35:489-494
9. Zabetakis I, Gramshaw JW (1998) 1,2-Propanediol in strawberries and its role as a flavour precursor. Food Chem 61:351-354
10. Porter WH, Rutter PW, Yao HH (1999) Simultaneous determination of ethylene glycol and glycolic acid in serum by gas chromatography-mass spectrometry. J Anal Toxicol 23:591-597
11. Maurer HH, Peters FT, Paul LD, Kraemer T (2001) Validated gas chromatographic-mass spectrometric assay for determination of antifreezes ethylene glycol and diethylene glycol in human plasma after microwave-Assisted pivalylation. J Chromatogr B 754:401-409
12. Gembus V, Goullé J-P, Lacroix C (2002) Determination of glycols in biological specimens by gas chromatography-mass spectrometry. J Anal Toxicol 26:280-285
13. Van Hee P, Neels H, De Doncker M, Vrydags N, Schatteman K, Uyttenbroeck W, Hamers N, Himpe D, Lambert W (2004) Analysis of γ-hydroxybutyric acid, dl-lactic acid, glycolic acid, ethylene glycol and other glycols in body fluids by a direct injection gas chromatography-mass spectrometry assay for wide use. Clin Chem Lab Med 42:1341-1345
14. Zhu J, Feng Y-L, Aikawa B (2004) A positive chemical ionization GC/MS method for the determination of airborne ethylene glycol and propylene glycols in non-occupational environments. J Environ Monit 6:881-887
15. Rasanen I, Viinamäki J, Vuori E, Ojanperä I (2010) Headspace in-tube extraction gas chromatography-mass spectrometry for the analysis of hydroxylic methyl-derivatized and volatile organic compounds in blood and urine. J Anal Toxicol 34:113-121
16. Meyer MR, Weber AA, Maurer HH (2011) A validated GC-MS procedure for fast, simple, and cost-effective quantification of glycols and GHB in human plasma and their identification in urine and plasma developed for emergency toxicology. Anal Bioanal Chem 400:411-414
17. Holčapek M, Virelizier H, Chamot-Rooke J, Jandera P, Moulin C (1999) Trace determination of glycols by HPLC with UV and electrospray ionization mass spectrometric detections. Anal Chem 71:2288-2293
18. Cappiello A, Famiglini G, Palma P, Termopoli V, Trufelli H, Di Mento R, Mannozzi M (2009) LC-ESI-MS determination of diethylene glycol pollution in sea water samples collected around gas extraction platform plants. Talanta 80:257-262
19. Schier JG, Barr DB, Li Z, Wolkin AF, Baker SE, Lewis LS, McGeehin MA (2011) Diethylene glycol in health products sold over-the-counter and imported from Asian countries. J Med Toxicol 7:33-38
20. Namera A, Nakamoto A, Saito T, Nagao M (2011) Colorimetric detection and chromatographic analyses of designer drugs in biological materials: a comprehensive review. Forensic Toxicol 29:1-24