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Volumn 52, Issue 3, 2015, Pages 200-206

Acute myelogenous leukemia and its microenvironment: A Molecular conversation

Author keywords

[No Author keywords available]

Indexed keywords

ALDEHYDE DEHYDROGENASE; ANGIOPOIETIN; ANGIOPOIETIN RECEPTOR; BETA1 INTEGRIN; BEVACIZUMAB; BGB 324; CD18 ANTIGEN; CEDIRANIB; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; CYTARABINE; DICER; FIBROBLAST GROWTH FACTOR 2; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; GROWTH ARREST SPECIFIC PROTEIN 6; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 10; LENALIDOMIDE; MITOXANTRONE; POMALIDOMIDE; RETINOIC ACID; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN;

EID: 84937434287     PISSN: 00371963     EISSN: 15328686     Source Type: Journal    
DOI: 10.1053/j.seminhematol.2015.03.003     Document Type: Review
Times cited : (25)

References (58)
  • 1
    • 33751267902 scopus 로고    scopus 로고
    • Acute myeloid leukaemia
    • Estey E., Dohner H. Acute myeloid leukaemia. Lancet 2006, 368:1894-1907.
    • (2006) Lancet , vol.368 , pp. 1894-1907
    • Estey, E.1    Dohner, H.2
  • 2
    • 84859854912 scopus 로고    scopus 로고
    • A clinically relevant population of leukemic CD34(+)CD38(-) cells in acute myeloid leukemia
    • Gerber J.M., Smith B.D., Ngwang B., et al. A clinically relevant population of leukemic CD34(+)CD38(-) cells in acute myeloid leukemia. Blood 2012, 119:3571-3577.
    • (2012) Blood , vol.119 , pp. 3571-3577
    • Gerber, J.M.1    Smith, B.D.2    Ngwang, B.3
  • 3
    • 0028091194 scopus 로고
    • A cell initiating human acute myeloid leukaemia after transplantation into SCID mice
    • Lapidot T., Sirard C., Vormoor J., et al. A cell initiating human acute myeloid leukaemia after transplantation into SCID mice. Nature 1994, 367:645-648.
    • (1994) Nature , vol.367 , pp. 645-648
    • Lapidot, T.1    Sirard, C.2    Vormoor, J.3
  • 4
    • 84855412217 scopus 로고    scopus 로고
    • Concise review: cancer stem cells and minimal residual disease
    • Ghiaur G., Gerber J., Jones R.J. Concise review: cancer stem cells and minimal residual disease. Stem cells 2012, 30:89-93.
    • (2012) Stem cells , vol.30 , pp. 89-93
    • Ghiaur, G.1    Gerber, J.2    Jones, R.J.3
  • 5
    • 84897132895 scopus 로고    scopus 로고
    • Nice neighborhood: emerging concepts of the stem cell niche
    • Scadden D.T. Nice neighborhood: emerging concepts of the stem cell niche. Cell 2014, 157:41-50.
    • (2014) Cell , vol.157 , pp. 41-50
    • Scadden, D.T.1
  • 6
    • 0018102359 scopus 로고
    • The relationship between the spleen colony-forming cell and the haemopoietic stem cell
    • Schofield R. The relationship between the spleen colony-forming cell and the haemopoietic stem cell. Blood Cells 1978, 4:7-25.
    • (1978) Blood Cells , vol.4 , pp. 7-25
    • Schofield, R.1
  • 7
    • 33845540617 scopus 로고    scopus 로고
    • Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice
    • Ninomiya M., Abe A., Katsumi A., et al. Homing, proliferation and survival sites of human leukemia cells in vivo in immunodeficient mice. Leukemia 2007, 21:136-142.
    • (2007) Leukemia , vol.21 , pp. 136-142
    • Ninomiya, M.1    Abe, A.2    Katsumi, A.3
  • 8
    • 84907422946 scopus 로고    scopus 로고
    • Osteoblasts protect AML cells from SDF-1-induced apoptosis
    • Kremer K.N., Dudakovic A., McGee-Lawrence M.E., et al. Osteoblasts protect AML cells from SDF-1-induced apoptosis. J Cell Biochem 2014, 115:1128-1137.
    • (2014) J Cell Biochem , vol.115 , pp. 1128-1137
    • Kremer, K.N.1    Dudakovic, A.2    McGee-Lawrence, M.E.3
  • 9
    • 84908587480 scopus 로고    scopus 로고
    • Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts
    • Krevvata M., Silva B.C., Manavalan J.S., et al. Inhibition of leukemia cell engraftment and disease progression in mice by osteoblasts. Blood 2014, 124:2834-2846.
    • (2014) Blood , vol.124 , pp. 2834-2846
    • Krevvata, M.1    Silva, B.C.2    Manavalan, J.S.3
  • 10
    • 84884164883 scopus 로고    scopus 로고
    • Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche
    • Schepers K., Pietras E.M., Reynaud D., et al. Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche. Cell Stem Cell 2013, 13:285-299.
    • (2013) Cell Stem Cell , vol.13 , pp. 285-299
    • Schepers, K.1    Pietras, E.M.2    Reynaud, D.3
  • 11
    • 84905741878 scopus 로고    scopus 로고
    • Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche
    • Hanoun M., Zhang D., Mizoguchi T., et al. Acute myelogenous leukemia-induced sympathetic neuropathy promotes malignancy in an altered hematopoietic stem cell niche. Cell Stem Cell 2014, 15:365-375.
    • (2014) Cell Stem Cell , vol.15 , pp. 365-375
    • Hanoun, M.1    Zhang, D.2    Mizoguchi, T.3
  • 12
    • 84887424411 scopus 로고    scopus 로고
    • Differential regulation of myeloid leukemias by the bone marrow microenvironment
    • Krause D.S., Fulzele K., Catic A., et al. Differential regulation of myeloid leukemias by the bone marrow microenvironment. Nat Med 2013, 19:1513-1517.
    • (2013) Nat Med , vol.19 , pp. 1513-1517
    • Krause, D.S.1    Fulzele, K.2    Catic, A.3
  • 13
    • 84893917461 scopus 로고    scopus 로고
    • Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts
    • Kode A., Manavalan J.S., Mosialou I., et al. Leukaemogenesis induced by an activating beta-catenin mutation in osteoblasts. Nature 2014, 506:240-244.
    • (2014) Nature , vol.506 , pp. 240-244
    • Kode, A.1    Manavalan, J.S.2    Mosialou, I.3
  • 14
    • 77950862042 scopus 로고    scopus 로고
    • Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia
    • Raaijmakers M.H., Mukherjee S., Guo S., et al. Bone progenitor dysfunction induces myelodysplasia and secondary leukaemia. Nature 2010, 464:852-857.
    • (2010) Nature , vol.464 , pp. 852-857
    • Raaijmakers, M.H.1    Mukherjee, S.2    Guo, S.3
  • 15
    • 0034655595 scopus 로고    scopus 로고
    • Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia
    • Padro T., Ruiz S., Bieker R., et al. Increased angiogenesis in the bone marrow of patients with acute myeloid leukemia. Blood 2000, 95:2637-2644.
    • (2000) Blood , vol.95 , pp. 2637-2644
    • Padro, T.1    Ruiz, S.2    Bieker, R.3
  • 16
    • 0035877993 scopus 로고    scopus 로고
    • Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid
    • Kini A.R., Peterson L.A., Tallman M.S., Lingen M.W. Angiogenesis in acute promyelocytic leukemia: induction by vascular endothelial growth factor and inhibition by all-trans retinoic acid. Blood 2001, 97:3919-3924.
    • (2001) Blood , vol.97 , pp. 3919-3924
    • Kini, A.R.1    Peterson, L.A.2    Tallman, M.S.3    Lingen, M.W.4
  • 17
    • 0033957420 scopus 로고    scopus 로고
    • Evidence of increased angiogenesis in patients with acute myeloid leukemia
    • Hussong J.W., Rodgers G.M., Shami P.J. Evidence of increased angiogenesis in patients with acute myeloid leukemia. Blood 2000, 95:309-313.
    • (2000) Blood , vol.95 , pp. 309-313
    • Hussong, J.W.1    Rodgers, G.M.2    Shami, P.J.3
  • 18
    • 2542643823 scopus 로고    scopus 로고
    • Bone marrow microvessel density and its prognostic significance in AML
    • Rabitsch W., Sperr W.R., Lechner K., et al. Bone marrow microvessel density and its prognostic significance in AML. Leuk Lymphoma 2004, 45:1369-1373.
    • (2004) Leuk Lymphoma , vol.45 , pp. 1369-1373
    • Rabitsch, W.1    Sperr, W.R.2    Lechner, K.3
  • 19
    • 0033885493 scopus 로고    scopus 로고
    • Increased bone marrow angiogenesis in B cell chronic lymphocytic leukemia
    • Kini A.R., Kay N.E., Peterson L.C. Increased bone marrow angiogenesis in B cell chronic lymphocytic leukemia. Leukemia 2000, 14:1414-1418.
    • (2000) Leukemia , vol.14 , pp. 1414-1418
    • Kini, A.R.1    Kay, N.E.2    Peterson, L.C.3
  • 20
    • 0033485961 scopus 로고    scopus 로고
    • Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia
    • Aguayo A., Estey E., Kantarjian H., et al. Cellular vascular endothelial growth factor is a predictor of outcome in patients with acute myeloid leukemia. Blood 1999, 94:3717-3721.
    • (1999) Blood , vol.94 , pp. 3717-3721
    • Aguayo, A.1    Estey, E.2    Kantarjian, H.3
  • 21
    • 2542547507 scopus 로고    scopus 로고
    • Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: therapy with sequential 1-beta-d-arabinofuranosylcytosine, mitoxantrone, and bevacizumab
    • Karp J.E., Gojo I., Pili R., et al. Targeting vascular endothelial growth factor for relapsed and refractory adult acute myelogenous leukemias: therapy with sequential 1-beta-d-arabinofuranosylcytosine, mitoxantrone, and bevacizumab. Clin Cancer Res 2004, 10:3577-3585.
    • (2004) Clin Cancer Res , vol.10 , pp. 3577-3585
    • Karp, J.E.1    Gojo, I.2    Pili, R.3
  • 22
    • 84921733102 scopus 로고    scopus 로고
    • Functional integration of acute myeloid leukemia into the vascular niche
    • Cogle C.R., Goldman D.C., Madlambayan G.J., et al. Functional integration of acute myeloid leukemia into the vascular niche. Leukemia 2014, 28:1978-1987.
    • (2014) Leukemia , vol.28 , pp. 1978-1987
    • Cogle, C.R.1    Goldman, D.C.2    Madlambayan, G.J.3
  • 23
    • 57649104690 scopus 로고    scopus 로고
    • Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators
    • Hatfield K., Oyan A.M., Ersvaer E., et al. Primary human acute myeloid leukaemia cells increase the proliferation of microvascular endothelial cells through the release of soluble mediators. Br J Haematol 2009, 144:53-68.
    • (2009) Br J Haematol , vol.144 , pp. 53-68
    • Hatfield, K.1    Oyan, A.M.2    Ersvaer, E.3
  • 24
    • 20044371963 scopus 로고    scopus 로고
    • Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival
    • Loges S., Heil G., Bruweleit M., et al. Analysis of concerted expression of angiogenic growth factors in acute myeloid leukemia: expression of angiopoietin-2 represents an independent prognostic factor for overall survival. J Clin Oncol 2005, 23:1109-1117.
    • (2005) J Clin Oncol , vol.23 , pp. 1109-1117
    • Loges, S.1    Heil, G.2    Bruweleit, M.3
  • 25
    • 67149133738 scopus 로고    scopus 로고
    • The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome
    • Sozer S., Fiel M.I., Schiano T., Xu M., Mascarenhas J., Hoffman R. The presence of JAK2V617F mutation in the liver endothelial cells of patients with Budd-Chiari syndrome. Blood 2009, 113:5246-5249.
    • (2009) Blood , vol.113 , pp. 5246-5249
    • Sozer, S.1    Fiel, M.I.2    Schiano, T.3    Xu, M.4    Mascarenhas, J.5    Hoffman, R.6
  • 26
    • 84887743438 scopus 로고    scopus 로고
    • Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma
    • Ben-Batalla I., Schultze A., Wroblewski M., et al. Axl, a prognostic and therapeutic target in acute myeloid leukemia mediates paracrine crosstalk of leukemia cells with bone marrow stroma. Blood 2013, 122:2443-2452.
    • (2013) Blood , vol.122 , pp. 2443-2452
    • Ben-Batalla, I.1    Schultze, A.2    Wroblewski, M.3
  • 27
    • 84902086753 scopus 로고    scopus 로고
    • GAS6 expression identifies high-risk adult AML patients: potential implications for therapy
    • Whitman S.P., Kohlschmidt J., Maharry K., et al. GAS6 expression identifies high-risk adult AML patients: potential implications for therapy. Leukemia 2014, 28:1252-1258.
    • (2014) Leukemia , vol.28 , pp. 1252-1258
    • Whitman, S.P.1    Kohlschmidt, J.2    Maharry, K.3
  • 28
    • 84877611775 scopus 로고    scopus 로고
    • Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target
    • Park I.K., Mishra A., Chandler J., Whitman S.P., Marcucci G., Caligiuri M.A. Inhibition of the receptor tyrosine kinase Axl impedes activation of the FLT3 internal tandem duplication in human acute myeloid leukemia: implications for Axl as a potential therapeutic target. Blood 2013, 121:2064-2073.
    • (2013) Blood , vol.121 , pp. 2064-2073
    • Park, I.K.1    Mishra, A.2    Chandler, J.3    Whitman, S.P.4    Marcucci, G.5    Caligiuri, M.A.6
  • 29
    • 84888000018 scopus 로고    scopus 로고
    • Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia
    • Lee-Sherick A.B., Eisenman K.M., Sather S., et al. Aberrant Mer receptor tyrosine kinase expression contributes to leukemogenesis in acute myeloid leukemia. Oncogene 2013, 32:5359-5368.
    • (2013) Oncogene , vol.32 , pp. 5359-5368
    • Lee-Sherick, A.B.1    Eisenman, K.M.2    Sather, S.3
  • 30
    • 84924425611 scopus 로고    scopus 로고
    • An engineered Axl decoy receptor effectively silences the Gas6-Axl signaling axis
    • Kariolis M.S., Miao Y.R., Jones D.S., et al. An engineered Axl 'decoy receptor' effectively silences the Gas6-Axl signaling axis. Nat Cehm Biol 2014, 10(11):977-983.
    • (2014) Nat Cehm Biol , vol.10 , Issue.11 , pp. 977-983
    • Kariolis, M.S.1    Miao, Y.R.2    Jones, D.S.3
  • 31
    • 0027358691 scopus 로고
    • Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms
    • Bendall L.J., Kortlepel K., Gottlieb D.J. Human acute myeloid leukemia cells bind to bone marrow stroma via a combination of beta-1 and beta-2 integrin mechanisms. Blood 1993, 82:3125-3132.
    • (1993) Blood , vol.82 , pp. 3125-3132
    • Bendall, L.J.1    Kortlepel, K.2    Gottlieb, D.J.3
  • 32
    • 10644243397 scopus 로고    scopus 로고
    • In vitro crosstalk between fibroblasts and native human acute myelogenous leukemia (AML) blasts via local cytokine networks results in increased proliferation and decreased apoptosis of AML cells as well as increased levels of proangiogenic Interleukin 8
    • Ryningen A., Wergeland L., Glenjen N., Gjertsen B.T., Bruserud O. In vitro crosstalk between fibroblasts and native human acute myelogenous leukemia (AML) blasts via local cytokine networks results in increased proliferation and decreased apoptosis of AML cells as well as increased levels of proangiogenic Interleukin 8. Leuk Res 2005, 29:185-196.
    • (2005) Leuk Res , vol.29 , pp. 185-196
    • Ryningen, A.1    Wergeland, L.2    Glenjen, N.3    Gjertsen, B.T.4    Bruserud, O.5
  • 33
    • 78650695157 scopus 로고    scopus 로고
    • The crosstalk between the matrix metalloprotease system and the chemokine network in acute myeloid leukemia
    • Hatfield K.J., Reikvam H., Bruserud O. The crosstalk between the matrix metalloprotease system and the chemokine network in acute myeloid leukemia. Curr Med Chem 2010, 17:4448-4461.
    • (2010) Curr Med Chem , vol.17 , pp. 4448-4461
    • Hatfield, K.J.1    Reikvam, H.2    Bruserud, O.3
  • 34
    • 81555196340 scopus 로고    scopus 로고
    • Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts
    • Blau O., Baldus C.D., Hofmann W.K., et al. Mesenchymal stromal cells of myelodysplastic syndrome and acute myeloid leukemia patients have distinct genetic abnormalities compared with leukemic blasts. Blood 2011, 118:5583-5592.
    • (2011) Blood , vol.118 , pp. 5583-5592
    • Blau, O.1    Baldus, C.D.2    Hofmann, W.K.3
  • 35
    • 84871090517 scopus 로고    scopus 로고
    • Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms
    • Kobune M., Iyama S., Kikuchi S., et al. Stromal cells expressing hedgehog-interacting protein regulate the proliferation of myeloid neoplasms. Blood Cancer J 2012, 2:e87.
    • (2012) Blood Cancer J , vol.2
    • Kobune, M.1    Iyama, S.2    Kikuchi, S.3
  • 36
    • 84902106468 scopus 로고    scopus 로고
    • Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-kappaB mediates chemoresistance
    • Jacamo R., Chen Y., Wang Z., et al. Reciprocal leukemia-stroma VCAM-1/VLA-4-dependent activation of NF-kappaB mediates chemoresistance. Blood 2014, 123:2691-2702.
    • (2014) Blood , vol.123 , pp. 2691-2702
    • Jacamo, R.1    Chen, Y.2    Wang, Z.3
  • 37
    • 0036738149 scopus 로고    scopus 로고
    • Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins
    • Konopleva M., Konoplev S., Hu W., Zaritskey A.Y., Afanasiev B.V., Andreeff M. Stromal cells prevent apoptosis of AML cells by up-regulation of anti-apoptotic proteins. Leukemia 2002, 16:1713-1724.
    • (2002) Leukemia , vol.16 , pp. 1713-1724
    • Konopleva, M.1    Konoplev, S.2    Hu, W.3    Zaritskey, A.Y.4    Afanasiev, B.V.5    Andreeff, M.6
  • 38
    • 80755132158 scopus 로고    scopus 로고
    • Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells
    • Despeaux M., Labat E., Gadelorge M., et al. Critical features of FAK-expressing AML bone marrow microenvironment through leukemia stem cell hijacking of mesenchymal stromal cells. Leukemia 2011, 25:1789-1793.
    • (2011) Leukemia , vol.25 , pp. 1789-1793
    • Despeaux, M.1    Labat, E.2    Gadelorge, M.3
  • 39
    • 34250331610 scopus 로고    scopus 로고
    • A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency
    • Walkley C.R., Olsen G.H., Dworkin S., et al. A microenvironment-induced myeloproliferative syndrome caused by retinoic acid receptor gamma deficiency. Cell 2007, 129:1097-1110.
    • (2007) Cell , vol.129 , pp. 1097-1110
    • Walkley, C.R.1    Olsen, G.H.2    Dworkin, S.3
  • 40
    • 84885071003 scopus 로고    scopus 로고
    • Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling
    • Ghiaur G., Yegnasubramanian S., Perkins B., Gucwa J.L., Gerber J.M., Jones R.J. Regulation of human hematopoietic stem cell self-renewal by the microenvironment's control of retinoic acid signaling. Proc Natl Acad Sci U S A 2013, 110:16121-16126.
    • (2013) Proc Natl Acad Sci U S A , vol.110 , pp. 16121-16126
    • Ghiaur, G.1    Yegnasubramanian, S.2    Perkins, B.3    Gucwa, J.L.4    Gerber, J.M.5    Jones, R.J.6
  • 41
    • 34250363611 scopus 로고    scopus 로고
    • Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment
    • Walkley C.R., Shea J.M., Sims N.A., Purton L.E., Orkin S.H. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 2007, 129:1081-1095.
    • (2007) Cell , vol.129 , pp. 1081-1095
    • Walkley, C.R.1    Shea, J.M.2    Sims, N.A.3    Purton, L.E.4    Orkin, S.H.5
  • 42
    • 79951694373 scopus 로고    scopus 로고
    • Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche
    • Chow A., Lucas D., Hidalgo A., et al. Bone marrow CD169+ macrophages promote the retention of hematopoietic stem and progenitor cells in the mesenchymal stem cell niche. J Exp Med 2011, 208:261-271.
    • (2011) J Exp Med , vol.208 , pp. 261-271
    • Chow, A.1    Lucas, D.2    Hidalgo, A.3
  • 43
    • 84874997081 scopus 로고    scopus 로고
    • CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
    • Greenbaum A., Hsu Y.M., Day R.B., et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 2013, 495:227-230.
    • (2013) Nature , vol.495 , pp. 227-230
    • Greenbaum, A.1    Hsu, Y.M.2    Day, R.B.3
  • 44
    • 84886416794 scopus 로고    scopus 로고
    • Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment
    • Mussai F., De Santo C., Abu-Dayyeh I., et al. Acute myeloid leukemia creates an arginase-dependent immunosuppressive microenvironment. Blood 2013, 122:749-758.
    • (2013) Blood , vol.122 , pp. 749-758
    • Mussai, F.1    De Santo, C.2    Abu-Dayyeh, I.3
  • 45
    • 67650632683 scopus 로고    scopus 로고
    • CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells
    • Majeti R., Chao M.P., Alizadeh A.A., et al. CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells. Cell 2009, 138:286-299.
    • (2009) Cell , vol.138 , pp. 286-299
    • Majeti, R.1    Chao, M.P.2    Alizadeh, A.A.3
  • 46
    • 84872311219 scopus 로고    scopus 로고
    • Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes
    • Lukasova E., Koristek Z., Klabusay M., et al. Granulocyte maturation determines ability to release chromatin NETs and loss of DNA damage response; these properties are absent in immature AML granulocytes. Biochim Biophys Acta 2013, 1833:767-779.
    • (2013) Biochim Biophys Acta , vol.1833 , pp. 767-779
    • Lukasova, E.1    Koristek, Z.2    Klabusay, M.3
  • 47
    • 41949111045 scopus 로고    scopus 로고
    • Acute promyelocytic leukemia: from highly fatal to highly curable
    • Wang Z.Y., Chen Z. Acute promyelocytic leukemia: from highly fatal to highly curable. Blood 2008, 111:2505-2515.
    • (2008) Blood , vol.111 , pp. 2505-2515
    • Wang, Z.Y.1    Chen, Z.2
  • 48
    • 84880287051 scopus 로고    scopus 로고
    • Retinoic acid and arsenic trioxide for acute promyelocytic leukemia
    • Lo-Coco F., Avvisati G., Vignetti M., et al. Retinoic acid and arsenic trioxide for acute promyelocytic leukemia. N Engl J Med 2013, 369:111-121.
    • (2013) N Engl J Med , vol.369 , pp. 111-121
    • Lo-Coco, F.1    Avvisati, G.2    Vignetti, M.3
  • 49
    • 58149240890 scopus 로고    scopus 로고
    • Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B
    • Schlenk R.F., Dohner K., Kneba M., et al. Gene mutations and response to treatment with all-trans retinoic acid in elderly patients with acute myeloid leukemia. Results from the AMLSG Trial AML HD98B. Haematologica 2009, 94:54-60.
    • (2009) Haematologica , vol.94 , pp. 54-60
    • Schlenk, R.F.1    Dohner, K.2    Kneba, M.3
  • 50
    • 84937499692 scopus 로고    scopus 로고
    • Bone marrow (BM) stromal expression of cytochrome P450 (CYP) enzymes protects acute myeloid leukemia (AML) from all-trans retinoic acid (atRA).
    • New Orleans, LA
    • Su M, Jones RJ, Ghiaur G. Bone marrow (BM) stromal expression of cytochrome P450 (CYP) enzymes protects acute myeloid leukemia (AML) from all-trans retinoic acid (atRA). Amercian Society of Hematology Annual Meeting 2013. New Orleans, LA; p 1449.
    • (2013) Amercian Society of Hematology Annual Meeting , pp. 1449
    • Su, M.1    Jones, R.J.2    Ghiaur, G.3
  • 51
    • 84937422965 scopus 로고    scopus 로고
    • The stem cell niche detoxifies chemotherapy and protects malignant hematopoietic cells via expression of cytochrome enzymes.
    • San Diego, CA
    • Alonso S, Su M, Jones RJ, Ghiaur G. The stem cell niche detoxifies chemotherapy and protects malignant hematopoietic cells via expression of cytochrome P450 enzymes. Amercian Association of Cancer Research Annual Meeting 2014. San Diego, CA; 2014.
    • (2014) Amercian Association of Cancer Research Annual Meeting 2014. , pp. 450
    • Alonso, S.1    Su, M.2    Jones, R.J.3    Ghiaur, G.4
  • 52
    • 84907225988 scopus 로고    scopus 로고
    • Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs
    • Boyd A.L., Campbell C.J., Hopkins C.I., et al. Niche displacement of human leukemic stem cells uniquely allows their competitive replacement with healthy HSPCs. J Exp Med 2014, 211:1925-1935.
    • (2014) J Exp Med , vol.211 , pp. 1925-1935
    • Boyd, A.L.1    Campbell, C.J.2    Hopkins, C.I.3
  • 53
    • 13744255245 scopus 로고    scopus 로고
    • CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice
    • Tavor S., Petit I., Porozov S., Avigdor A., Dar A., Leider-Trejo L., et al. CXCR4 regulates migration and development of human acute myelogenous leukemia stem cells in transplanted NOD/SCID mice. Cancer Res 2004, 64:2817-2824.
    • (2004) Cancer Res , vol.64 , pp. 2817-2824
    • Tavor, S.1    Petit, I.2    Porozov, S.3    Avigdor, A.4    Dar, A.5    Leider-Trejo, L.6
  • 54
    • 84860349448 scopus 로고    scopus 로고
    • A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia
    • Uy G.L., Rettig M.P., Motabi I.H., et al. A phase 1/2 study of chemosensitization with the CXCR4 antagonist plerixafor in relapsed or refractory acute myeloid leukemia. Blood 2012, 119:3917-3924.
    • (2012) Blood , vol.119 , pp. 3917-3924
    • Uy, G.L.1    Rettig, M.P.2    Motabi, I.H.3
  • 55
    • 3142620882 scopus 로고    scopus 로고
    • Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia
    • Rombouts E.J., Pavic B., Lowenberg B., Ploemacher R.E. Relation between CXCR-4 expression, Flt3 mutations, and unfavorable prognosis of adult acute myeloid leukemia. Blood 2004, 104:550-557.
    • (2004) Blood , vol.104 , pp. 550-557
    • Rombouts, E.J.1    Pavic, B.2    Lowenberg, B.3    Ploemacher, R.E.4
  • 56
    • 84967051165 scopus 로고    scopus 로고
    • BGB324, a selective small molecule Axl kinase inhibitor to overcome EMT-associated drug resistance in carcinomas: Therapeutic rationale and early clinical studies.
    • San Diego, CA
    • Wnuk-Lipinska K, Tiron C, Gausdal G, et al. BGB324, a selective small molecule Axl kinase inhibitor to overcome EMT-associated drug resistance in carcinomas: Therapeutic rationale and early clinical studies. Amercian Association for Cancer Research Annual Meeting 2014. San Diego, CA; 2014.
    • (2014) Amercian Association for Cancer Research Annual Meeting 2014.
    • Wnuk-Lipinska, K.1    Tiron, C.2    Gausdal, G.3
  • 57
    • 84937499693 scopus 로고    scopus 로고
    • Expression of Hedgehog pathway mediator Gli2 represents a clinically negative prognostic marker in acute myeloid leukemia and its inhibitor GANT61 exerts anti-leukemic effects in vitro.
    • New Orleans, LA
    • Wellbrock J, Koehler JM, Wagner K, et al. Expression of Hedgehog pathway mediator Gli2 represents a clinically negative prognostic marker in acute myeloid leukemia and its inhibitor GANT61 exerts anti-leukemic effects in vitro. Amercian Association of Cancer Research Annual Meeting 2013. New Orleans, LA; 2013.
    • (2013) Amercian Association of Cancer Research Annual Meeting.2013
    • Wellbrock, J.1    Koehler, J.M.2    Wagner, K.3
  • 58
    • 84885863582 scopus 로고    scopus 로고
    • Nonhematopoietic cells represent a more rational target of in vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitors
    • Boyd A.L., Salci K.R., Shapovalova Z., McIntyre B.A., Bhatia M. Nonhematopoietic cells represent a more rational target of in vivo hedgehog signaling affecting normal or acute myeloid leukemia progenitors. Exp Hematol 2013, 41:858-869.
    • (2013) Exp Hematol , vol.41 , pp. 858-869
    • Boyd, A.L.1    Salci, K.R.2    Shapovalova, Z.3    McIntyre, B.A.4    Bhatia, M.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.