T-cell clonality assessment by next-generation sequencing improves detection sensitivity in mycosis fungoides

Journal of the American Academy of Dermatology

Volumn 73, Issue 2, 2015, Pages 228-236.e2

  Sufficool, Kari E ^a   Lockwood, Christina M ^a   Abel, Haley J ^a   Hagemann, Ian S ^a   Schumacher, Jonathan A ^b   Kelley, Todd W ^c   Duncavage, Eric J ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b ARUP LABORATORIES   (United States)

^c UNIVERSITY OF UTAH SCHOOL OF MEDICINE   (United States)

Author keywords

cutaneous T cell lymphoma; molecular diagnostics; mycosis fungoides; next generation sequencing; T cell clonality; T cell receptor rearrangement

Indexed keywords

GENOMIC DNA; T LYMPHOCYTE RECEPTOR GAMMA CHAIN; DNA; LYMPHOCYTE ANTIGEN RECEPTOR;

ADULT; AGED; ANALYTICAL EQUIPMENT; ARTICLE; CANCER DIAGNOSIS; CANCER LOCALIZATION; CANCER RECURRENCE; CANCER STAGING; CAPILLARY ELECTROPHORESIS; CLINICAL ARTICLE; CLONAL VARIATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DNA EXTRACTION; FEMALE; FOLLOW UP; GENE REARRANGEMENT; GOLD STANDARD; HUMAN; HUMAN CELL; HUMAN TISSUE; INTERMETHOD COMPARISON; MALE; MOLECULAR DIAGNOSTICS; MYCOSIS FUNGOIDES; NEXT GENERATION SEQUENCING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SENSITIVITY AND SPECIFICITY; SKIN BIOPSY; T LYMPHOCYTE; TUMOR BIOPSY; ELECTROPHORESIS; FACTUAL DATABASE; GENETIC PREDISPOSITION; GENETICS; MIDDLE AGED; MOLECULAR CLONING; MOLECULAR GENETICS; PATHOLOGY; PROCEDURES; PROGNOSIS; RETROSPECTIVE STUDY; SKIN NEOPLASMS; TUMOR RECURRENCE;

ADULT; AGED; CLONING, MOLECULAR; DATABASES, FACTUAL; DNA, NEOPLASM; ELECTROPHORESIS; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; MYCOSIS FUNGOIDES; NEOPLASM RECURRENCE, LOCAL; POLYMERASE CHAIN REACTION; PROGNOSIS; RECEPTORS, ANTIGEN, T-CELL; RETROSPECTIVE STUDIES; SKIN NEOPLASMS;

EID: 84937524463     PISSN: 01909622     EISSN: 10976787     Source Type: Journal    
DOI: 10.1016/j.jaad.2015.04.030     Document Type: Article

References (35)

1. G. Strutton Cutaneous infiltrates-lymphomatous and leukemic D. Weedon, Weedon's skin pathology 3rd ed. 2010 Churchill Livingstone Elsevier London 973 978
2. K. Korgavkar, M. Xiong, and M. Weinstock Changing incidence trends of cutaneous T-cell lymphoma JAMA Dermatol 149 11 2013 1295 1299
3. P.T. Bradford, S.S. Devesa, W.F. Anderson, and J.R. Toro Cutaneous lymphoma incidence patterns in the United States: a population-based study of 3884 cases Blood 113 2009 5064 5073
4. M. Girardi, P.W. Heald, and L.D. Wilson The pathogenesis of mycosis fungoides N Engl J Med 350 2004 1978 1988
5. R. Willemze, E.S. Jaffe, G. Burg, and et al. WHO-EORTC classification for cutaneous lymphomas Blood 105 2005 3768 3785
6. E. Ralfkiaer, L. Cerroni, C.A. Sander, B.R. Smoller, and R. Willemze Mycosis fungoides S.H. Swerdlow, E. Campo, N.L. Harris, E.S. Jaffe, S.A. Pileri, H. Stein, WHO classification of tumors of hematopoietic and lymphoid tissues 2007 International Agency for Research on Cancer (IARC) Lyon 296 298
7. L. Kandolf Sekulović, B. Cikota, O. Stojadinović, and et al. TCR γ-gene rearrangement analysis in skin samples and peripheral blood of mycosis fungoides patients Acta Dermatovenerol APA 16 2007 149
8. B.R. Smoller, K. Bishop, E. Glusac, Y.H. Kim, and M. Hendrickson Reassessment of histologic parameters in the diagnosis of mycosis fungoides Am J Surg Pathol 19 1995 1423 1430
9. J.L. Sanchez, and A.B. Ackerman The patch stage of mycosis fungoides: criteria for histologic diagnosis Am J Dermatopathol 1 1979 5 26
10. N. Pimpinelli, E.A. Olsen, M. Santucci, and et al. Defining early mycosis fungoides Am J Dermatopathol 53 2005 1053 1063
11. C. Massone, K. Kodama, H. Kerl, and L. Cerroni Histopathologic feature of early (patch) lesions of mycosis fungoides: a morphologic study on 745 biopsy specimens from 427 patients Am J Surg Pathol 29 2005 550 560
12. M. Santucci, A. Biggeri, A.C. Feller, and G. Burg Accuracy, concordance, and reproducibility of histologic diagnosis in cutaneous T-cell lymphoma: and EORTC cutaneous lymphoma project group study. European Organization for Research and Treatment of Cancer Arch Dermatol 135 2000 497 502
13. M. Santucci, A. Biggeri, A.C. Feller, D. Massi, and G. Berg Efficacy of histologic criteria for diagnosis early mycosis fungoides: an EORTC cutaneous lymphoma study group investigation. European Organization for Research and Treatment of Cancer Am J Surg Pathol 24 2000 40 50
14. K. Nasu, J. Said, E. Vonderheid, J. Olerud, D. Sako, and M. Kadin Immunopathology of cutaneous T-cell lymphomas Am J Pathol 119 1985 436 437
15. B.F. Haynes, L.L. Hensely, and B.V. Jegasothy Phenotypic characterization of skin-infiltrating T-cells in cutaneous T-cell lymphoma: comparison with benign cutaneous T-cell infiltrates Blood 60 1982 263 273
16. C.M. Payne, T.M. Grogan, and P.J. Lynch An ultrastructural morphometric and immunohistochemical analysis of cutaneous lymphomas and benign lymphocytic infiltrates of skin. Useful criteria for diagnosis Arch Dermatol 122 1986 1139 1154
17. E. Ralfkiaer, T.A. Saati, J. Bosq, G. Delsol, K.C. Gatter, and D.Y. Mason Immunocytochemical characterization of cutaneous lymphomas other than mycosis fungoides J Clin Pathol 39 1986 553 563
18. A. Ormsby, W.F. Bergfeld, R.R. Tubbs, and E.D. Hsi Evaluation of a new paraffin-reactive CD7 T-cell deletion marker and a polymerase chain reaction-based T-cell receptor gene rearrangement assay: implications for diagnosis of mycosis fungoides in community clinical practice J Am Acad Dermatol 45 2001 405 413
19. S.A. Ismail, R. Han, S.L. Sanborn, and et al. Immunohistochemical stain of CD45R isoforms in paraffin sections to diagnose mycosis fungoides-type cutaneous T-cell lymphoma J Am Acad Dermatol 56 2007 635 642
20. S.I. Jawed, P.L. Myskowsk, S. Horwitz, A. Moskowitz, and C. Querfeld Primary cutaneous T-cell lymphoma (mycosis fungoides and Sézary syndrome) Part I. Diagnosis: clinical and histopathologic features and new molecular and biologic markers J Am Acad Dermatol 70 2 2014 205.e1 205.e16
21. R. Ponti, M.T. Fierro, P. Quaglino, and et al. TCRγ-chain rearrangement by PCR-based GeneScan: diagnostic accuracy improvement and clonal heterogeneity analysis in multiple cutaneous T-cell lymphoma samples J Invest Dermatol 128 2008 1030 1038
22. G.S. Wood T-cell receptor and immunoglobulin gene rearrangements in diagnosing skin disease Arch Dermatol 173 2001 1503 1506
23. A.K. Abbas, and A.H. Lichtman Cellular and molecular immunology 2003 Elsevier Saunders Philadelphia (PA)
24. G.S. Wood, R.M. Tung, A.C. Haeffner, and et al. Detection of clonal T-cell receptor γ gene rearrangements in early mycosis fungoides/Sézary syndrome by polymerase chain reaction and denaturing gradient gel electrophoresis (PCR/DGGE) J Invest Dermatol 103 1994 34 41
25. T.C. Greiner, and R.J. Rubocki Effectiveness of capillary electrophoresis using fluorescent-labeled primers in detecting T-cell receptor gamma gene rearrangements J Mol Diagn 4 3 2002 137 143
26. J.H. van Krieken, A.W. Langerak, E.A. Macintyre, and et al. Improved reliability of lymphoma diagnosis via PCR-based clonality testing: report of the BIOMED-2 concerted action BHM4-CT98-3936 Leukemia 21 2007 201 206
27. P. Chitgopeker, and D. Sahni T-cell receptor gene rearrangement detection in suspected cases of cutaneous T-cell lymphoma J Invest Dermatol 134 2014 1 5
28. A.W. Langerak, P.J. Groenen, M. Brüggemann, and et al. EuroClonality/BIOMED-2 guidelines for interpretation and reporting of Ig/TCR clonality testing in suspected lymphoproliferations Leukemia 26 2012 2159 2171
29. J.A. Schumacher, E.J. Duncavage, T.L. Mosbruger, P.M. Szankasi, and T.W. Kelley A comparison of deep sequencing of TCRG rearrangements vs traditional capillary electrophoresis for assessment of clonality in T-cell lymphoproliferative disorders Am J Clin Pathol 141 2014 348 359
30. L.C. Lawnicki, R.J. Rubocki, W.C. Chan, D.M. Lytle, and T.C. Greiner The distribution of gene segments in T-cell receptor gamma gene rearrangements demonstrates the need for multiple primer sets J Mol Diagn 5 2003 82 87
31. Aronesty E. ea-utils: Command-line tools for processing biological sequencing data. Available from: http://code.google.com/p/ea-utils. Accessed May 26, 2015.
32. Hannonlab. FASTX-Toolkit. Available from: http://hannonlab.cshl.edu/fastx-toolkit/index.html. Accessed May 26, 2015.
33. Lefranc, M.-P. ImmunoGenetics/IMGT database. Available from: http://www.imgt.org/. Accessed May 26, 2015.
34. D. Wu, A. Sherwood, J.R. Fromm, and et al. High-throughput sequencing detects minimal residual disease in acute T lymphoblastic leukemia Sci Transl Med 4 2012 134ra63
35. S.E. Thurber, B. Zhang, Y.H. Kim, I. Schrijver, J. Zehnder, and S. Kohler T-cell clonality analysis in biopsy specimens from two different skin sites shows high specificity in the diagnosis of patients with suggested mycosis fungoides J Am Acad Dermatol 57 2007 782 790