Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis: A retrospective study

The Lancet Neurology

Volumn 13, Issue 2, 2014, Pages 167-177

  Gresa Arribas, Nuria ^a   Titulaer, Maarten J ^a,b   Torrents, Abiguei ^a   Aguilar, Esther ^a   McCracken, Lindsey ^d   Leypoldt, Frank ^a   Gleichman, Amy J ^c,e   Balice Gordon, Rita ^d   Rosenfeld, Myrna R ^a,d   Lynch, David ^d,e   Graus, Francesc ^a   Dalmau, Josep ^a,d,f  

^a HOSPITAL CLÍNIC   (Spain)

^b ERASMUS MEDICAL CENTER   (Netherlands)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e CHILDREN S HOSPITAL OF PHILADELPHIA   (United States)

^f INSTITUCIÓ CATALANA DE RECERCA I ESTUDIS AVANÇATS ICREA   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

EPITOPE; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; N METHYL DEXTRO ASPARTIC ACID RECEPTOR ANTIBODY; RECEPTOR ANTIBODY; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ANTI N METHYL D ASPARTATE RECEPTOR ENCEPHALITIS; ANTIBODY BLOOD LEVEL; ANTIBODY TITER; ARTICLE; CELL ASSAY; CEREBROSPINAL FLUID LEVEL; CLINICAL ASSESSMENT; CLINICAL TRIAL (TOPIC); CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; DILUTION; FOLLOW UP; HUMAN; HUMAN TISSUE; IMMUNOASSAY; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MUTANT; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; RANKIN SCALE; RAT; RELAPSE; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY; SYSTEMATIC REVIEW (TOPIC); TERATOMA;

ANIMALS; ANTI-N-METHYL-D-ASPARTATE RECEPTOR ENCEPHALITIS; AUTOANTIBODIES; BRAIN; CELL LINE; DISEASE PROGRESSION; HUMANS; MUTATION; RATS; RECEPTORS, N-METHYL-D-ASPARTATE; RECURRENCE; RETROSPECTIVE STUDIES; TERATOMA;

EID: 84892504348     PISSN: 14744422     EISSN: 14744465     Source Type: Journal    
DOI: 10.1016/S1474-4422(13)70282-5     Document Type: Article

References (40)

1. Dalmau J, Gleichman AJ, Hughes EG, et al. Anti-NMDA-receptor encephalitis: case series and analysis of the effects of antibodies. Lancet Neurol 2008, 7:1091-1098.
2. Gleichman AJ, Spruce LA, Dalmau J, Seeholzer SH, Lynch DR Anti-NMDA Receptor encephalitis antibody binding is dependent on amino acid identity of a small region within the GluN1 amino terminal domain. J Neurosci 2012, 32:11082-11094.
3. Kumakura A, Miyajima T, Fujii T, Takahashi Y, Ito M A patient with epilepsia partialis continua with anti-glutamate receptor epsilon 2 antibodies. Pediatr Neurol 2003, 29:160-163.
4. Takahashi Y, Mori H, Mishina M, et al. Autoantibodies and cell-mediated autoimmunity to NMDA-type GluRepsilon2 in patients with Rasmussen's encephalitis and chronic progressive epilepsia partialis continua. Epilepsia 2005, 46(suppl 5):152-158.
5. DeGiorgio LA, Konstantinov KN, Lee SC, Hardin JA, Volpe BT, Diamond B A subset of lupus anti-DNA antibodies cross-reacts with the NR2 glutamate receptor in systemic lupus erythematosus. Nat Med 2001, 7:1189-1193.
6. Hughes EG, Peng X, Gleichman AJ, et al. Cellular and synaptic mechanisms of anti-NMDA receptor encephalitis. J Neurosci 2010, 30:5866-5875.
7. Dalmau J, Tuzun E, Wu HY, et al. Paraneoplastic anti-N-methyl-D-aspartate receptor encephalitis associated with ovarian teratoma. Ann Neurol 2007, 61:25-36.
8. Sansing LH, Tuzun E, Ko MW, Baccon J, Lynch DR, Dalmau J A patient with encephalitis associated with NMDA receptor antibodies. Nat Clin Pract Neurol 2007, 3:291-296.
9. Pruss H, Dalmau J, Harms L, et al. Retrospective analysis of NMDA receptor antibodies in encephalitis of unknown origin. Neurology 2010, 75:1735-1739.
10. Greiner H, Leach JL, Lee KH, Krueger DA Anti-NMDA receptor encephalitis presenting with imaging findings and clinical features mimicking Rasmussen syndrome. Seizure 2011, 20:266-270.
11. Punja M, Pomerleau AC, Devlin JJ, Morgan BW, Schier JG, Schwartz MD Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis: an etiology worth considering in the differential diagnosis of delirium. Clin Toxicol (Phila) 2013, 51:794-797.
12. Suh-Lailam BB, Haven TR, Copple SS, Knapp D, Jaskowski TD, Tebo AE Anti-NMDA-receptor antibody encephalitis: performance evaluation and laboratory experience with the anti-NMDA-receptor IgG assay. Clin Chim Acta 2013, 421:1-6.
13. Irani SR, Bera K, Waters P, et al. N-methyl-D-aspartate antibody encephalitis: temporal progression of clinical and paraclinical observations in a predominantly non-paraneoplastic disorder of both sexes. Brain 2010, 133:1655-1667.
14. Vincent A, Bien CG, Irani SR, Waters P Autoantibodies associated with diseases of the CNS: new developments and future challenges. Lancet Neurol 2011, 10:759-772.
15. Zandi MS, Irani SR, Lang B, et al. Disease-relevant autoantibodies in first episode schizophrenia. J Neurol 2011, 258:686-688.
16. Mackay G, Ahmad K, Stone J, et al. NMDA receptor autoantibodies in sporadic Creutzfeldt-Jakob disease. J Neurol 2012, 259:1979-1981.
17. Deakin J, Lennox BR, Zandi MS Antibodies to the N-Methyl-D-Aspartate receptor and other synaptic proteins in psychosis. Biol Psychiatry 2013, published online Aug 26. 10.1016/j.biopsych.2013.07.018.
18. Hammer MS, Larsen MB, Stack CV Outcome of children with opsoclonus-myoclonus regardless of etiology. Pediatr Neurol 1995, 13:21-24.
19. Masdeu JC, Gonzalez-Pinto A, Matute C, et al. Serum IgG antibodies against the NR1 subunit of the NMDA receptor not detected in schizophrenia. Am J Psychiatry 2012, 169:1120-1121.
20. Grau-Rivera O, Sánchez-Valle R, Saiz A, et al. Determination of neuronal antibodies in suspected and definite Creutzfeldt-Jakob disease. JAMA Neurol 2013, published online Nov 18. 10.1001/jamaneurol.2013.4857.
21. Titulaer MJ, McCracken L, Gabilondo I, et al. Treatment and prognostic factors for long-term outcome in patients with anti-NMDA receptor encephalitis: an observational cohort study. Lancet Neurol 2013, 12:157-165.
22. Vincent A, Bien CG Anti-NMDA-receptor encephalitis: a cause of psychiatric, seizure, and movement disorders in young adults. Lancet Neurol 2008, 7:1074-1075.
23. Furneaux HF, Reich L, Posner JB Autoantibody synthesis in the central nervous system of patients with paraneoplastic syndromes. Neurology 1990, 40:1085-1091.
24. Thomas A, Rauschkolb P, Gresa-Arribas N, Schned A, Dalmau J, Fadul CE Anti-N-methyl-D-aspartate receptor encephalitis: a patient with refractory illness after 25 months of intensive immunotherapy. JAMA Neurol 2013, published online Oct 28. 10.1001/jamaneurol.2013.3205.
25. Alexopoulos H, Kosmidis ML, Dalmau J, Dalakas MC Paraneoplastic anti-NMDAR encephalitis: long term follow-up reveals persistent serum antibodies. J Neurol 2011, 258:1568-1570.
26. Hansen HC, Klingbeil C, Dalmau J, Li W, Weissbrich B, Wandinger KP Persistent intrathecal antibody synthesis 15 years after recovering from anti- N-methyl-D-aspartate receptor encephalitis. JAMA Neurol 2013, 70:117-119.
27. Dalmau J, Lancaster E, Martinez-Hernandez E, Rosenfeld MR, Balice-Gordon R Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis. Lancet Neurol 2011, 10:63-74.
28. van Swieten JC, Koudstaal PJ, Visser MC, Schouten HJ, van Gijn J Interobserver agreement for the assessment of handicap in stroke patients. Stroke 1988, 19:604-607.
29. Verbeke G, Molenberghs G Linear mixed models for longitudinal data 2010, Springer-Verlag, New York.
30. Hammer C, Stepniak B, Schneider A, et al. Neuropsychiatric disease relevance of circulating anti-NMDA receptor autoantibodies depends on blood-brain barrier integrity. Mol Psychiatry 2013, published online Sept 3. 10.1038/mp.2013.110.
31. Viaccoz A, Desestret V, Ducray F, et al. Clinical specificities of adult male patients with NMDA receptor antibodies encephalitis. Neurology (in press).
32. Steiner J, Walter M, Glanz W, et al. Increased prevalence of diverse N-methyl-D-aspartate glutamate receptor antibodies in patients with an initial diagnosis of schizophrenia: specific relevance of IgG NR1a antibodies for distinction from N-methyl-D-aspartate glutamate receptor encephalitis. JAMA Psychiatry 2013, 70:271-278.
33. Kayser MS, Titulaer MJ, Gresa-Arribas N, Dalmau J Frequency and characteristics of isolated psychiatric episodes in anti-N-methyl-d-aspartate receptor encephalitis. JAMA Neurol 2013, 70:1133-1139.
34. Titulaer M J, Dalmau J. Seizures as first symptom of anti-NMDA receptor encephalitis are more common in men. Neurology (in press).
35. Armangue T, Titulaer MJ, Malaga I, et al. Pediatric anti-N-methyl-D-aspartate receptor encephalitis-clinical analysis and novel findings in a series of 20 patients. J Pediatr 2013, 162:850-856.
36. Leypoldt F, Titulaer FJ, Aguilar E, et al. Herpes simplex virus-1 encephalitis can trigger anti-NMDA receptor encephalitis: case report. Neurology 2013, 81:1637-1639.
37. Hacohen Y, Deiva K, Pettingill P, et al. N-methyl-D-aspartate receptor antibodies in post herpes simplex virus encephalitis neurological relapse. Mov Disord 2013, published online Sept 6. 10.1002/mds.25626.
38. Mohammad SS, Sinclair K, Pillai S, et al. Herpes simplex encephalitis relapse with chorea is associated with autoantibodies to N-methyl-D-aspartate receptor or dopamine-2-receptor. Mov Disord 2013, published online Oct 1. 10.1002/mds.25623.
39. Armangue T, Leypoldt F, Málaga I, et al. Herpes simplex virus encephalitis is a trigger of brain autoimmunity. Ann Neurol 2013, published online Dec 8. 10.1002/ana.24083.
40. Iizuka T, Sakai F, Ide T, et al. Anti-NMDA receptor encephalitis in Japan: long-term outcome without tumor removal. Neurology 2008, 70:504-511.