Improving recruitment of older people to clinical trials: Use of the cohort multiple randomised controlled trial design

Age and Ageing

Volumn 44, Issue 4, 2015, Pages 547-550

  Clegg, Andrew ^a   Relton, Clare ^b   Young, John ^a   Witham, Miles ^c  

^a UNIVERSITY OF LEEDS   (United Kingdom)

^b UNIVERSITY OF SHEFFIELD   (United Kingdom)

^c UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Ageing; CmRCT; Dementia; Falls; Frailty; Older people

Indexed keywords

AGING; ARTICLE; COHORT ANALYSIS; FEASIBILITY STUDY; FOLLOW UP; HUMAN; INFORMED CONSENT; OBSERVATIONAL STUDY; OUTCOME ASSESSMENT; PATIENT PREFERENCE; PILOT STUDY; PRIORITY JOURNAL; QUALITATIVE RESEARCH; RANDOM SAMPLE; RANDOMIZED CONTROLLED TRIAL (TOPIC); AGE; AGED; ORGANIZATION AND MANAGEMENT; PATIENT SELECTION; PERSONNEL; PROCEDURES;

AGE FACTORS; AGED; AGING; HUMANS; PATIENT SELECTION; RANDOMIZED CONTROLLED TRIALS AS TOPIC; RESEARCH PERSONNEL;

EID: 84937404197     PISSN: 00020729     EISSN: 14682834     Source Type: Journal    
DOI: 10.1093/ageing/afv044     Document Type: Article

References (17)

1. McMurdo ME, Roberts H, Parker S, Wyatt N, May H, Goodman C, Jackson S, Gladman J, O'Mahony S, Ali K, Dickinson E, Edison P, Dyer C. Improving recruitment of older people to research through good practice. Age Ageing 2011; 40: 659-65.
2. Clegg A, Barber S, Young J, Iliffe S, Forster A. The Home-based Older People's Exercise (HOPE) trial: a pilot randomised controlled trial of a home-based exercise intervention for older people with frailty. Age Ageing 2014; 43: 687-95.
3. Azad N, Molnar F, Byszewski A. Lessons learned from a multidisciplinary heart failure clinic for older women: a randomised controlled trial. Age Ageing 2008; 37: 282-7.
4. Ross S, Grant A, Counsell C, Gillespie W, Russell I, Prescott R. Barriers to participation in randomised controlled trials: a systematic review. J Clin Epidemiol 1999; 52: 1143-56.
5. Holt R, Siddiqi N, Young J. The ethics of consent in delirium studies. J Psychosom Res 2008; 65: 283-7.
6. Relton C, Torgerson D, O'Cathain A, Nicholl J. Rethinking pragmatic randomised controlled trials: introducing the "cohort multiple randomised controlled trial" design. BMJ 2010; 340: c1066.
7. Hewitt C, Torgerson D, Miles J. Is there another way to take account of noncompliance in randomized controlled trials? CMAJ 2006; 175: 347.
8. Galea S, Tracy M. Participation rates in epidemiologic studies. Ann Epidemiol 2007; 17: 643-53.
9. Collerton J, Davies K, Jagger C, Kingston A, Bond J, Eccles MP, Robinson LA, Martin-Ruiz C, von Zglinicki T, James OF, Kirkwood TB. Health and disease in 85 year olds: baseline findings from the Newcastle 85+ cohort study. BMJ 2009; 339: b4904.
10. van Peet PG, Drewes YM, de Craen AJ, Westendorp RG, Gussekloo J, de Ruijter W. Prognostic value of cardiovascular disease status: the Leiden 85-plus study. Age (Dordr) 2012; 35: 1433-44.
11. Matthews FE, Arthur A, Barnes LE, Bond J, Jagger C, Robinson L, Brayne C. A two-decade comparison of prevalence of dementia in individuals aged 65 years and older from three geographical areas of England: results of the Cognitive Function and Ageing Study I and II. Lancet 2013; 382: 1405-12.
12. Ioannidis JP. Clinical trials: what a waste. BMJ. 2014; 349: g7089.
13. The Community Ageing Research (CARE) study. http://clahrc-yh.nihr.ac.uk/our-themes/primary-care-based-managementof-frailty-in-older-people/projects/the-yorkshire-humbercommunity-ageing-research-care-study (2 January 2015, date last accessed).
14. The Yorkshire Health Study. http://www.yorkshirehealthstudy.org/ (2 January 2015, date last accessed).
15. Viksveen P, Relton C. The effectiveness and cost-effectiveness of treatment by homeopaths in addition to usual care for depressed patients. ISRCTN 02484593. http://www.isrctn.com/ISRCTN02484593 (2 January 2015, date last accessed).
16. Cockayne S, Adamson J, Corbacho Martin B, Fairhurst C, Hewitt C, Hicks K, Hull R, Keenan AM, Lamb SE, Loughrey L, McIntosh C, Menz HB, Redmond AC, Rodgers S, Vernon W, Watson J, Torgerson D. The REFORM study protocol: a cohort randomised controlled trial of a multifaceted podiatry intervention for the prevention of falls in older people. BMJ Open 2014; 4: e006977.
17. Bower P. Comprehensive Longitudinal Assessment of Salford Integrated Care (CLASSIC): a study of the implementation and effectiveness of a new model of care for long-term conditions. ISRCTN 12286422. http://www.isrctn.com/ISRCTN12286422(2 January 2015, date last accessed).